APOPTOSIS OF BLOOD LYMPHOCYTES IN THE PATIENTS WITH AUTOIMMUNE THYROID DISORDERS

Abstract. This article presents results of apoptosis detection among blood lymphocytes from the patients with autoimmune thyroid disorders, i.e., autoimmune thyroiditis (AIT) at euthyroid and hypothyroid stages, and in diffuse toxic goiter (DTG). Contents of CD95+, annexin V presenting (apoptotic)...

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Autores principales:	O. I. Urazova, E. B. Kravets, V. V. Novitsky, A. V. Rogaleva, T. E. Budkina, O. A. Sinyukova, Yu. V. Nedossekova, V. N. Kuznetsova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	autoimmune thyroid disorders apoptosis annexin v cd95 tnfα Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/7cb48570722d44fb9ba241af6a3192da
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spelling	oai:doaj.org-article:7cb48570722d44fb9ba241af6a3192da2021-11-18T08:03:38ZAPOPTOSIS OF BLOOD LYMPHOCYTES IN THE PATIENTS WITH AUTOIMMUNE THYROID DISORDERS1563-06252313-741X10.15789/1563-0625-2008-2-3-187-192https://doaj.org/article/7cb48570722d44fb9ba241af6a3192da2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/132https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. This article presents results of apoptosis detection among blood lymphocytes from the patients with autoimmune thyroid disorders, i.e., autoimmune thyroiditis (AIT) at euthyroid and hypothyroid stages, and in diffuse toxic goiter (DTG). Contents of CD95+, annexin V presenting (apoptotic) cells and TNFα in blood were analyzed. It was shown, that altered regulation of programmed lymphocyte death in autoimmune thyroid disorders is demonstrated by increased content of TNFα and CD95+ lymphocytes, being accompanied by decreased numbers of apoptotic cells in blood. Meanwhile, this pathology is expressed mostly in DTG, while being less significant in AIT at euthyroid stage, than in thyroid hypofunction. Possible mechanisms of the revealed disturbances are discussed. (Med. Immunol., 2008, vol. 10, N 2-3, pp 187-192).O. I. UrazovaE. B. KravetsV. V. NovitskyA. V. RogalevaT. E. BudkinaO. A. SinyukovaYu. V. NedossekovaV. N. KuznetsovaSPb RAACIarticleautoimmune thyroid disordersapoptosisannexin vcd95tnfαImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 10, Iss 2-3, Pp 187-192 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	autoimmune thyroid disorders apoptosis annexin v cd95 tnfα Immunologic diseases. Allergy RC581-607
spellingShingle	autoimmune thyroid disorders apoptosis annexin v cd95 tnfα Immunologic diseases. Allergy RC581-607 O. I. Urazova E. B. Kravets V. V. Novitsky A. V. Rogaleva T. E. Budkina O. A. Sinyukova Yu. V. Nedossekova V. N. Kuznetsova APOPTOSIS OF BLOOD LYMPHOCYTES IN THE PATIENTS WITH AUTOIMMUNE THYROID DISORDERS
description	Abstract. This article presents results of apoptosis detection among blood lymphocytes from the patients with autoimmune thyroid disorders, i.e., autoimmune thyroiditis (AIT) at euthyroid and hypothyroid stages, and in diffuse toxic goiter (DTG). Contents of CD95+, annexin V presenting (apoptotic) cells and TNFα in blood were analyzed. It was shown, that altered regulation of programmed lymphocyte death in autoimmune thyroid disorders is demonstrated by increased content of TNFα and CD95+ lymphocytes, being accompanied by decreased numbers of apoptotic cells in blood. Meanwhile, this pathology is expressed mostly in DTG, while being less significant in AIT at euthyroid stage, than in thyroid hypofunction. Possible mechanisms of the revealed disturbances are discussed. (Med. Immunol., 2008, vol. 10, N 2-3, pp 187-192).
format	article
author	O. I. Urazova E. B. Kravets V. V. Novitsky A. V. Rogaleva T. E. Budkina O. A. Sinyukova Yu. V. Nedossekova V. N. Kuznetsova
author_facet	O. I. Urazova E. B. Kravets V. V. Novitsky A. V. Rogaleva T. E. Budkina O. A. Sinyukova Yu. V. Nedossekova V. N. Kuznetsova
author_sort	O. I. Urazova
title	APOPTOSIS OF BLOOD LYMPHOCYTES IN THE PATIENTS WITH AUTOIMMUNE THYROID DISORDERS
title_short	APOPTOSIS OF BLOOD LYMPHOCYTES IN THE PATIENTS WITH AUTOIMMUNE THYROID DISORDERS
title_full	APOPTOSIS OF BLOOD LYMPHOCYTES IN THE PATIENTS WITH AUTOIMMUNE THYROID DISORDERS
title_fullStr	APOPTOSIS OF BLOOD LYMPHOCYTES IN THE PATIENTS WITH AUTOIMMUNE THYROID DISORDERS
title_full_unstemmed	APOPTOSIS OF BLOOD LYMPHOCYTES IN THE PATIENTS WITH AUTOIMMUNE THYROID DISORDERS
title_sort	apoptosis of blood lymphocytes in the patients with autoimmune thyroid disorders
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/7cb48570722d44fb9ba241af6a3192da
work_keys_str_mv	AT oiurazova apoptosisofbloodlymphocytesinthepatientswithautoimmunethyroiddisorders AT ebkravets apoptosisofbloodlymphocytesinthepatientswithautoimmunethyroiddisorders AT vvnovitsky apoptosisofbloodlymphocytesinthepatientswithautoimmunethyroiddisorders AT avrogaleva apoptosisofbloodlymphocytesinthepatientswithautoimmunethyroiddisorders AT tebudkina apoptosisofbloodlymphocytesinthepatientswithautoimmunethyroiddisorders AT oasinyukova apoptosisofbloodlymphocytesinthepatientswithautoimmunethyroiddisorders AT yuvnedossekova apoptosisofbloodlymphocytesinthepatientswithautoimmunethyroiddisorders AT vnkuznetsova apoptosisofbloodlymphocytesinthepatientswithautoimmunethyroiddisorders
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APOPTOSIS OF BLOOD LYMPHOCYTES IN THE PATIENTS WITH AUTOIMMUNE THYROID DISORDERS

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