Acyl-chain saturation regulates the order of phosphatidylinositol 4,5-bisphosphate nanodomains

Acyl-chain saturation regulates the order of phosphatidylinositol 4,5-bisphosphate nanodomains

Phosphatidylinositol-4,5-bisphosphates are involved in membrane regulation and signalling in eukaryotes, with the distribution of acyl chains changing in response to stimuli. Here, molecular dynamics simulations and fluorescence spectroscopy experiments show that increasing acyl chain saturation inc...

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Autores principales: Luís Borges-Araújo, Marco M. Domingues, Alexander Fedorov, Nuno C. Santos, Manuel N. Melo, Fábio Fernandes
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Chemistry
QD1-999
Acceso en línea:https://doaj.org/article/7cb771ce4cc0462db82f85b499a4dd47
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spelling oai:doaj.org-article:7cb771ce4cc0462db82f85b499a4dd472021-12-05T12:05:04ZAcyl-chain saturation regulates the order of phosphatidylinositol 4,5-bisphosphate nanodomains10.1038/s42004-021-00603-12399-3669https://doaj.org/article/7cb771ce4cc0462db82f85b499a4dd472021-11-01T00:00:00Zhttps://doi.org/10.1038/s42004-021-00603-1https://doaj.org/toc/2399-3669Phosphatidylinositol-4,5-bisphosphates are involved in membrane regulation and signalling in eukaryotes, with the distribution of acyl chains changing in response to stimuli. Here, molecular dynamics simulations and fluorescence spectroscopy experiments show that increasing acyl chain saturation increases the ordering of lipid nanodomains in artificial membranes.Luís Borges-AraújoMarco M. DominguesAlexander FedorovNuno C. SantosManuel N. MeloFábio FernandesNature PortfolioarticleChemistryQD1-999ENCommunications Chemistry, Vol 4, Iss 1, Pp 1-13 (2021)
institution DOAJ
collection DOAJ
language EN
topic Chemistry
QD1-999
spellingShingle Chemistry
QD1-999
Luís Borges-Araújo
Marco M. Domingues
Alexander Fedorov
Nuno C. Santos
Manuel N. Melo
Fábio Fernandes
Acyl-chain saturation regulates the order of phosphatidylinositol 4,5-bisphosphate nanodomains
description Phosphatidylinositol-4,5-bisphosphates are involved in membrane regulation and signalling in eukaryotes, with the distribution of acyl chains changing in response to stimuli. Here, molecular dynamics simulations and fluorescence spectroscopy experiments show that increasing acyl chain saturation increases the ordering of lipid nanodomains in artificial membranes.
format article
author Luís Borges-Araújo
Marco M. Domingues
Alexander Fedorov
Nuno C. Santos
Manuel N. Melo
Fábio Fernandes
author_facet Luís Borges-Araújo
Marco M. Domingues
Alexander Fedorov
Nuno C. Santos
Manuel N. Melo
Fábio Fernandes
author_sort Luís Borges-Araújo
title Acyl-chain saturation regulates the order of phosphatidylinositol 4,5-bisphosphate nanodomains
title_short Acyl-chain saturation regulates the order of phosphatidylinositol 4,5-bisphosphate nanodomains
title_full Acyl-chain saturation regulates the order of phosphatidylinositol 4,5-bisphosphate nanodomains
title_fullStr Acyl-chain saturation regulates the order of phosphatidylinositol 4,5-bisphosphate nanodomains
title_full_unstemmed Acyl-chain saturation regulates the order of phosphatidylinositol 4,5-bisphosphate nanodomains
title_sort acyl-chain saturation regulates the order of phosphatidylinositol 4,5-bisphosphate nanodomains
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/7cb771ce4cc0462db82f85b499a4dd47
work_keys_str_mv AT luisborgesaraujo acylchainsaturationregulatestheorderofphosphatidylinositol45bisphosphatenanodomains
AT marcomdomingues acylchainsaturationregulatestheorderofphosphatidylinositol45bisphosphatenanodomains
AT alexanderfedorov acylchainsaturationregulatestheorderofphosphatidylinositol45bisphosphatenanodomains
AT nunocsantos acylchainsaturationregulatestheorderofphosphatidylinositol45bisphosphatenanodomains
AT manuelnmelo acylchainsaturationregulatestheorderofphosphatidylinositol45bisphosphatenanodomains
AT fabiofernandes acylchainsaturationregulatestheorderofphosphatidylinositol45bisphosphatenanodomains
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