Topical ferumoxytol nanoparticles disrupt biofilms and prevent tooth decay in vivo via intrinsic catalytic activity

Ferumoxytol is a nanoparticle formulation approved for systemic use to treat iron deficiency. Liu et al. show that topical use of ferumoxytol, in combination with low concentrations of H2O2, disrupts intractable oral biofilms and prevents tooth decay in vitro and in an animal model.

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Autores principales:	Yuan Liu, Pratap C. Naha, Geelsu Hwang, Dongyeop Kim, Yue Huang, Aurea Simon-Soro, Hoi-In Jung, Zhi Ren, Yong Li, Sarah Gubara, Faizan Alawi, Domenick Zero, Anderson T. Hara, David P. Cormode, Hyun Koo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7cc3c29b9ca3476e958adfda2a1090bd
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spelling	oai:doaj.org-article:7cc3c29b9ca3476e958adfda2a1090bd2021-12-02T16:49:54ZTopical ferumoxytol nanoparticles disrupt biofilms and prevent tooth decay in vivo via intrinsic catalytic activity10.1038/s41467-018-05342-x2041-1723https://doaj.org/article/7cc3c29b9ca3476e958adfda2a1090bd2018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05342-xhttps://doaj.org/toc/2041-1723Ferumoxytol is a nanoparticle formulation approved for systemic use to treat iron deficiency. Liu et al. show that topical use of ferumoxytol, in combination with low concentrations of H2O2, disrupts intractable oral biofilms and prevents tooth decay in vitro and in an animal model.Yuan LiuPratap C. NahaGeelsu HwangDongyeop KimYue HuangAurea Simon-SoroHoi-In JungZhi RenYong LiSarah GubaraFaizan AlawiDomenick ZeroAnderson T. HaraDavid P. CormodeHyun KooNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuan Liu Pratap C. Naha Geelsu Hwang Dongyeop Kim Yue Huang Aurea Simon-Soro Hoi-In Jung Zhi Ren Yong Li Sarah Gubara Faizan Alawi Domenick Zero Anderson T. Hara David P. Cormode Hyun Koo Topical ferumoxytol nanoparticles disrupt biofilms and prevent tooth decay in vivo via intrinsic catalytic activity
description	Ferumoxytol is a nanoparticle formulation approved for systemic use to treat iron deficiency. Liu et al. show that topical use of ferumoxytol, in combination with low concentrations of H2O2, disrupts intractable oral biofilms and prevents tooth decay in vitro and in an animal model.
format	article
author	Yuan Liu Pratap C. Naha Geelsu Hwang Dongyeop Kim Yue Huang Aurea Simon-Soro Hoi-In Jung Zhi Ren Yong Li Sarah Gubara Faizan Alawi Domenick Zero Anderson T. Hara David P. Cormode Hyun Koo
author_facet	Yuan Liu Pratap C. Naha Geelsu Hwang Dongyeop Kim Yue Huang Aurea Simon-Soro Hoi-In Jung Zhi Ren Yong Li Sarah Gubara Faizan Alawi Domenick Zero Anderson T. Hara David P. Cormode Hyun Koo
author_sort	Yuan Liu
title	Topical ferumoxytol nanoparticles disrupt biofilms and prevent tooth decay in vivo via intrinsic catalytic activity
title_short	Topical ferumoxytol nanoparticles disrupt biofilms and prevent tooth decay in vivo via intrinsic catalytic activity
title_full	Topical ferumoxytol nanoparticles disrupt biofilms and prevent tooth decay in vivo via intrinsic catalytic activity
title_fullStr	Topical ferumoxytol nanoparticles disrupt biofilms and prevent tooth decay in vivo via intrinsic catalytic activity
title_full_unstemmed	Topical ferumoxytol nanoparticles disrupt biofilms and prevent tooth decay in vivo via intrinsic catalytic activity
title_sort	topical ferumoxytol nanoparticles disrupt biofilms and prevent tooth decay in vivo via intrinsic catalytic activity
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/7cc3c29b9ca3476e958adfda2a1090bd
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Topical ferumoxytol nanoparticles disrupt biofilms and prevent tooth decay in vivo via intrinsic catalytic activity

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