Rules of engagement between αvβ6 integrin and foot-and-mouth disease virus

Foot-and-mouth disease virus binds αvβ6 integrin, via a conserved RGD motif in the flexible, exposed GH loop of capsid protein VP1, for cell entry. Here Kotechaet al.visualize this interaction with the VP1 GH loop extending away from the viral surface, engaging αvβ6 in an open, active state.

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Autores principales:	Abhay Kotecha, Quan Wang, Xianchi Dong, Serban L. Ilca, Marina Ondiviela, Rao Zihe, Julian Seago, Bryan Charleston, Elizabeth E. Fry, Nicola G. A. Abrescia, Timothy A. Springer, Juha T. Huiskonen, David I. Stuart
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7cc85a0a325f47d7981c002ee69ab865
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spelling	oai:doaj.org-article:7cc85a0a325f47d7981c002ee69ab8652021-12-02T15:38:46ZRules of engagement between αvβ6 integrin and foot-and-mouth disease virus10.1038/ncomms154082041-1723https://doaj.org/article/7cc85a0a325f47d7981c002ee69ab8652017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15408https://doaj.org/toc/2041-1723Foot-and-mouth disease virus binds αvβ6 integrin, via a conserved RGD motif in the flexible, exposed GH loop of capsid protein VP1, for cell entry. Here Kotechaet al.visualize this interaction with the VP1 GH loop extending away from the viral surface, engaging αvβ6 in an open, active state.Abhay KotechaQuan WangXianchi DongSerban L. IlcaMarina OndivielaRao ZiheJulian SeagoBryan CharlestonElizabeth E. FryNicola G. A. AbresciaTimothy A. SpringerJuha T. HuiskonenDavid I. StuartNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Abhay Kotecha Quan Wang Xianchi Dong Serban L. Ilca Marina Ondiviela Rao Zihe Julian Seago Bryan Charleston Elizabeth E. Fry Nicola G. A. Abrescia Timothy A. Springer Juha T. Huiskonen David I. Stuart Rules of engagement between αvβ6 integrin and foot-and-mouth disease virus
description	Foot-and-mouth disease virus binds αvβ6 integrin, via a conserved RGD motif in the flexible, exposed GH loop of capsid protein VP1, for cell entry. Here Kotechaet al.visualize this interaction with the VP1 GH loop extending away from the viral surface, engaging αvβ6 in an open, active state.
format	article
author	Abhay Kotecha Quan Wang Xianchi Dong Serban L. Ilca Marina Ondiviela Rao Zihe Julian Seago Bryan Charleston Elizabeth E. Fry Nicola G. A. Abrescia Timothy A. Springer Juha T. Huiskonen David I. Stuart
author_facet	Abhay Kotecha Quan Wang Xianchi Dong Serban L. Ilca Marina Ondiviela Rao Zihe Julian Seago Bryan Charleston Elizabeth E. Fry Nicola G. A. Abrescia Timothy A. Springer Juha T. Huiskonen David I. Stuart
author_sort	Abhay Kotecha
title	Rules of engagement between αvβ6 integrin and foot-and-mouth disease virus
title_short	Rules of engagement between αvβ6 integrin and foot-and-mouth disease virus
title_full	Rules of engagement between αvβ6 integrin and foot-and-mouth disease virus
title_fullStr	Rules of engagement between αvβ6 integrin and foot-and-mouth disease virus
title_full_unstemmed	Rules of engagement between αvβ6 integrin and foot-and-mouth disease virus
title_sort	rules of engagement between αvβ6 integrin and foot-and-mouth disease virus
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7cc85a0a325f47d7981c002ee69ab865
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Rules of engagement between αvβ6 integrin and foot-and-mouth disease virus

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