Oral anticoagulation to reduce risk of stroke in patients with atrial fibrillation: current and future therapies

Alpesh AminHospitalist Program, University of California, Irvine, Orange, CA, USAAbstract: Atrial fibrillation (AF) is associated with an increased incidence and severity of strokes. The burden of AF-related stroke is expected to increase in parallel with the aging of the population. Oral anticoagul...

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Autor principal:	Amin A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	atrial fibrillation stroke anticoagulation Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/7cc9046b4fcc4819bf96535b1218130a
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id	oai:doaj.org-article:7cc9046b4fcc4819bf96535b1218130a
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spelling	oai:doaj.org-article:7cc9046b4fcc4819bf96535b1218130a2021-12-02T01:08:50ZOral anticoagulation to reduce risk of stroke in patients with atrial fibrillation: current and future therapies1178-1998https://doaj.org/article/7cc9046b4fcc4819bf96535b1218130a2013-01-01T00:00:00Zhttps://www.dovepress.com/oral-anticoagulation-to-reduce-risk-of-stroke-in-patients-with-atrial--peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Alpesh AminHospitalist Program, University of California, Irvine, Orange, CA, USAAbstract: Atrial fibrillation (AF) is associated with an increased incidence and severity of strokes. The burden of AF-related stroke is expected to increase in parallel with the aging of the population. Oral anticoagulation with warfarin has been the pharmacologic standard for stroke risk reduction in patients with AF. When used with close attention to dosing and monitoring, warfarin is effective prophylactic therapy against thromboembolic stroke. However, it is underused by physicians, in part because of the known risks of adverse events with warfarin. Consequently, many patients with AF live with an avoidably elevated risk of stroke. New options, ie, oral anticoagulants with novel mechanisms of action, have recently been approved to reduce the risk of stroke in AF, and others are in development. These newer agents may address some of the complexities of warfarin use while providing similar or better efficacy and safety.Keywords: atrial fibrillation, stroke, oral anticoagulantsAmin ADove Medical Pressarticleatrial fibrillationstrokeanticoagulationGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 8, Pp 75-84 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	atrial fibrillation stroke anticoagulation Geriatrics RC952-954.6
spellingShingle	atrial fibrillation stroke anticoagulation Geriatrics RC952-954.6 Amin A Oral anticoagulation to reduce risk of stroke in patients with atrial fibrillation: current and future therapies
description	Alpesh AminHospitalist Program, University of California, Irvine, Orange, CA, USAAbstract: Atrial fibrillation (AF) is associated with an increased incidence and severity of strokes. The burden of AF-related stroke is expected to increase in parallel with the aging of the population. Oral anticoagulation with warfarin has been the pharmacologic standard for stroke risk reduction in patients with AF. When used with close attention to dosing and monitoring, warfarin is effective prophylactic therapy against thromboembolic stroke. However, it is underused by physicians, in part because of the known risks of adverse events with warfarin. Consequently, many patients with AF live with an avoidably elevated risk of stroke. New options, ie, oral anticoagulants with novel mechanisms of action, have recently been approved to reduce the risk of stroke in AF, and others are in development. These newer agents may address some of the complexities of warfarin use while providing similar or better efficacy and safety.Keywords: atrial fibrillation, stroke, oral anticoagulants
format	article
author	Amin A
author_facet	Amin A
author_sort	Amin A
title	Oral anticoagulation to reduce risk of stroke in patients with atrial fibrillation: current and future therapies
title_short	Oral anticoagulation to reduce risk of stroke in patients with atrial fibrillation: current and future therapies
title_full	Oral anticoagulation to reduce risk of stroke in patients with atrial fibrillation: current and future therapies
title_fullStr	Oral anticoagulation to reduce risk of stroke in patients with atrial fibrillation: current and future therapies
title_full_unstemmed	Oral anticoagulation to reduce risk of stroke in patients with atrial fibrillation: current and future therapies
title_sort	oral anticoagulation to reduce risk of stroke in patients with atrial fibrillation: current and future therapies
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/7cc9046b4fcc4819bf96535b1218130a
work_keys_str_mv	AT amina oralanticoagulationtoreduceriskofstrokeinpatientswithatrialfibrillationcurrentandfuturetherapies
_version_	1718403266034794496

Oral anticoagulation to reduce risk of stroke in patients with atrial fibrillation: current and future therapies

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