Innate lymphocyte-induced CXCR3B-mediated melanocyte apoptosis is a potential initiator of T-cell autoreactivity in vitiligo

Tissue signals that prime autoreactive T cells at the onset of autoimmunity remain enigmatic. Here the authors show NK and ILC1 cells are increased in vitiligo patients, and induce melanocyte apoptosis via CXCR3B, which in turn leads to increased priming of T cell responses in cell culture.

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Autores principales:	Meri K. Tulic, Elisa Cavazza, Yann Cheli, Arnaud Jacquel, Carmelo Luci, Nathalie Cardot-Leccia, Hanene Hadhiri-Bzioueche, Patricia Abbe, Maéva Gesson, Laura Sormani, Claire Regazzetti, Guillaume E. Beranger, Cedric Lereverend, Caroline Pons, Abdallah Khemis, Robert Ballotti, Corine Bertolotto, Stéphane Rocchi, Thierry Passeron
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7ccace62b4554630a57bcf27df328dfb
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spelling	oai:doaj.org-article:7ccace62b4554630a57bcf27df328dfb2021-12-02T16:51:02ZInnate lymphocyte-induced CXCR3B-mediated melanocyte apoptosis is a potential initiator of T-cell autoreactivity in vitiligo10.1038/s41467-019-09963-82041-1723https://doaj.org/article/7ccace62b4554630a57bcf27df328dfb2019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09963-8https://doaj.org/toc/2041-1723Tissue signals that prime autoreactive T cells at the onset of autoimmunity remain enigmatic. Here the authors show NK and ILC1 cells are increased in vitiligo patients, and induce melanocyte apoptosis via CXCR3B, which in turn leads to increased priming of T cell responses in cell culture.Meri K. TulicElisa CavazzaYann CheliArnaud JacquelCarmelo LuciNathalie Cardot-LecciaHanene Hadhiri-BziouechePatricia AbbeMaéva GessonLaura SormaniClaire RegazzettiGuillaume E. BerangerCedric LereverendCaroline PonsAbdallah KhemisRobert BallottiCorine BertolottoStéphane RocchiThierry PasseronNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Meri K. Tulic Elisa Cavazza Yann Cheli Arnaud Jacquel Carmelo Luci Nathalie Cardot-Leccia Hanene Hadhiri-Bzioueche Patricia Abbe Maéva Gesson Laura Sormani Claire Regazzetti Guillaume E. Beranger Cedric Lereverend Caroline Pons Abdallah Khemis Robert Ballotti Corine Bertolotto Stéphane Rocchi Thierry Passeron Innate lymphocyte-induced CXCR3B-mediated melanocyte apoptosis is a potential initiator of T-cell autoreactivity in vitiligo
description	Tissue signals that prime autoreactive T cells at the onset of autoimmunity remain enigmatic. Here the authors show NK and ILC1 cells are increased in vitiligo patients, and induce melanocyte apoptosis via CXCR3B, which in turn leads to increased priming of T cell responses in cell culture.
format	article
author	Meri K. Tulic Elisa Cavazza Yann Cheli Arnaud Jacquel Carmelo Luci Nathalie Cardot-Leccia Hanene Hadhiri-Bzioueche Patricia Abbe Maéva Gesson Laura Sormani Claire Regazzetti Guillaume E. Beranger Cedric Lereverend Caroline Pons Abdallah Khemis Robert Ballotti Corine Bertolotto Stéphane Rocchi Thierry Passeron
author_facet	Meri K. Tulic Elisa Cavazza Yann Cheli Arnaud Jacquel Carmelo Luci Nathalie Cardot-Leccia Hanene Hadhiri-Bzioueche Patricia Abbe Maéva Gesson Laura Sormani Claire Regazzetti Guillaume E. Beranger Cedric Lereverend Caroline Pons Abdallah Khemis Robert Ballotti Corine Bertolotto Stéphane Rocchi Thierry Passeron
author_sort	Meri K. Tulic
title	Innate lymphocyte-induced CXCR3B-mediated melanocyte apoptosis is a potential initiator of T-cell autoreactivity in vitiligo
title_short	Innate lymphocyte-induced CXCR3B-mediated melanocyte apoptosis is a potential initiator of T-cell autoreactivity in vitiligo
title_full	Innate lymphocyte-induced CXCR3B-mediated melanocyte apoptosis is a potential initiator of T-cell autoreactivity in vitiligo
title_fullStr	Innate lymphocyte-induced CXCR3B-mediated melanocyte apoptosis is a potential initiator of T-cell autoreactivity in vitiligo
title_full_unstemmed	Innate lymphocyte-induced CXCR3B-mediated melanocyte apoptosis is a potential initiator of T-cell autoreactivity in vitiligo
title_sort	innate lymphocyte-induced cxcr3b-mediated melanocyte apoptosis is a potential initiator of t-cell autoreactivity in vitiligo
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/7ccace62b4554630a57bcf27df328dfb
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Innate lymphocyte-induced CXCR3B-mediated melanocyte apoptosis is a potential initiator of T-cell autoreactivity in vitiligo

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