Innate lymphocyte-induced CXCR3B-mediated melanocyte apoptosis is a potential initiator of T-cell autoreactivity in vitiligo

Innate lymphocyte-induced CXCR3B-mediated melanocyte apoptosis is a potential initiator of T-cell autoreactivity in vitiligo

Tissue signals that prime autoreactive T cells at the onset of autoimmunity remain enigmatic. Here the authors show NK and ILC1 cells are increased in vitiligo patients, and induce melanocyte apoptosis via CXCR3B, which in turn leads to increased priming of T cell responses in cell culture.

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Auteurs principaux: Meri K. Tulic, Elisa Cavazza, Yann Cheli, Arnaud Jacquel, Carmelo Luci, Nathalie Cardot-Leccia, Hanene Hadhiri-Bzioueche, Patricia Abbe, Maéva Gesson, Laura Sormani, Claire Regazzetti, Guillaume E. Beranger, Cedric Lereverend, Caroline Pons, Abdallah Khemis, Robert Ballotti, Corine Bertolotto, Stéphane Rocchi, Thierry Passeron
Format: article
Langue:EN
Publié: Nature Portfolio 2019
Sujets:
Science
Q
Accès en ligne:https://doaj.org/article/7ccace62b4554630a57bcf27df328dfb
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