On the impact of vessel wall stiffness on quantitative flow dynamics in a synthetic model of the thoracic aorta

Abstract Aortic wall stiffening is a predictive marker for morbidity in hypertensive patients. Arterial pulse wave velocity (PWV) correlates with the level of stiffness and can be derived using non-invasive 4D-flow magnetic resonance imaging (MRI). The objectives of this study were twofold: to devel...

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Autores principales:	Judith Zimmermann, Michael Loecher, Fikunwa O. Kolawole, Kathrin Bäumler, Kyle Gifford, Seraina A. Dual, Marc Levenston, Alison L. Marsden, Daniel B. Ennis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7ccb6b00611c4ba493d76172f7c4e1aa
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spelling	oai:doaj.org-article:7ccb6b00611c4ba493d76172f7c4e1aa2021-12-02T11:45:01ZOn the impact of vessel wall stiffness on quantitative flow dynamics in a synthetic model of the thoracic aorta10.1038/s41598-021-86174-62045-2322https://doaj.org/article/7ccb6b00611c4ba493d76172f7c4e1aa2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86174-6https://doaj.org/toc/2045-2322Abstract Aortic wall stiffening is a predictive marker for morbidity in hypertensive patients. Arterial pulse wave velocity (PWV) correlates with the level of stiffness and can be derived using non-invasive 4D-flow magnetic resonance imaging (MRI). The objectives of this study were twofold: to develop subject-specific thoracic aorta models embedded into an MRI-compatible flow circuit operating under controlled physiological conditions; and to evaluate how a range of aortic wall stiffness impacts 4D-flow-based quantification of hemodynamics, particularly PWV. Three aorta models were 3D-printed using a novel photopolymer material at two compliant and one nearly rigid stiffnesses and characterized via tensile testing. Luminal pressure and 4D-flow MRI data were acquired for each model and cross-sectional net flow, peak velocities, and PWV were measured. In addition, the confounding effect of temporal resolution on all metrics was evaluated. Stiffer models resulted in increased systolic pressures (112, 116, and 133 mmHg), variations in velocity patterns, and increased peak velocities, peak flow rate, and PWV (5.8–7.3 m/s). Lower temporal resolution (20 ms down to 62.5 ms per image frame) impacted estimates of peak velocity and PWV (7.31 down to 4.77 m/s). Using compliant aorta models is essential to produce realistic flow dynamics and conditions that recapitulated in vivo hemodynamics.Judith ZimmermannMichael LoecherFikunwa O. KolawoleKathrin BäumlerKyle GiffordSeraina A. DualMarc LevenstonAlison L. MarsdenDaniel B. EnnisNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Judith Zimmermann Michael Loecher Fikunwa O. Kolawole Kathrin Bäumler Kyle Gifford Seraina A. Dual Marc Levenston Alison L. Marsden Daniel B. Ennis On the impact of vessel wall stiffness on quantitative flow dynamics in a synthetic model of the thoracic aorta
description	Abstract Aortic wall stiffening is a predictive marker for morbidity in hypertensive patients. Arterial pulse wave velocity (PWV) correlates with the level of stiffness and can be derived using non-invasive 4D-flow magnetic resonance imaging (MRI). The objectives of this study were twofold: to develop subject-specific thoracic aorta models embedded into an MRI-compatible flow circuit operating under controlled physiological conditions; and to evaluate how a range of aortic wall stiffness impacts 4D-flow-based quantification of hemodynamics, particularly PWV. Three aorta models were 3D-printed using a novel photopolymer material at two compliant and one nearly rigid stiffnesses and characterized via tensile testing. Luminal pressure and 4D-flow MRI data were acquired for each model and cross-sectional net flow, peak velocities, and PWV were measured. In addition, the confounding effect of temporal resolution on all metrics was evaluated. Stiffer models resulted in increased systolic pressures (112, 116, and 133 mmHg), variations in velocity patterns, and increased peak velocities, peak flow rate, and PWV (5.8–7.3 m/s). Lower temporal resolution (20 ms down to 62.5 ms per image frame) impacted estimates of peak velocity and PWV (7.31 down to 4.77 m/s). Using compliant aorta models is essential to produce realistic flow dynamics and conditions that recapitulated in vivo hemodynamics.
format	article
author	Judith Zimmermann Michael Loecher Fikunwa O. Kolawole Kathrin Bäumler Kyle Gifford Seraina A. Dual Marc Levenston Alison L. Marsden Daniel B. Ennis
author_facet	Judith Zimmermann Michael Loecher Fikunwa O. Kolawole Kathrin Bäumler Kyle Gifford Seraina A. Dual Marc Levenston Alison L. Marsden Daniel B. Ennis
author_sort	Judith Zimmermann
title	On the impact of vessel wall stiffness on quantitative flow dynamics in a synthetic model of the thoracic aorta
title_short	On the impact of vessel wall stiffness on quantitative flow dynamics in a synthetic model of the thoracic aorta
title_full	On the impact of vessel wall stiffness on quantitative flow dynamics in a synthetic model of the thoracic aorta
title_fullStr	On the impact of vessel wall stiffness on quantitative flow dynamics in a synthetic model of the thoracic aorta
title_full_unstemmed	On the impact of vessel wall stiffness on quantitative flow dynamics in a synthetic model of the thoracic aorta
title_sort	on the impact of vessel wall stiffness on quantitative flow dynamics in a synthetic model of the thoracic aorta
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7ccb6b00611c4ba493d76172f7c4e1aa
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On the impact of vessel wall stiffness on quantitative flow dynamics in a synthetic model of the thoracic aorta

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