Changes in the incidence and prevalence of type 1 and type 2 diabetes among 2 million children and adolescents in Hungary between 2001 and 2016 – a nationwide population-based study

Introduction The aim of the present study was to assess changes in the incidence and prevalence of type 1 diabetes (T1DM) and type 2 diabetes (T2DM) in children and adolescents in Hungary during the period 2001 to 2016 in order to provide nationwide population-based epidemiology data on diabetes in...

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Autores principales:	László Barkai, Zoltán Kiss, György Rokszin, Zsolt Abonyi-Tóth, György Jermendy, István Wittmann, Péter Kempler
Formato:	article
Lenguaje:	EN
Publicado:	Termedia Publishing House 2019
Materias:	children incidence prevalence adolescents type 2 diabetes type 1 diabetes Medicine R
Acceso en línea:	https://doaj.org/article/7ccf30c3a4c0420ead21f997a1c6e1a1
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spelling	oai:doaj.org-article:7ccf30c3a4c0420ead21f997a1c6e1a12021-12-02T16:59:25ZChanges in the incidence and prevalence of type 1 and type 2 diabetes among 2 million children and adolescents in Hungary between 2001 and 2016 – a nationwide population-based study1734-19221896-915110.5114/aoms.2019.88406https://doaj.org/article/7ccf30c3a4c0420ead21f997a1c6e1a12019-12-01T00:00:00Zhttps://www.archivesofmedicalscience.com/Changes-in-the-incidence-and-prevalence-of-type-1-and-type-2-diabetes-among-2-million,111760,0,2.htmlhttps://doaj.org/toc/1734-1922https://doaj.org/toc/1896-9151Introduction The aim of the present study was to assess changes in the incidence and prevalence of type 1 diabetes (T1DM) and type 2 diabetes (T2DM) in children and adolescents in Hungary during the period 2001 to 2016 in order to provide nationwide population-based epidemiology data on diabetes in youths aged 0–18 years. Material and methods This was a retrospective cohort study of Hungarian children and adolescents aged 18 years or younger. Pharmacologically treated diabetes cases were obtained through a population-based registry of the Hungarian National Health Insurance Fund. Time series analysis was used to evaluate the changing patterns of the incidence and prevalence for type 1 and type 2 diabetes covering a 16-year period. Results During the study period, 6,138 and 1,997 new T1DM and T2DM cases were observed, respectively. Newly diagnosed T2DM cases accounted for 24.5% of all incident diabetes cases. Incidence of T1DM increased from 16/100,000 to 23/100,000 (R2 = 0.7681; p < 0.0001). The male-to-female ratio among newly diagnosed T1DM patients did not change over the study period. Prevalence of T1DM rose from 114/100,000 to 209/100,000 (R2 = 0.9909; p < 0.0001). The prevalent T1DM cases showed significant male predominance in every year (p < 0.05). Incidence of T2DM decreased from 8/100,000 to 5/100,000 (R2 = 0.4977; p < 0.0014). The overall prevalence of T2DM did not change significantly. Prevalent T2DM cases showed significant female predominance in every year (p < 0.0001). A significant decrease in male-to female ratio was observed among newly diagnosed T2DM cases over the study period (p < 0.0001). Conclusions According to these population-based Hungarian data of children and adolescents with diabetes, T1DM is still the most common form and its frequency continues to rise, affecting more males than females. A high proportion of patients have T2DM, affecting more females than males, but the occurrence of medically treated cases is not increasing. The decrease in male-to-female ratio in newly diagnosed T2DM cases needs further investigations.László BarkaiZoltán KissGyörgy RokszinZsolt Abonyi-TóthGyörgy JermendyIstván WittmannPéter KemplerTermedia Publishing Housearticlechildrenincidenceprevalenceadolescentstype 2 diabetestype 1 diabetesMedicineRENArchives of Medical Science, Vol 16, Iss 1, Pp 34-41 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	children incidence prevalence adolescents type 2 diabetes type 1 diabetes Medicine R
spellingShingle	children incidence prevalence adolescents type 2 diabetes type 1 diabetes Medicine R László Barkai Zoltán Kiss György Rokszin Zsolt Abonyi-Tóth György Jermendy István Wittmann Péter Kempler Changes in the incidence and prevalence of type 1 and type 2 diabetes among 2 million children and adolescents in Hungary between 2001 and 2016 – a nationwide population-based study
description	Introduction The aim of the present study was to assess changes in the incidence and prevalence of type 1 diabetes (T1DM) and type 2 diabetes (T2DM) in children and adolescents in Hungary during the period 2001 to 2016 in order to provide nationwide population-based epidemiology data on diabetes in youths aged 0–18 years. Material and methods This was a retrospective cohort study of Hungarian children and adolescents aged 18 years or younger. Pharmacologically treated diabetes cases were obtained through a population-based registry of the Hungarian National Health Insurance Fund. Time series analysis was used to evaluate the changing patterns of the incidence and prevalence for type 1 and type 2 diabetes covering a 16-year period. Results During the study period, 6,138 and 1,997 new T1DM and T2DM cases were observed, respectively. Newly diagnosed T2DM cases accounted for 24.5% of all incident diabetes cases. Incidence of T1DM increased from 16/100,000 to 23/100,000 (R2 = 0.7681; p < 0.0001). The male-to-female ratio among newly diagnosed T1DM patients did not change over the study period. Prevalence of T1DM rose from 114/100,000 to 209/100,000 (R2 = 0.9909; p < 0.0001). The prevalent T1DM cases showed significant male predominance in every year (p < 0.05). Incidence of T2DM decreased from 8/100,000 to 5/100,000 (R2 = 0.4977; p < 0.0014). The overall prevalence of T2DM did not change significantly. Prevalent T2DM cases showed significant female predominance in every year (p < 0.0001). A significant decrease in male-to female ratio was observed among newly diagnosed T2DM cases over the study period (p < 0.0001). Conclusions According to these population-based Hungarian data of children and adolescents with diabetes, T1DM is still the most common form and its frequency continues to rise, affecting more males than females. A high proportion of patients have T2DM, affecting more females than males, but the occurrence of medically treated cases is not increasing. The decrease in male-to-female ratio in newly diagnosed T2DM cases needs further investigations.
format	article
author	László Barkai Zoltán Kiss György Rokszin Zsolt Abonyi-Tóth György Jermendy István Wittmann Péter Kempler
author_facet	László Barkai Zoltán Kiss György Rokszin Zsolt Abonyi-Tóth György Jermendy István Wittmann Péter Kempler
author_sort	László Barkai
title	Changes in the incidence and prevalence of type 1 and type 2 diabetes among 2 million children and adolescents in Hungary between 2001 and 2016 – a nationwide population-based study
title_short	Changes in the incidence and prevalence of type 1 and type 2 diabetes among 2 million children and adolescents in Hungary between 2001 and 2016 – a nationwide population-based study
title_full	Changes in the incidence and prevalence of type 1 and type 2 diabetes among 2 million children and adolescents in Hungary between 2001 and 2016 – a nationwide population-based study
title_fullStr	Changes in the incidence and prevalence of type 1 and type 2 diabetes among 2 million children and adolescents in Hungary between 2001 and 2016 – a nationwide population-based study
title_full_unstemmed	Changes in the incidence and prevalence of type 1 and type 2 diabetes among 2 million children and adolescents in Hungary between 2001 and 2016 – a nationwide population-based study
title_sort	changes in the incidence and prevalence of type 1 and type 2 diabetes among 2 million children and adolescents in hungary between 2001 and 2016 – a nationwide population-based study
publisher	Termedia Publishing House
publishDate	2019
url	https://doaj.org/article/7ccf30c3a4c0420ead21f997a1c6e1a1
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Changes in the incidence and prevalence of type 1 and type 2 diabetes among 2 million children and adolescents in Hungary between 2001 and 2016 – a nationwide population-based study

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