Effects of cerebral small vessel disease on the outcomes in cryptogenic stroke with active cancer

Abstract Cerebral small vessel diseases (cSVDs) affect the prognosis of various types of ischemic stroke. Therefore, we evaluated the association between cSVD and the prognosis of cryptogenic stroke patients with active cancer. We enrolled patients diagnosed with cryptogenic stroke and active cancer...

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Autores principales:	Ki-Woong Nam, Hyung-Min Kwon, Yong-Seok Lee, Jeong-Min Kim, Sang-Bae Ko
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7ccff066b6bc485282f59d70a5a18775
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spelling	oai:doaj.org-article:7ccff066b6bc485282f59d70a5a187752021-12-02T15:28:46ZEffects of cerebral small vessel disease on the outcomes in cryptogenic stroke with active cancer10.1038/s41598-021-97154-12045-2322https://doaj.org/article/7ccff066b6bc485282f59d70a5a187752021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97154-1https://doaj.org/toc/2045-2322Abstract Cerebral small vessel diseases (cSVDs) affect the prognosis of various types of ischemic stroke. Therefore, we evaluated the association between cSVD and the prognosis of cryptogenic stroke patients with active cancer. We enrolled patients diagnosed with cryptogenic stroke and active cancer from 2010 to 2016. Early neurological deterioration (END) was defined as a ≥ 2-point increase in the total NIHSS score or a ≥ 1-point increase in the motor NIHSS score within the first 72 h. We defined an unfavorable outcome as the modified Rankin Scale (mRS) score ≥ 3 points. We analyzed cSVD separately for each subtype including white matter hyperintensity (WMH), silent brain infarct (SBI), and cerebral microbleed (CMB). A total of 179 cryptogenic stroke patients with active cancer were evaluated. In the multivariable analysis, SBI was significantly associated with END (adjusted odds ratio = 3.97, 95% confidence interval: 1.53–10.33). This close relationship between SBI and END increased proportionally with an increase in SBI burden. However, WMH and CMB showed no significant association with END. None of the cSVD subtypes showed a statistically significant relationship with the 3-month unfavorable outcome. SBI was the only parameter closely associated with END in cryptogenic stroke patients with active cancer.Ki-Woong NamHyung-Min KwonYong-Seok LeeJeong-Min KimSang-Bae KoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ki-Woong Nam Hyung-Min Kwon Yong-Seok Lee Jeong-Min Kim Sang-Bae Ko Effects of cerebral small vessel disease on the outcomes in cryptogenic stroke with active cancer
description	Abstract Cerebral small vessel diseases (cSVDs) affect the prognosis of various types of ischemic stroke. Therefore, we evaluated the association between cSVD and the prognosis of cryptogenic stroke patients with active cancer. We enrolled patients diagnosed with cryptogenic stroke and active cancer from 2010 to 2016. Early neurological deterioration (END) was defined as a ≥ 2-point increase in the total NIHSS score or a ≥ 1-point increase in the motor NIHSS score within the first 72 h. We defined an unfavorable outcome as the modified Rankin Scale (mRS) score ≥ 3 points. We analyzed cSVD separately for each subtype including white matter hyperintensity (WMH), silent brain infarct (SBI), and cerebral microbleed (CMB). A total of 179 cryptogenic stroke patients with active cancer were evaluated. In the multivariable analysis, SBI was significantly associated with END (adjusted odds ratio = 3.97, 95% confidence interval: 1.53–10.33). This close relationship between SBI and END increased proportionally with an increase in SBI burden. However, WMH and CMB showed no significant association with END. None of the cSVD subtypes showed a statistically significant relationship with the 3-month unfavorable outcome. SBI was the only parameter closely associated with END in cryptogenic stroke patients with active cancer.
format	article
author	Ki-Woong Nam Hyung-Min Kwon Yong-Seok Lee Jeong-Min Kim Sang-Bae Ko
author_facet	Ki-Woong Nam Hyung-Min Kwon Yong-Seok Lee Jeong-Min Kim Sang-Bae Ko
author_sort	Ki-Woong Nam
title	Effects of cerebral small vessel disease on the outcomes in cryptogenic stroke with active cancer
title_short	Effects of cerebral small vessel disease on the outcomes in cryptogenic stroke with active cancer
title_full	Effects of cerebral small vessel disease on the outcomes in cryptogenic stroke with active cancer
title_fullStr	Effects of cerebral small vessel disease on the outcomes in cryptogenic stroke with active cancer
title_full_unstemmed	Effects of cerebral small vessel disease on the outcomes in cryptogenic stroke with active cancer
title_sort	effects of cerebral small vessel disease on the outcomes in cryptogenic stroke with active cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7ccff066b6bc485282f59d70a5a18775
work_keys_str_mv	AT kiwoongnam effectsofcerebralsmallvesseldiseaseontheoutcomesincryptogenicstrokewithactivecancer AT hyungminkwon effectsofcerebralsmallvesseldiseaseontheoutcomesincryptogenicstrokewithactivecancer AT yongseoklee effectsofcerebralsmallvesseldiseaseontheoutcomesincryptogenicstrokewithactivecancer AT jeongminkim effectsofcerebralsmallvesseldiseaseontheoutcomesincryptogenicstrokewithactivecancer AT sangbaeko effectsofcerebralsmallvesseldiseaseontheoutcomesincryptogenicstrokewithactivecancer
_version_	1718387212061507584

Effects of cerebral small vessel disease on the outcomes in cryptogenic stroke with active cancer

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