Effects of cerebral small vessel disease on the outcomes in cryptogenic stroke with active cancer
Abstract Cerebral small vessel diseases (cSVDs) affect the prognosis of various types of ischemic stroke. Therefore, we evaluated the association between cSVD and the prognosis of cryptogenic stroke patients with active cancer. We enrolled patients diagnosed with cryptogenic stroke and active cancer...
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2021
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oai:doaj.org-article:7ccff066b6bc485282f59d70a5a187752021-12-02T15:28:46ZEffects of cerebral small vessel disease on the outcomes in cryptogenic stroke with active cancer10.1038/s41598-021-97154-12045-2322https://doaj.org/article/7ccff066b6bc485282f59d70a5a187752021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97154-1https://doaj.org/toc/2045-2322Abstract Cerebral small vessel diseases (cSVDs) affect the prognosis of various types of ischemic stroke. Therefore, we evaluated the association between cSVD and the prognosis of cryptogenic stroke patients with active cancer. We enrolled patients diagnosed with cryptogenic stroke and active cancer from 2010 to 2016. Early neurological deterioration (END) was defined as a ≥ 2-point increase in the total NIHSS score or a ≥ 1-point increase in the motor NIHSS score within the first 72 h. We defined an unfavorable outcome as the modified Rankin Scale (mRS) score ≥ 3 points. We analyzed cSVD separately for each subtype including white matter hyperintensity (WMH), silent brain infarct (SBI), and cerebral microbleed (CMB). A total of 179 cryptogenic stroke patients with active cancer were evaluated. In the multivariable analysis, SBI was significantly associated with END (adjusted odds ratio = 3.97, 95% confidence interval: 1.53–10.33). This close relationship between SBI and END increased proportionally with an increase in SBI burden. However, WMH and CMB showed no significant association with END. None of the cSVD subtypes showed a statistically significant relationship with the 3-month unfavorable outcome. SBI was the only parameter closely associated with END in cryptogenic stroke patients with active cancer.Ki-Woong NamHyung-Min KwonYong-Seok LeeJeong-Min KimSang-Bae KoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021) |
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Medicine R Science Q Ki-Woong Nam Hyung-Min Kwon Yong-Seok Lee Jeong-Min Kim Sang-Bae Ko Effects of cerebral small vessel disease on the outcomes in cryptogenic stroke with active cancer |
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Abstract Cerebral small vessel diseases (cSVDs) affect the prognosis of various types of ischemic stroke. Therefore, we evaluated the association between cSVD and the prognosis of cryptogenic stroke patients with active cancer. We enrolled patients diagnosed with cryptogenic stroke and active cancer from 2010 to 2016. Early neurological deterioration (END) was defined as a ≥ 2-point increase in the total NIHSS score or a ≥ 1-point increase in the motor NIHSS score within the first 72 h. We defined an unfavorable outcome as the modified Rankin Scale (mRS) score ≥ 3 points. We analyzed cSVD separately for each subtype including white matter hyperintensity (WMH), silent brain infarct (SBI), and cerebral microbleed (CMB). A total of 179 cryptogenic stroke patients with active cancer were evaluated. In the multivariable analysis, SBI was significantly associated with END (adjusted odds ratio = 3.97, 95% confidence interval: 1.53–10.33). This close relationship between SBI and END increased proportionally with an increase in SBI burden. However, WMH and CMB showed no significant association with END. None of the cSVD subtypes showed a statistically significant relationship with the 3-month unfavorable outcome. SBI was the only parameter closely associated with END in cryptogenic stroke patients with active cancer. |
format |
article |
author |
Ki-Woong Nam Hyung-Min Kwon Yong-Seok Lee Jeong-Min Kim Sang-Bae Ko |
author_facet |
Ki-Woong Nam Hyung-Min Kwon Yong-Seok Lee Jeong-Min Kim Sang-Bae Ko |
author_sort |
Ki-Woong Nam |
title |
Effects of cerebral small vessel disease on the outcomes in cryptogenic stroke with active cancer |
title_short |
Effects of cerebral small vessel disease on the outcomes in cryptogenic stroke with active cancer |
title_full |
Effects of cerebral small vessel disease on the outcomes in cryptogenic stroke with active cancer |
title_fullStr |
Effects of cerebral small vessel disease on the outcomes in cryptogenic stroke with active cancer |
title_full_unstemmed |
Effects of cerebral small vessel disease on the outcomes in cryptogenic stroke with active cancer |
title_sort |
effects of cerebral small vessel disease on the outcomes in cryptogenic stroke with active cancer |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/7ccff066b6bc485282f59d70a5a18775 |
work_keys_str_mv |
AT kiwoongnam effectsofcerebralsmallvesseldiseaseontheoutcomesincryptogenicstrokewithactivecancer AT hyungminkwon effectsofcerebralsmallvesseldiseaseontheoutcomesincryptogenicstrokewithactivecancer AT yongseoklee effectsofcerebralsmallvesseldiseaseontheoutcomesincryptogenicstrokewithactivecancer AT jeongminkim effectsofcerebralsmallvesseldiseaseontheoutcomesincryptogenicstrokewithactivecancer AT sangbaeko effectsofcerebralsmallvesseldiseaseontheoutcomesincryptogenicstrokewithactivecancer |
_version_ |
1718387212061507584 |