HSP27 is a partner of JAK2-STAT5 and a potential therapeutic target in myelofibrosis

Myelofibrosis is a chronic degenerative disorder characterized by progressive bone marrow fibrosis. Here, the authors show that the chaperone HSP27 contributes to myelofibrosis via regulation of the JAK2/STAT5 pathway, and that antisense oligonucleotides targeting HSP27 are effective in two mouse mo...

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Autores principales:	Margaux Sevin, Lucia Kubovcakova, Nicolas Pernet, Sébastien Causse, Franck Vitte, Jean Luc Villeval, Catherine Lacout, Marine Cordonnier, Fernando Rodrigues-Lima, Gaétan Chanteloup, Matthieu Mosca, Marie-Lorraine Chrétien, Jean Noël Bastie, Sylvain Audia, Paul Sagot, Selim Ramla, Laurent Martin, Martin Gleave, Valérie Mezger, Radek Skoda, Isabelle Plo, Carmen Garrido, François Girodon, Aurélie de Thonel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7cd28d8985ce47f7a61f528b7a0f931b
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spelling	oai:doaj.org-article:7cd28d8985ce47f7a61f528b7a0f931b2021-12-02T17:33:02ZHSP27 is a partner of JAK2-STAT5 and a potential therapeutic target in myelofibrosis10.1038/s41467-018-03627-92041-1723https://doaj.org/article/7cd28d8985ce47f7a61f528b7a0f931b2018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03627-9https://doaj.org/toc/2041-1723Myelofibrosis is a chronic degenerative disorder characterized by progressive bone marrow fibrosis. Here, the authors show that the chaperone HSP27 contributes to myelofibrosis via regulation of the JAK2/STAT5 pathway, and that antisense oligonucleotides targeting HSP27 are effective in two mouse models of the diseaseMargaux SevinLucia KubovcakovaNicolas PernetSébastien CausseFranck VitteJean Luc VillevalCatherine LacoutMarine CordonnierFernando Rodrigues-LimaGaétan ChanteloupMatthieu MoscaMarie-Lorraine ChrétienJean Noël BastieSylvain AudiaPaul SagotSelim RamlaLaurent MartinMartin GleaveValérie MezgerRadek SkodaIsabelle PloCarmen GarridoFrançois GirodonAurélie de ThonelNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Margaux Sevin Lucia Kubovcakova Nicolas Pernet Sébastien Causse Franck Vitte Jean Luc Villeval Catherine Lacout Marine Cordonnier Fernando Rodrigues-Lima Gaétan Chanteloup Matthieu Mosca Marie-Lorraine Chrétien Jean Noël Bastie Sylvain Audia Paul Sagot Selim Ramla Laurent Martin Martin Gleave Valérie Mezger Radek Skoda Isabelle Plo Carmen Garrido François Girodon Aurélie de Thonel HSP27 is a partner of JAK2-STAT5 and a potential therapeutic target in myelofibrosis
description	Myelofibrosis is a chronic degenerative disorder characterized by progressive bone marrow fibrosis. Here, the authors show that the chaperone HSP27 contributes to myelofibrosis via regulation of the JAK2/STAT5 pathway, and that antisense oligonucleotides targeting HSP27 are effective in two mouse models of the disease
format	article
author	Margaux Sevin Lucia Kubovcakova Nicolas Pernet Sébastien Causse Franck Vitte Jean Luc Villeval Catherine Lacout Marine Cordonnier Fernando Rodrigues-Lima Gaétan Chanteloup Matthieu Mosca Marie-Lorraine Chrétien Jean Noël Bastie Sylvain Audia Paul Sagot Selim Ramla Laurent Martin Martin Gleave Valérie Mezger Radek Skoda Isabelle Plo Carmen Garrido François Girodon Aurélie de Thonel
author_facet	Margaux Sevin Lucia Kubovcakova Nicolas Pernet Sébastien Causse Franck Vitte Jean Luc Villeval Catherine Lacout Marine Cordonnier Fernando Rodrigues-Lima Gaétan Chanteloup Matthieu Mosca Marie-Lorraine Chrétien Jean Noël Bastie Sylvain Audia Paul Sagot Selim Ramla Laurent Martin Martin Gleave Valérie Mezger Radek Skoda Isabelle Plo Carmen Garrido François Girodon Aurélie de Thonel
author_sort	Margaux Sevin
title	HSP27 is a partner of JAK2-STAT5 and a potential therapeutic target in myelofibrosis
title_short	HSP27 is a partner of JAK2-STAT5 and a potential therapeutic target in myelofibrosis
title_full	HSP27 is a partner of JAK2-STAT5 and a potential therapeutic target in myelofibrosis
title_fullStr	HSP27 is a partner of JAK2-STAT5 and a potential therapeutic target in myelofibrosis
title_full_unstemmed	HSP27 is a partner of JAK2-STAT5 and a potential therapeutic target in myelofibrosis
title_sort	hsp27 is a partner of jak2-stat5 and a potential therapeutic target in myelofibrosis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/7cd28d8985ce47f7a61f528b7a0f931b
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HSP27 is a partner of JAK2-STAT5 and a potential therapeutic target in myelofibrosis

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