Early affective processing in patients with acute posttraumatic stress disorder: magnetoencephalographic correlates.

<h4>Background</h4>In chronic PTSD, a preattentive neural alarm system responds rapidly to emotional information, leading to increased prefrontal cortex (PFC) activation at early processing stages (<100 ms). Enhanced PFC responses are followed by a reduction in occipito-temporal activ...

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Autores principales:	Markus Burgmer, Maimu Alissa Rehbein, Marco Wrenger, Judith Kandil, Gereon Heuft, Christian Steinberg, Bettina Pfleiderer, Markus Junghöfer
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7cd515f08a1e430f9cd0795f3edf0445
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spelling	oai:doaj.org-article:7cd515f08a1e430f9cd0795f3edf04452021-11-18T08:59:11ZEarly affective processing in patients with acute posttraumatic stress disorder: magnetoencephalographic correlates.1932-620310.1371/journal.pone.0071289https://doaj.org/article/7cd515f08a1e430f9cd0795f3edf04452013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23977010/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>In chronic PTSD, a preattentive neural alarm system responds rapidly to emotional information, leading to increased prefrontal cortex (PFC) activation at early processing stages (<100 ms). Enhanced PFC responses are followed by a reduction in occipito-temporal activity during later processing stages. However, it remains unknown if this neuronal pattern is a result of a long lasting mental disorder or if it represents changes in brain function as direct consequences of severe trauma.<h4>Methodology</h4>The present study investigates early fear network activity in acutely traumatized patients with PTSD. It focuses on the question whether dysfunctions previously observed in chronic PTSD patients are already present shortly after trauma exposure. We recorded neuromagnetic activity towards emotional pictures in seven acutely traumatized PTSD patients between one and seven weeks after trauma exposure and compared brain responses to a balanced healthy control sample. Inverse modelling served for mapping sources of differential activation in the brain.<h4>Principal findings</h4>Compared to the control group, acutely traumatized PTSD patients showed an enhanced PFC response to high-arousing pictures between 60 to 80 ms. This rapid prefrontal hypervigilance towards arousing pictorial stimuli was sustained during 120-300 ms, where it was accompanied by a reduced affective modulation of occipito-temporal neural processing.<h4>Conclusions</h4>Our findings indicate that the hypervigilance-avoidance pattern seen in chronic PTSD is not necessarily a product of an endured mental disorder, but arises as an almost immediate result of severe traumatisation. Thus, traumatic experiences can influence emotion processing strongly, leading to long-lasting changes in trauma network activation and expediting a chronic manifestation of maladaptive cognitive and behavioral symptoms.Markus BurgmerMaimu Alissa RehbeinMarco WrengerJudith KandilGereon HeuftChristian SteinbergBettina PfleidererMarkus JunghöferPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 8, p e71289 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Markus Burgmer Maimu Alissa Rehbein Marco Wrenger Judith Kandil Gereon Heuft Christian Steinberg Bettina Pfleiderer Markus Junghöfer Early affective processing in patients with acute posttraumatic stress disorder: magnetoencephalographic correlates.
description	<h4>Background</h4>In chronic PTSD, a preattentive neural alarm system responds rapidly to emotional information, leading to increased prefrontal cortex (PFC) activation at early processing stages (<100 ms). Enhanced PFC responses are followed by a reduction in occipito-temporal activity during later processing stages. However, it remains unknown if this neuronal pattern is a result of a long lasting mental disorder or if it represents changes in brain function as direct consequences of severe trauma.<h4>Methodology</h4>The present study investigates early fear network activity in acutely traumatized patients with PTSD. It focuses on the question whether dysfunctions previously observed in chronic PTSD patients are already present shortly after trauma exposure. We recorded neuromagnetic activity towards emotional pictures in seven acutely traumatized PTSD patients between one and seven weeks after trauma exposure and compared brain responses to a balanced healthy control sample. Inverse modelling served for mapping sources of differential activation in the brain.<h4>Principal findings</h4>Compared to the control group, acutely traumatized PTSD patients showed an enhanced PFC response to high-arousing pictures between 60 to 80 ms. This rapid prefrontal hypervigilance towards arousing pictorial stimuli was sustained during 120-300 ms, where it was accompanied by a reduced affective modulation of occipito-temporal neural processing.<h4>Conclusions</h4>Our findings indicate that the hypervigilance-avoidance pattern seen in chronic PTSD is not necessarily a product of an endured mental disorder, but arises as an almost immediate result of severe traumatisation. Thus, traumatic experiences can influence emotion processing strongly, leading to long-lasting changes in trauma network activation and expediting a chronic manifestation of maladaptive cognitive and behavioral symptoms.
format	article
author	Markus Burgmer Maimu Alissa Rehbein Marco Wrenger Judith Kandil Gereon Heuft Christian Steinberg Bettina Pfleiderer Markus Junghöfer
author_facet	Markus Burgmer Maimu Alissa Rehbein Marco Wrenger Judith Kandil Gereon Heuft Christian Steinberg Bettina Pfleiderer Markus Junghöfer
author_sort	Markus Burgmer
title	Early affective processing in patients with acute posttraumatic stress disorder: magnetoencephalographic correlates.
title_short	Early affective processing in patients with acute posttraumatic stress disorder: magnetoencephalographic correlates.
title_full	Early affective processing in patients with acute posttraumatic stress disorder: magnetoencephalographic correlates.
title_fullStr	Early affective processing in patients with acute posttraumatic stress disorder: magnetoencephalographic correlates.
title_full_unstemmed	Early affective processing in patients with acute posttraumatic stress disorder: magnetoencephalographic correlates.
title_sort	early affective processing in patients with acute posttraumatic stress disorder: magnetoencephalographic correlates.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/7cd515f08a1e430f9cd0795f3edf0445
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Early affective processing in patients with acute posttraumatic stress disorder: magnetoencephalographic correlates.

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