Lowered insulin signalling ameliorates age-related sleep fragmentation in Drosophila.

Sleep fragmentation, particularly reduced and interrupted night sleep, impairs the quality of life of older people. Strikingly similar declines in sleep quality are seen during ageing in laboratory animals, including the fruit fly Drosophila. We investigated whether reduced activity of the nutrient-...

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Autores principales:	Athanasios Metaxakis, Luke S Tain, Sebastian Grönke, Oliver Hendrich, Yvonne Hinze, Ulrike Birras, Linda Partridge
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/7cd5b48fc88141e1bb9469141b4723e4
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spelling	oai:doaj.org-article:7cd5b48fc88141e1bb9469141b4723e42021-11-18T05:37:31ZLowered insulin signalling ameliorates age-related sleep fragmentation in Drosophila.1544-91731545-788510.1371/journal.pbio.1001824https://doaj.org/article/7cd5b48fc88141e1bb9469141b4723e42014-04-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24690889/pdf/?tool=EBIhttps://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885Sleep fragmentation, particularly reduced and interrupted night sleep, impairs the quality of life of older people. Strikingly similar declines in sleep quality are seen during ageing in laboratory animals, including the fruit fly Drosophila. We investigated whether reduced activity of the nutrient- and stress-sensing insulin/insulin-like growth factor (IIS)/TOR signalling network, which ameliorates ageing in diverse organisms, could rescue the sleep fragmentation of ageing Drosophila. Lowered IIS/TOR network activity improved sleep quality, with increased night sleep and day activity and reduced sleep fragmentation. Reduced TOR activity, even when started for the first time late in life, improved sleep quality. The effects of reduced IIS/TOR network activity on day and night phenotypes were mediated through distinct mechanisms: Day activity was induced by adipokinetic hormone, dFOXO, and enhanced octopaminergic signalling. In contrast, night sleep duration and consolidation were dependent on reduced S6K and dopaminergic signalling. Our findings highlight the importance of different IIS/TOR components as potential therapeutic targets for pharmacological treatment of age-related sleep fragmentation in humans.Athanasios MetaxakisLuke S TainSebastian GrönkeOliver HendrichYvonne HinzeUlrike BirrasLinda PartridgePublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 12, Iss 4, p e1001824 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Athanasios Metaxakis Luke S Tain Sebastian Grönke Oliver Hendrich Yvonne Hinze Ulrike Birras Linda Partridge Lowered insulin signalling ameliorates age-related sleep fragmentation in Drosophila.
description	Sleep fragmentation, particularly reduced and interrupted night sleep, impairs the quality of life of older people. Strikingly similar declines in sleep quality are seen during ageing in laboratory animals, including the fruit fly Drosophila. We investigated whether reduced activity of the nutrient- and stress-sensing insulin/insulin-like growth factor (IIS)/TOR signalling network, which ameliorates ageing in diverse organisms, could rescue the sleep fragmentation of ageing Drosophila. Lowered IIS/TOR network activity improved sleep quality, with increased night sleep and day activity and reduced sleep fragmentation. Reduced TOR activity, even when started for the first time late in life, improved sleep quality. The effects of reduced IIS/TOR network activity on day and night phenotypes were mediated through distinct mechanisms: Day activity was induced by adipokinetic hormone, dFOXO, and enhanced octopaminergic signalling. In contrast, night sleep duration and consolidation were dependent on reduced S6K and dopaminergic signalling. Our findings highlight the importance of different IIS/TOR components as potential therapeutic targets for pharmacological treatment of age-related sleep fragmentation in humans.
format	article
author	Athanasios Metaxakis Luke S Tain Sebastian Grönke Oliver Hendrich Yvonne Hinze Ulrike Birras Linda Partridge
author_facet	Athanasios Metaxakis Luke S Tain Sebastian Grönke Oliver Hendrich Yvonne Hinze Ulrike Birras Linda Partridge
author_sort	Athanasios Metaxakis
title	Lowered insulin signalling ameliorates age-related sleep fragmentation in Drosophila.
title_short	Lowered insulin signalling ameliorates age-related sleep fragmentation in Drosophila.
title_full	Lowered insulin signalling ameliorates age-related sleep fragmentation in Drosophila.
title_fullStr	Lowered insulin signalling ameliorates age-related sleep fragmentation in Drosophila.
title_full_unstemmed	Lowered insulin signalling ameliorates age-related sleep fragmentation in Drosophila.
title_sort	lowered insulin signalling ameliorates age-related sleep fragmentation in drosophila.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/7cd5b48fc88141e1bb9469141b4723e4
work_keys_str_mv	AT athanasiosmetaxakis loweredinsulinsignallingamelioratesagerelatedsleepfragmentationindrosophila AT lukestain loweredinsulinsignallingamelioratesagerelatedsleepfragmentationindrosophila AT sebastiangronke loweredinsulinsignallingamelioratesagerelatedsleepfragmentationindrosophila AT oliverhendrich loweredinsulinsignallingamelioratesagerelatedsleepfragmentationindrosophila AT yvonnehinze loweredinsulinsignallingamelioratesagerelatedsleepfragmentationindrosophila AT ulrikebirras loweredinsulinsignallingamelioratesagerelatedsleepfragmentationindrosophila AT lindapartridge loweredinsulinsignallingamelioratesagerelatedsleepfragmentationindrosophila
_version_	1718424858300252160

Lowered insulin signalling ameliorates age-related sleep fragmentation in Drosophila.

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