Impaired reach-to-grasp kinematics in parkinsonian patients relates to dopamine-dependent, subthalamic beta bursts

Abstract Excessive beta-band oscillations in the subthalamic nucleus are key neural features of Parkinson’s disease. Yet the distinctive contributions of beta low and high bands, their dependency on striatal dopamine, and their correlates with movement kinematics are unclear. Here, we show that the...

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Autores principales:	Matteo Vissani, Chiara Palmisano, Jens Volkmann, Gianni Pezzoli, Silvestro Micera, Ioannis U. Isaias, Alberto Mazzoni
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/7cdbebd38a5e41d29578bb5a2a0167c6
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spelling	oai:doaj.org-article:7cdbebd38a5e41d29578bb5a2a0167c62021-12-02T16:13:42ZImpaired reach-to-grasp kinematics in parkinsonian patients relates to dopamine-dependent, subthalamic beta bursts10.1038/s41531-021-00187-62373-8057https://doaj.org/article/7cdbebd38a5e41d29578bb5a2a0167c62021-06-01T00:00:00Zhttps://doi.org/10.1038/s41531-021-00187-6https://doaj.org/toc/2373-8057Abstract Excessive beta-band oscillations in the subthalamic nucleus are key neural features of Parkinson’s disease. Yet the distinctive contributions of beta low and high bands, their dependency on striatal dopamine, and their correlates with movement kinematics are unclear. Here, we show that the movement phases of the reach-to-grasp motor task are coded by the subthalamic bursting activity in a maximally-informative beta high range. A strong, three-fold correlation linked beta high range bursts, imbalanced inter-hemispheric striatal dopaminergic tone, and impaired inter-joint movement coordination. These results provide new insight into the neural correlates of motor control in parkinsonian patients, paving the way for more informative use of beta-band features for adaptive deep brain stimulation devices.Matteo VissaniChiara PalmisanoJens VolkmannGianni PezzoliSilvestro MiceraIoannis U. IsaiasAlberto MazzoniNature PortfolioarticleNeurology. Diseases of the nervous systemRC346-429ENnpj Parkinson's Disease, Vol 7, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurology. Diseases of the nervous system RC346-429 Matteo Vissani Chiara Palmisano Jens Volkmann Gianni Pezzoli Silvestro Micera Ioannis U. Isaias Alberto Mazzoni Impaired reach-to-grasp kinematics in parkinsonian patients relates to dopamine-dependent, subthalamic beta bursts
description	Abstract Excessive beta-band oscillations in the subthalamic nucleus are key neural features of Parkinson’s disease. Yet the distinctive contributions of beta low and high bands, their dependency on striatal dopamine, and their correlates with movement kinematics are unclear. Here, we show that the movement phases of the reach-to-grasp motor task are coded by the subthalamic bursting activity in a maximally-informative beta high range. A strong, three-fold correlation linked beta high range bursts, imbalanced inter-hemispheric striatal dopaminergic tone, and impaired inter-joint movement coordination. These results provide new insight into the neural correlates of motor control in parkinsonian patients, paving the way for more informative use of beta-band features for adaptive deep brain stimulation devices.
format	article
author	Matteo Vissani Chiara Palmisano Jens Volkmann Gianni Pezzoli Silvestro Micera Ioannis U. Isaias Alberto Mazzoni
author_facet	Matteo Vissani Chiara Palmisano Jens Volkmann Gianni Pezzoli Silvestro Micera Ioannis U. Isaias Alberto Mazzoni
author_sort	Matteo Vissani
title	Impaired reach-to-grasp kinematics in parkinsonian patients relates to dopamine-dependent, subthalamic beta bursts
title_short	Impaired reach-to-grasp kinematics in parkinsonian patients relates to dopamine-dependent, subthalamic beta bursts
title_full	Impaired reach-to-grasp kinematics in parkinsonian patients relates to dopamine-dependent, subthalamic beta bursts
title_fullStr	Impaired reach-to-grasp kinematics in parkinsonian patients relates to dopamine-dependent, subthalamic beta bursts
title_full_unstemmed	Impaired reach-to-grasp kinematics in parkinsonian patients relates to dopamine-dependent, subthalamic beta bursts
title_sort	impaired reach-to-grasp kinematics in parkinsonian patients relates to dopamine-dependent, subthalamic beta bursts
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7cdbebd38a5e41d29578bb5a2a0167c6
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Impaired reach-to-grasp kinematics in parkinsonian patients relates to dopamine-dependent, subthalamic beta bursts

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