Receptor-targeted engineered probiotics mitigate lethal Listeria infection

Here, the authors characterize the effects of Lactobacillus casei strains engineered to express pathogenic or non-pathogenic Listeria adhesion protein (LAP) in systemic colonization and protection against lethal Listeria monocytogenes infection in mice and show that these engineered strains can colo...

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Main Authors:	Rishi Drolia, Mary Anne Roshni Amalaradjou, Valerie Ryan, Shivendra Tenguria, Dongqi Liu, Xingjian Bai, Luping Xu, Atul K. Singh, Abigail D. Cox, Victor Bernal-Crespo, James A. Schaber, Bruce M. Applegate, Ramesh Vemulapalli, Arun K. Bhunia
Format:	article
Language:	EN
Published:	Nature Portfolio 2020
Subjects:	Science Q
Online Access:	https://doaj.org/article/7cdc0b3205d14b14b2a162dfddf4533a
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spelling	oai:doaj.org-article:7cdc0b3205d14b14b2a162dfddf4533a2021-12-02T14:16:05ZReceptor-targeted engineered probiotics mitigate lethal Listeria infection10.1038/s41467-020-20200-52041-1723https://doaj.org/article/7cdc0b3205d14b14b2a162dfddf4533a2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20200-5https://doaj.org/toc/2041-1723Here, the authors characterize the effects of Lactobacillus casei strains engineered to express pathogenic or non-pathogenic Listeria adhesion protein (LAP) in systemic colonization and protection against lethal Listeria monocytogenes infection in mice and show that these engineered strains can colonize the intestine and prevent dissemination of L. monocytogenes and protect against lethal infection while promoting immunomodulatory effects.Rishi DroliaMary Anne Roshni AmalaradjouValerie RyanShivendra TenguriaDongqi LiuXingjian BaiLuping XuAtul K. SinghAbigail D. CoxVictor Bernal-CrespoJames A. SchaberBruce M. ApplegateRamesh VemulapalliArun K. BhuniaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-23 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rishi Drolia Mary Anne Roshni Amalaradjou Valerie Ryan Shivendra Tenguria Dongqi Liu Xingjian Bai Luping Xu Atul K. Singh Abigail D. Cox Victor Bernal-Crespo James A. Schaber Bruce M. Applegate Ramesh Vemulapalli Arun K. Bhunia Receptor-targeted engineered probiotics mitigate lethal Listeria infection
description	Here, the authors characterize the effects of Lactobacillus casei strains engineered to express pathogenic or non-pathogenic Listeria adhesion protein (LAP) in systemic colonization and protection against lethal Listeria monocytogenes infection in mice and show that these engineered strains can colonize the intestine and prevent dissemination of L. monocytogenes and protect against lethal infection while promoting immunomodulatory effects.
format	article
author	Rishi Drolia Mary Anne Roshni Amalaradjou Valerie Ryan Shivendra Tenguria Dongqi Liu Xingjian Bai Luping Xu Atul K. Singh Abigail D. Cox Victor Bernal-Crespo James A. Schaber Bruce M. Applegate Ramesh Vemulapalli Arun K. Bhunia
author_facet	Rishi Drolia Mary Anne Roshni Amalaradjou Valerie Ryan Shivendra Tenguria Dongqi Liu Xingjian Bai Luping Xu Atul K. Singh Abigail D. Cox Victor Bernal-Crespo James A. Schaber Bruce M. Applegate Ramesh Vemulapalli Arun K. Bhunia
author_sort	Rishi Drolia
title	Receptor-targeted engineered probiotics mitigate lethal Listeria infection
title_short	Receptor-targeted engineered probiotics mitigate lethal Listeria infection
title_full	Receptor-targeted engineered probiotics mitigate lethal Listeria infection
title_fullStr	Receptor-targeted engineered probiotics mitigate lethal Listeria infection
title_full_unstemmed	Receptor-targeted engineered probiotics mitigate lethal Listeria infection
title_sort	receptor-targeted engineered probiotics mitigate lethal listeria infection
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/7cdc0b3205d14b14b2a162dfddf4533a
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Receptor-targeted engineered probiotics mitigate lethal Listeria infection

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