Enhanced Skin Performance of Emulgel vs. Cream as Systems for Topical Delivery of Herbal Actives (Immortelle Extract and Hemp Oil)

Immortelle, as rich source of chlorogenic acid and the phloroglucinol alpha-pyrone compound arzanol, possesses anti-inflammatory and antioxidant properties, affects cell regeneration, and has positive effect on many skin conditions. Hemp oil, characterized by a favorable omega-6 to omega-3 ratio, as...

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Autores principales:	Vanja M. Tadić, Ana Žugić, Milica Martinović, Milica Stanković, Svetolik Maksimović, Almut Frank, Ivana Nešić
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	immortelle hemp oil emulgel cream skin bioengineering Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/7cdc3a1d009d462aa11790e205bae427
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spelling	oai:doaj.org-article:7cdc3a1d009d462aa11790e205bae4272021-11-25T18:41:50ZEnhanced Skin Performance of Emulgel vs. Cream as Systems for Topical Delivery of Herbal Actives (Immortelle Extract and Hemp Oil)10.3390/pharmaceutics131119191999-4923https://doaj.org/article/7cdc3a1d009d462aa11790e205bae4272021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1919https://doaj.org/toc/1999-4923Immortelle, as rich source of chlorogenic acid and the phloroglucinol alpha-pyrone compound arzanol, possesses anti-inflammatory and antioxidant properties, affects cell regeneration, and has positive effect on many skin conditions. Hemp oil, characterized by a favorable omega-6 to omega-3 ratio, as well as an abundance of essential fatty acids and vitamin E, participates in immunoregulation and also act as an anti-inflammatory. In the present study, we examined the effect on the skin of creams and emulgels with immortelle extract and hemp oil, by comparing them to placebo samples and a non-treated control. A long-term in vivo study of biophysical skin characteristics, which lasted for 30 days, was conducted on 25 healthy human volunteers. Measured parameters were electrical capacitance of the <i>stratum corneum</i>, trans-epidermal water loss (TEWL), and skin pH and erythema index. Further, a sensory study was carried out in which the panelists had to choose descriptive terms for sensory attributes in questionnaire. The results showed that application of all preparations led to increase of skin hydration and TEWL reduction, while the skin was not irritated, and its normal pH was not disrupted. This study also showed importance of the carrier. Not only were emulgels described by panelists as preparations with better sensory properties, there was a significant difference between the skin hydration effect of emulgel with immortelle extract and hemp oil compared to the placebo emulgel, which was not the case with creams. Such findings indicated enhanced delivery of herbal active substances from emulgel compared to the cream.Vanja M. TadićAna ŽugićMilica MartinovićMilica StankovićSvetolik MaksimovićAlmut FrankIvana NešićMDPI AGarticleimmortellehemp oilemulgelcreamskin bioengineeringPharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1919, p 1919 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	immortelle hemp oil emulgel cream skin bioengineering Pharmacy and materia medica RS1-441
spellingShingle	immortelle hemp oil emulgel cream skin bioengineering Pharmacy and materia medica RS1-441 Vanja M. Tadić Ana Žugić Milica Martinović Milica Stanković Svetolik Maksimović Almut Frank Ivana Nešić Enhanced Skin Performance of Emulgel vs. Cream as Systems for Topical Delivery of Herbal Actives (Immortelle Extract and Hemp Oil)
description	Immortelle, as rich source of chlorogenic acid and the phloroglucinol alpha-pyrone compound arzanol, possesses anti-inflammatory and antioxidant properties, affects cell regeneration, and has positive effect on many skin conditions. Hemp oil, characterized by a favorable omega-6 to omega-3 ratio, as well as an abundance of essential fatty acids and vitamin E, participates in immunoregulation and also act as an anti-inflammatory. In the present study, we examined the effect on the skin of creams and emulgels with immortelle extract and hemp oil, by comparing them to placebo samples and a non-treated control. A long-term in vivo study of biophysical skin characteristics, which lasted for 30 days, was conducted on 25 healthy human volunteers. Measured parameters were electrical capacitance of the <i>stratum corneum</i>, trans-epidermal water loss (TEWL), and skin pH and erythema index. Further, a sensory study was carried out in which the panelists had to choose descriptive terms for sensory attributes in questionnaire. The results showed that application of all preparations led to increase of skin hydration and TEWL reduction, while the skin was not irritated, and its normal pH was not disrupted. This study also showed importance of the carrier. Not only were emulgels described by panelists as preparations with better sensory properties, there was a significant difference between the skin hydration effect of emulgel with immortelle extract and hemp oil compared to the placebo emulgel, which was not the case with creams. Such findings indicated enhanced delivery of herbal active substances from emulgel compared to the cream.
format	article
author	Vanja M. Tadić Ana Žugić Milica Martinović Milica Stanković Svetolik Maksimović Almut Frank Ivana Nešić
author_facet	Vanja M. Tadić Ana Žugić Milica Martinović Milica Stanković Svetolik Maksimović Almut Frank Ivana Nešić
author_sort	Vanja M. Tadić
title	Enhanced Skin Performance of Emulgel vs. Cream as Systems for Topical Delivery of Herbal Actives (Immortelle Extract and Hemp Oil)
title_short	Enhanced Skin Performance of Emulgel vs. Cream as Systems for Topical Delivery of Herbal Actives (Immortelle Extract and Hemp Oil)
title_full	Enhanced Skin Performance of Emulgel vs. Cream as Systems for Topical Delivery of Herbal Actives (Immortelle Extract and Hemp Oil)
title_fullStr	Enhanced Skin Performance of Emulgel vs. Cream as Systems for Topical Delivery of Herbal Actives (Immortelle Extract and Hemp Oil)
title_full_unstemmed	Enhanced Skin Performance of Emulgel vs. Cream as Systems for Topical Delivery of Herbal Actives (Immortelle Extract and Hemp Oil)
title_sort	enhanced skin performance of emulgel vs. cream as systems for topical delivery of herbal actives (immortelle extract and hemp oil)
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/7cdc3a1d009d462aa11790e205bae427
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Enhanced Skin Performance of Emulgel vs. Cream as Systems for Topical Delivery of Herbal Actives (Immortelle Extract and Hemp Oil)

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