Metabolic rate regulates L1 longevity in C. elegans.

Animals have to cope with starvation. The molecular mechanisms by which animals survive long-term starvation, however, are not clearly understood. When they hatch without food, C. elegans arrests development at the first larval stage (L1) and survives more than two weeks. Here we show that the survi...

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Autores principales:	Inhwan Lee, Amber Hendrix, Jeongho Kim, Jennifer Yoshimoto, Young-Jai You
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7cdced7cec7e4a6c836bed56e1160d63
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id	oai:doaj.org-article:7cdced7cec7e4a6c836bed56e1160d63
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spelling	oai:doaj.org-article:7cdced7cec7e4a6c836bed56e1160d632021-11-18T07:06:19ZMetabolic rate regulates L1 longevity in C. elegans.1932-620310.1371/journal.pone.0044720https://doaj.org/article/7cdced7cec7e4a6c836bed56e1160d632012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22970296/?tool=EBIhttps://doaj.org/toc/1932-6203Animals have to cope with starvation. The molecular mechanisms by which animals survive long-term starvation, however, are not clearly understood. When they hatch without food, C. elegans arrests development at the first larval stage (L1) and survives more than two weeks. Here we show that the survival span of arrested L1s, which we call L1 longevity, is a starvation response regulated by metabolic rate during starvation. A high rate of metabolism shortens the L1 survival span, whereas a low rate of metabolism lengthens it. The longer worms are starved, the slower they grow once they are fed, suggesting that L1 arrest has metabolic costs. Furthermore, mutants of genes that regulate metabolism show altered L1 longevity. Among them, we found that AMP-dependent protein kinase (AMPK), as a key energy sensor, regulates L1 longevity by regulating this metabolic arrest. Our results suggest that L1 longevity is determined by metabolic rate and that AMPK as a master regulator of metabolism controls this arrest so that the animals survive long-term starvation.Inhwan LeeAmber HendrixJeongho KimJennifer YoshimotoYoung-Jai YouPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 9, p e44720 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Inhwan Lee Amber Hendrix Jeongho Kim Jennifer Yoshimoto Young-Jai You Metabolic rate regulates L1 longevity in C. elegans.
description	Animals have to cope with starvation. The molecular mechanisms by which animals survive long-term starvation, however, are not clearly understood. When they hatch without food, C. elegans arrests development at the first larval stage (L1) and survives more than two weeks. Here we show that the survival span of arrested L1s, which we call L1 longevity, is a starvation response regulated by metabolic rate during starvation. A high rate of metabolism shortens the L1 survival span, whereas a low rate of metabolism lengthens it. The longer worms are starved, the slower they grow once they are fed, suggesting that L1 arrest has metabolic costs. Furthermore, mutants of genes that regulate metabolism show altered L1 longevity. Among them, we found that AMP-dependent protein kinase (AMPK), as a key energy sensor, regulates L1 longevity by regulating this metabolic arrest. Our results suggest that L1 longevity is determined by metabolic rate and that AMPK as a master regulator of metabolism controls this arrest so that the animals survive long-term starvation.
format	article
author	Inhwan Lee Amber Hendrix Jeongho Kim Jennifer Yoshimoto Young-Jai You
author_facet	Inhwan Lee Amber Hendrix Jeongho Kim Jennifer Yoshimoto Young-Jai You
author_sort	Inhwan Lee
title	Metabolic rate regulates L1 longevity in C. elegans.
title_short	Metabolic rate regulates L1 longevity in C. elegans.
title_full	Metabolic rate regulates L1 longevity in C. elegans.
title_fullStr	Metabolic rate regulates L1 longevity in C. elegans.
title_full_unstemmed	Metabolic rate regulates L1 longevity in C. elegans.
title_sort	metabolic rate regulates l1 longevity in c. elegans.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/7cdced7cec7e4a6c836bed56e1160d63
work_keys_str_mv	AT inhwanlee metabolicrateregulatesl1longevityincelegans AT amberhendrix metabolicrateregulatesl1longevityincelegans AT jeonghokim metabolicrateregulatesl1longevityincelegans AT jenniferyoshimoto metabolicrateregulatesl1longevityincelegans AT youngjaiyou metabolicrateregulatesl1longevityincelegans
_version_	1718423923362627584

Metabolic rate regulates L1 longevity in C. elegans.

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