Driving regeneration, instead of healing, in adult mammals: the decisive role of resident macrophages through efferocytosis

Abstract Tissue repair after lesion usually leads to scar healing and thus loss of function in adult mammals. In contrast, other adult vertebrates such as amphibians have the ability to regenerate and restore tissue homeostasis after lesion. Understanding the control of the repair outcome is thus a...

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Autores principales:	Lise Rabiller, Virginie Robert, Adèle Arlat, Elodie Labit, Marielle Ousset, Marie Salon, Agnès Coste, Léa Da Costa-Fernandes, Paul Monsarrat, Bruno Ségui, Mireille André, Christophe Guissard, Marie-Laure Renoud, Marine Silva, Gilles Mithieux, Isabelle Raymond-Letron, Luc Pénicaud, Anne Lorsignol, Louis Casteilla, Cécile Dromard Berthézène, Béatrice Cousin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/7ce0827820f24724903bce91e7add729
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spelling	oai:doaj.org-article:7ce0827820f24724903bce91e7add7292021-12-02T17:06:12ZDriving regeneration, instead of healing, in adult mammals: the decisive role of resident macrophages through efferocytosis10.1038/s41536-021-00151-12057-3995https://doaj.org/article/7ce0827820f24724903bce91e7add7292021-08-01T00:00:00Zhttps://doi.org/10.1038/s41536-021-00151-1https://doaj.org/toc/2057-3995Abstract Tissue repair after lesion usually leads to scar healing and thus loss of function in adult mammals. In contrast, other adult vertebrates such as amphibians have the ability to regenerate and restore tissue homeostasis after lesion. Understanding the control of the repair outcome is thus a concerning challenge for regenerative medicine. We recently developed a model of induced tissue regeneration in adult mice allowing the comparison of the early steps of regenerative and scar healing processes. By using studies of gain and loss of function, specific cell depletion approaches, and hematopoietic chimeras we demonstrate here that tissue regeneration in adult mammals depends on an early and transient peak of granulocyte producing reactive oxygen species and an efficient efferocytosis specifically by tissue-resident macrophages. These findings highlight key and early cellular pathways able to drive tissue repair towards regeneration in adult mammals.Lise RabillerVirginie RobertAdèle ArlatElodie LabitMarielle OussetMarie SalonAgnès CosteLéa Da Costa-FernandesPaul MonsarratBruno SéguiMireille AndréChristophe GuissardMarie-Laure RenoudMarine SilvaGilles MithieuxIsabelle Raymond-LetronLuc PénicaudAnne LorsignolLouis CasteillaCécile Dromard BerthézèneBéatrice CousinNature PortfolioarticleMedicineRENnpj Regenerative Medicine, Vol 6, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Lise Rabiller Virginie Robert Adèle Arlat Elodie Labit Marielle Ousset Marie Salon Agnès Coste Léa Da Costa-Fernandes Paul Monsarrat Bruno Ségui Mireille André Christophe Guissard Marie-Laure Renoud Marine Silva Gilles Mithieux Isabelle Raymond-Letron Luc Pénicaud Anne Lorsignol Louis Casteilla Cécile Dromard Berthézène Béatrice Cousin Driving regeneration, instead of healing, in adult mammals: the decisive role of resident macrophages through efferocytosis
description	Abstract Tissue repair after lesion usually leads to scar healing and thus loss of function in adult mammals. In contrast, other adult vertebrates such as amphibians have the ability to regenerate and restore tissue homeostasis after lesion. Understanding the control of the repair outcome is thus a concerning challenge for regenerative medicine. We recently developed a model of induced tissue regeneration in adult mice allowing the comparison of the early steps of regenerative and scar healing processes. By using studies of gain and loss of function, specific cell depletion approaches, and hematopoietic chimeras we demonstrate here that tissue regeneration in adult mammals depends on an early and transient peak of granulocyte producing reactive oxygen species and an efficient efferocytosis specifically by tissue-resident macrophages. These findings highlight key and early cellular pathways able to drive tissue repair towards regeneration in adult mammals.
format	article
author	Lise Rabiller Virginie Robert Adèle Arlat Elodie Labit Marielle Ousset Marie Salon Agnès Coste Léa Da Costa-Fernandes Paul Monsarrat Bruno Ségui Mireille André Christophe Guissard Marie-Laure Renoud Marine Silva Gilles Mithieux Isabelle Raymond-Letron Luc Pénicaud Anne Lorsignol Louis Casteilla Cécile Dromard Berthézène Béatrice Cousin
author_facet	Lise Rabiller Virginie Robert Adèle Arlat Elodie Labit Marielle Ousset Marie Salon Agnès Coste Léa Da Costa-Fernandes Paul Monsarrat Bruno Ségui Mireille André Christophe Guissard Marie-Laure Renoud Marine Silva Gilles Mithieux Isabelle Raymond-Letron Luc Pénicaud Anne Lorsignol Louis Casteilla Cécile Dromard Berthézène Béatrice Cousin
author_sort	Lise Rabiller
title	Driving regeneration, instead of healing, in adult mammals: the decisive role of resident macrophages through efferocytosis
title_short	Driving regeneration, instead of healing, in adult mammals: the decisive role of resident macrophages through efferocytosis
title_full	Driving regeneration, instead of healing, in adult mammals: the decisive role of resident macrophages through efferocytosis
title_fullStr	Driving regeneration, instead of healing, in adult mammals: the decisive role of resident macrophages through efferocytosis
title_full_unstemmed	Driving regeneration, instead of healing, in adult mammals: the decisive role of resident macrophages through efferocytosis
title_sort	driving regeneration, instead of healing, in adult mammals: the decisive role of resident macrophages through efferocytosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7ce0827820f24724903bce91e7add729
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Driving regeneration, instead of healing, in adult mammals: the decisive role of resident macrophages through efferocytosis

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