Simple spectrophotometric methods for the determination of amlodipine and atorvastatin in bulk and tablets

Abstract Background Simultaneous spectrophotometric determination of samples containing more than one analyte presents analytical challenge; the choice of an analytical procedure is strictly related to the extent of overlapping between the individual absorption peaks of these components; if the abso...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Imad Osman Abu Reid, Hind Mohamed Farid, Sara Osman Eltayeb
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	Multiwavelength regression Absorbance factor Atorvastatin Amlodipine Spectrophotometry Therapeutics. Pharmacology RM1-950 Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/7cea4c9713a444058f6f774223bc439c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7cea4c9713a444058f6f774223bc439c
record_format	dspace
spelling	oai:doaj.org-article:7cea4c9713a444058f6f774223bc439c2021-12-05T12:21:00ZSimple spectrophotometric methods for the determination of amlodipine and atorvastatin in bulk and tablets10.1186/s43094-021-00377-22314-7253https://doaj.org/article/7cea4c9713a444058f6f774223bc439c2021-12-01T00:00:00Zhttps://doi.org/10.1186/s43094-021-00377-2https://doaj.org/toc/2314-7253Abstract Background Simultaneous spectrophotometric determination of samples containing more than one analyte presents analytical challenge; the choice of an analytical procedure is strictly related to the extent of overlapping between the individual absorption peaks of these components; if the absorption peaks are satisfactorily resolved, the determination is not problematic, but if the individual component signals are partly or totally overlapped, then powerful techniques are needed. Combined amlodipine and atorvastatin are typical example where special techniques are needed to resolve bands overlapping. Results Application of multiwavelength regression and absorbance factor methods to the analysis of atorvastatin and amlodipine combination proved to be satisfactorily capable of accurate and precise determination of the two analytes. The two methods recoveries were very close to the expected analytes concentrations, and the precision of the methods was < 2% relative standard deviation. Statistical comparison indicated that there is no significant difference between the assay results obtained by the two method as the calculated t values 0.91 and 1.13 for amlodipine and atorvastatin, respectively, were less than the tabulated t value 2.23 at 95% confidence level. Conclusion The proposed methods are accurate, precise, simple and inexpensive. They can be applied successfully to the analysis of the two drugs in combined dosage form.Imad Osman Abu ReidHind Mohamed FaridSara Osman EltayebSpringerOpenarticleMultiwavelength regressionAbsorbance factorAtorvastatinAmlodipineSpectrophotometryTherapeutics. PharmacologyRM1-950Pharmacy and materia medicaRS1-441ENFuture Journal of Pharmaceutical Sciences, Vol 7, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Multiwavelength regression Absorbance factor Atorvastatin Amlodipine Spectrophotometry Therapeutics. Pharmacology RM1-950 Pharmacy and materia medica RS1-441
spellingShingle	Multiwavelength regression Absorbance factor Atorvastatin Amlodipine Spectrophotometry Therapeutics. Pharmacology RM1-950 Pharmacy and materia medica RS1-441 Imad Osman Abu Reid Hind Mohamed Farid Sara Osman Eltayeb Simple spectrophotometric methods for the determination of amlodipine and atorvastatin in bulk and tablets
description	Abstract Background Simultaneous spectrophotometric determination of samples containing more than one analyte presents analytical challenge; the choice of an analytical procedure is strictly related to the extent of overlapping between the individual absorption peaks of these components; if the absorption peaks are satisfactorily resolved, the determination is not problematic, but if the individual component signals are partly or totally overlapped, then powerful techniques are needed. Combined amlodipine and atorvastatin are typical example where special techniques are needed to resolve bands overlapping. Results Application of multiwavelength regression and absorbance factor methods to the analysis of atorvastatin and amlodipine combination proved to be satisfactorily capable of accurate and precise determination of the two analytes. The two methods recoveries were very close to the expected analytes concentrations, and the precision of the methods was < 2% relative standard deviation. Statistical comparison indicated that there is no significant difference between the assay results obtained by the two method as the calculated t values 0.91 and 1.13 for amlodipine and atorvastatin, respectively, were less than the tabulated t value 2.23 at 95% confidence level. Conclusion The proposed methods are accurate, precise, simple and inexpensive. They can be applied successfully to the analysis of the two drugs in combined dosage form.
format	article
author	Imad Osman Abu Reid Hind Mohamed Farid Sara Osman Eltayeb
author_facet	Imad Osman Abu Reid Hind Mohamed Farid Sara Osman Eltayeb
author_sort	Imad Osman Abu Reid
title	Simple spectrophotometric methods for the determination of amlodipine and atorvastatin in bulk and tablets
title_short	Simple spectrophotometric methods for the determination of amlodipine and atorvastatin in bulk and tablets
title_full	Simple spectrophotometric methods for the determination of amlodipine and atorvastatin in bulk and tablets
title_fullStr	Simple spectrophotometric methods for the determination of amlodipine and atorvastatin in bulk and tablets
title_full_unstemmed	Simple spectrophotometric methods for the determination of amlodipine and atorvastatin in bulk and tablets
title_sort	simple spectrophotometric methods for the determination of amlodipine and atorvastatin in bulk and tablets
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/7cea4c9713a444058f6f774223bc439c
work_keys_str_mv	AT imadosmanabureid simplespectrophotometricmethodsforthedeterminationofamlodipineandatorvastatininbulkandtablets AT hindmohamedfarid simplespectrophotometricmethodsforthedeterminationofamlodipineandatorvastatininbulkandtablets AT saraosmaneltayeb simplespectrophotometricmethodsforthedeterminationofamlodipineandatorvastatininbulkandtablets
_version_	1718372025877135360

Simple spectrophotometric methods for the determination of amlodipine and atorvastatin in bulk and tablets

Ejemplares similares