Antidepressant- and anxiolytic-like activities of Rosmarinus officinalis extract in rodent models: Involvement of oxytocinergic system

Background: Oxytocin (OXT), a neuropeptide involved in mammal reproductive and prosocial behaviors, has been reported to interact with various stressor-provoked neurobiological changes, including neuroendocrine, neurotransmitter, and inflammatory processes. In view of disturbances in psychosocial re...

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Autores principales:	Kazunori Sasaki, Farhana Ferdousi, Satoshi Fukumitsu, Hidetoshi Kuwata, Hiroko Isoda
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Rosemary Oxytocinergic system Depression Anxiety Global gene expression COVID-19 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/7ceac5029b0e4c70b38df73a92ad1d82
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spelling	oai:doaj.org-article:7ceac5029b0e4c70b38df73a92ad1d822021-11-14T04:29:18ZAntidepressant- and anxiolytic-like activities of Rosmarinus officinalis extract in rodent models: Involvement of oxytocinergic system0753-332210.1016/j.biopha.2021.112291https://doaj.org/article/7ceac5029b0e4c70b38df73a92ad1d822021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0753332221010751https://doaj.org/toc/0753-3322Background: Oxytocin (OXT), a neuropeptide involved in mammal reproductive and prosocial behaviors, has been reported to interact with various stressor-provoked neurobiological changes, including neuroendocrine, neurotransmitter, and inflammatory processes. In view of disturbances in psychosocial relationships due to social isolation and physical distancing measures amid the COVID-19 pandemic, being one of the triggering factors for the recent rise in depression and anxiety, OXT is a potential candidate for a new antidepressant. Methods: In this present study, we have aimed to investigate the effects of oral administration of Rosmarinus officinalis extract (RE), extracted from distillation residue of rosemary essential oil, on central OXT level in the context of other stress biomarkers and neurotransmitter levels in mice models. Tail suspension test (TST) and elevated plus maze test (EPMT) following LPS injection were employed to assess depressive- and anxiety-like behavior in mice, respectively. Findings: Pretreatment with RE for seven days significantly improved behavior in TST and EPMT. Whole-genome microarray analysis reveals that RE significantly reversed TST stress-induced alterations in gene expressions related to oxytocinergic and neurotransmitter pathways and inflammatory processes. In both models, RE significantly increased central Oxt and Oxtr expressions, as well as OXT protein levels. RE also significantly attenuated stress-induced changes in serum corticosterone, brain and serum BDNF levels, and brain neurotransmitters levels in both models. Interpretation: Altogether, our study is the first to report antidepressant- and anxiolytic-like activities of RE through modulating oxytocinergic system in mice brain and thus highlights the prospects of RE in the treatment of depressive disorders of psychosocial nature.Kazunori SasakiFarhana FerdousiSatoshi FukumitsuHidetoshi KuwataHiroko IsodaElsevierarticleRosemaryOxytocinergic systemDepressionAnxietyGlobal gene expressionCOVID-19Therapeutics. PharmacologyRM1-950ENBiomedicine & Pharmacotherapy, Vol 144, Iss , Pp 112291- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Rosemary Oxytocinergic system Depression Anxiety Global gene expression COVID-19 Therapeutics. Pharmacology RM1-950
spellingShingle	Rosemary Oxytocinergic system Depression Anxiety Global gene expression COVID-19 Therapeutics. Pharmacology RM1-950 Kazunori Sasaki Farhana Ferdousi Satoshi Fukumitsu Hidetoshi Kuwata Hiroko Isoda Antidepressant- and anxiolytic-like activities of Rosmarinus officinalis extract in rodent models: Involvement of oxytocinergic system
description	Background: Oxytocin (OXT), a neuropeptide involved in mammal reproductive and prosocial behaviors, has been reported to interact with various stressor-provoked neurobiological changes, including neuroendocrine, neurotransmitter, and inflammatory processes. In view of disturbances in psychosocial relationships due to social isolation and physical distancing measures amid the COVID-19 pandemic, being one of the triggering factors for the recent rise in depression and anxiety, OXT is a potential candidate for a new antidepressant. Methods: In this present study, we have aimed to investigate the effects of oral administration of Rosmarinus officinalis extract (RE), extracted from distillation residue of rosemary essential oil, on central OXT level in the context of other stress biomarkers and neurotransmitter levels in mice models. Tail suspension test (TST) and elevated plus maze test (EPMT) following LPS injection were employed to assess depressive- and anxiety-like behavior in mice, respectively. Findings: Pretreatment with RE for seven days significantly improved behavior in TST and EPMT. Whole-genome microarray analysis reveals that RE significantly reversed TST stress-induced alterations in gene expressions related to oxytocinergic and neurotransmitter pathways and inflammatory processes. In both models, RE significantly increased central Oxt and Oxtr expressions, as well as OXT protein levels. RE also significantly attenuated stress-induced changes in serum corticosterone, brain and serum BDNF levels, and brain neurotransmitters levels in both models. Interpretation: Altogether, our study is the first to report antidepressant- and anxiolytic-like activities of RE through modulating oxytocinergic system in mice brain and thus highlights the prospects of RE in the treatment of depressive disorders of psychosocial nature.
format	article
author	Kazunori Sasaki Farhana Ferdousi Satoshi Fukumitsu Hidetoshi Kuwata Hiroko Isoda
author_facet	Kazunori Sasaki Farhana Ferdousi Satoshi Fukumitsu Hidetoshi Kuwata Hiroko Isoda
author_sort	Kazunori Sasaki
title	Antidepressant- and anxiolytic-like activities of Rosmarinus officinalis extract in rodent models: Involvement of oxytocinergic system
title_short	Antidepressant- and anxiolytic-like activities of Rosmarinus officinalis extract in rodent models: Involvement of oxytocinergic system
title_full	Antidepressant- and anxiolytic-like activities of Rosmarinus officinalis extract in rodent models: Involvement of oxytocinergic system
title_fullStr	Antidepressant- and anxiolytic-like activities of Rosmarinus officinalis extract in rodent models: Involvement of oxytocinergic system
title_full_unstemmed	Antidepressant- and anxiolytic-like activities of Rosmarinus officinalis extract in rodent models: Involvement of oxytocinergic system
title_sort	antidepressant- and anxiolytic-like activities of rosmarinus officinalis extract in rodent models: involvement of oxytocinergic system
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/7ceac5029b0e4c70b38df73a92ad1d82
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Antidepressant- and anxiolytic-like activities of Rosmarinus officinalis extract in rodent models: Involvement of oxytocinergic system

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