Lung toxicities of core–shell nanoparticles composed of carbon, cobalt, and silica
Mohammed T Al Samri,1,* Rafael Silva,2,* Saeeda Almarzooqi,3 Alia Albawardi,3 Aws Rashad Diab Othman,1 Ruqayya SMS Al Hanjeri,1 Shaikha KM Al Dawaar,1 Saeed Tariq,4 Abdul-Kader Souid,1 Tewodros Asefa2,51Department of Pediatrics, United Arab Emirates University, Abu Dhabi, United Arab Emirates; 2Depa...
Guardado en:
| Autores principales: | , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Dove Medical Press
2013
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/7cecab0c43144e74800bb0accfec0edb |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:7cecab0c43144e74800bb0accfec0edb |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:7cecab0c43144e74800bb0accfec0edb2021-12-02T02:16:44ZLung toxicities of core–shell nanoparticles composed of carbon, cobalt, and silica1176-91141178-2013https://doaj.org/article/7cecab0c43144e74800bb0accfec0edb2013-03-01T00:00:00Zhttp://www.dovepress.com/lung-toxicities-of-corendashshell-nanoparticles-composed-of-carbon-cob-a12536https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Mohammed T Al Samri,1,* Rafael Silva,2,* Saeeda Almarzooqi,3 Alia Albawardi,3 Aws Rashad Diab Othman,1 Ruqayya SMS Al Hanjeri,1 Shaikha KM Al Dawaar,1 Saeed Tariq,4 Abdul-Kader Souid,1 Tewodros Asefa2,51Department of Pediatrics, United Arab Emirates University, Abu Dhabi, United Arab Emirates; 2Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ, USA; 3Department of Pathology, 4Department of Anatomy, United Arab Emirates University, Abu Dhabi, United Arab Emirates; 5Department of Chemical Engineering and Biochemical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ, USA*These authors contributed equally to this workAbstract: We present here comparative assessments of murine lung toxicity (biocompatibility) after in vitro and in vivo exposures to carbon (C–SiO2-etched), carbon–silica (C–SiO2), carbon–cobalt–silica (C–Co–SiO2), and carbon–cobalt oxide–silica (C–Co3O4–SiO2) nanoparticles. These nanoparticles have potential applications in clinical medicine and bioimaging, and thus their possible adverse events require thorough investigation. The primary aim of this work was to explore whether the nanoparticles are biocompatible with pneumatocyte bioenergetics (cellular respiration and adenosine triphosphate content). Other objectives included assessments of caspase activity, lung structure, and cellular organelles. Pneumatocyte bioenergetics of murine lung remained preserved after treatment with C–SiO2-etched or C–SiO2 nanoparticles. C–SiO2-etched nanoparticles, however, increased caspase activity and altered lung structure more than C–SiO2 did. Consistent with the known mitochondrial toxicity of cobalt, both C–Co–SiO2 and C–Co3O4–SiO2 impaired lung tissue bioenergetics. C–Co–SiO2, however, increased caspase activity and altered lung structure more than C–Co3O4–SiO2. The results indicate that silica shell is essential for biocompatibility. Furthermore, cobalt oxide is the preferred phase over the zerovalent Co(0) phase to impart biocompatibility to cobalt-based nanoparticles.Keywords: carbon nanoparticles, cobalt nanoparticles, silica nanoparticles, cobalt oxide nanoparticles, biocompatibility, nanotoxicologyAl Samri MTSilva RAlmarzooqi SAlbawardi AOthman ARAl Hanjeri RSAl Dawaar SKTariq SSouid AKAsefa TDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2013, Iss default, Pp 1223-1244 (2013) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine (General) R5-920 |
| spellingShingle |
Medicine (General) R5-920 Al Samri MT Silva R Almarzooqi S Albawardi A Othman AR Al Hanjeri RS Al Dawaar SK Tariq S Souid AK Asefa T Lung toxicities of core–shell nanoparticles composed of carbon, cobalt, and silica |
| description |
Mohammed T Al Samri,1,* Rafael Silva,2,* Saeeda Almarzooqi,3 Alia Albawardi,3 Aws Rashad Diab Othman,1 Ruqayya SMS Al Hanjeri,1 Shaikha KM Al Dawaar,1 Saeed Tariq,4 Abdul-Kader Souid,1 Tewodros Asefa2,51Department of Pediatrics, United Arab Emirates University, Abu Dhabi, United Arab Emirates; 2Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ, USA; 3Department of Pathology, 4Department of Anatomy, United Arab Emirates University, Abu Dhabi, United Arab Emirates; 5Department of Chemical Engineering and Biochemical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ, USA*These authors contributed equally to this workAbstract: We present here comparative assessments of murine lung toxicity (biocompatibility) after in vitro and in vivo exposures to carbon (C–SiO2-etched), carbon–silica (C–SiO2), carbon–cobalt–silica (C–Co–SiO2), and carbon–cobalt oxide–silica (C–Co3O4–SiO2) nanoparticles. These nanoparticles have potential applications in clinical medicine and bioimaging, and thus their possible adverse events require thorough investigation. The primary aim of this work was to explore whether the nanoparticles are biocompatible with pneumatocyte bioenergetics (cellular respiration and adenosine triphosphate content). Other objectives included assessments of caspase activity, lung structure, and cellular organelles. Pneumatocyte bioenergetics of murine lung remained preserved after treatment with C–SiO2-etched or C–SiO2 nanoparticles. C–SiO2-etched nanoparticles, however, increased caspase activity and altered lung structure more than C–SiO2 did. Consistent with the known mitochondrial toxicity of cobalt, both C–Co–SiO2 and C–Co3O4–SiO2 impaired lung tissue bioenergetics. C–Co–SiO2, however, increased caspase activity and altered lung structure more than C–Co3O4–SiO2. The results indicate that silica shell is essential for biocompatibility. Furthermore, cobalt oxide is the preferred phase over the zerovalent Co(0) phase to impart biocompatibility to cobalt-based nanoparticles.Keywords: carbon nanoparticles, cobalt nanoparticles, silica nanoparticles, cobalt oxide nanoparticles, biocompatibility, nanotoxicology |
| format |
article |
| author |
Al Samri MT Silva R Almarzooqi S Albawardi A Othman AR Al Hanjeri RS Al Dawaar SK Tariq S Souid AK Asefa T |
| author_facet |
Al Samri MT Silva R Almarzooqi S Albawardi A Othman AR Al Hanjeri RS Al Dawaar SK Tariq S Souid AK Asefa T |
| author_sort |
Al Samri MT |
| title |
Lung toxicities of core–shell nanoparticles composed of carbon, cobalt, and silica |
| title_short |
Lung toxicities of core–shell nanoparticles composed of carbon, cobalt, and silica |
| title_full |
Lung toxicities of core–shell nanoparticles composed of carbon, cobalt, and silica |
| title_fullStr |
Lung toxicities of core–shell nanoparticles composed of carbon, cobalt, and silica |
| title_full_unstemmed |
Lung toxicities of core–shell nanoparticles composed of carbon, cobalt, and silica |
| title_sort |
lung toxicities of core–shell nanoparticles composed of carbon, cobalt, and silica |
| publisher |
Dove Medical Press |
| publishDate |
2013 |
| url |
https://doaj.org/article/7cecab0c43144e74800bb0accfec0edb |
| work_keys_str_mv |
AT alsamrimt lungtoxicitiesofcoreampndashshellnanoparticlescomposedofcarboncobaltandsilica AT silvar lungtoxicitiesofcoreampndashshellnanoparticlescomposedofcarboncobaltandsilica AT almarzooqis lungtoxicitiesofcoreampndashshellnanoparticlescomposedofcarboncobaltandsilica AT albawardia lungtoxicitiesofcoreampndashshellnanoparticlescomposedofcarboncobaltandsilica AT othmanar lungtoxicitiesofcoreampndashshellnanoparticlescomposedofcarboncobaltandsilica AT alhanjerirs lungtoxicitiesofcoreampndashshellnanoparticlescomposedofcarboncobaltandsilica AT aldawaarsk lungtoxicitiesofcoreampndashshellnanoparticlescomposedofcarboncobaltandsilica AT tariqs lungtoxicitiesofcoreampndashshellnanoparticlescomposedofcarboncobaltandsilica AT souidak lungtoxicitiesofcoreampndashshellnanoparticlescomposedofcarboncobaltandsilica AT asefat lungtoxicitiesofcoreampndashshellnanoparticlescomposedofcarboncobaltandsilica |
| _version_ |
1718402604765020160 |