Association of maternal pre-pregnancy low or increased body mass index with adverse pregnancy outcomes

Abstract This study investigated the association between pre-pregnancy body mass index (BMI) and adverse pregnancy outcomes among women participated in the National Free Preconception Health Examination Project in Guangdong Province, China, and explored these associations according to maternal age....

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Autores principales:	Jie Tang, Xinhong Zhu, Yanbing Chen, Dongming Huang, Henning Tiemeier, Ruoling Chen, Wei Bao, Qingguo Zhao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7cf21418b2d447b6a5403c7906a69233
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spelling	oai:doaj.org-article:7cf21418b2d447b6a5403c7906a692332021-12-02T10:54:30ZAssociation of maternal pre-pregnancy low or increased body mass index with adverse pregnancy outcomes10.1038/s41598-021-82064-z2045-2322https://doaj.org/article/7cf21418b2d447b6a5403c7906a692332021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82064-zhttps://doaj.org/toc/2045-2322Abstract This study investigated the association between pre-pregnancy body mass index (BMI) and adverse pregnancy outcomes among women participated in the National Free Preconception Health Examination Project in Guangdong Province, China, and explored these associations according to maternal age. Pre-pregnancy BMI was classified into underweight (BMI < 18.5 kg/m2), healthy weight (18.5–23.9 kg/m2), overweight (24.0–27.9 kg/m2), and obesity (≥ 28.0 kg/m2) according to Chinese criteria. Outcomes were preterm birth (PTB, delivery before 37 weeks of gestation), large for gestational age (LGA, birthweight above the 90th percentile for gestational age by infants’ sex), small for gestational age (SGA, birthweight below the 10th percentile for gestational age by infants’ sex), primary caesarean delivery, shoulder dystocia or birth injury, and stillbirth. Adjusted incidence risk ratios (aIRR) were calculated for underweight, overweight and obesity, respectively. Compared with healthy weight, underweight was associated with increased risk of PTB (aIRR 1.06, 95%CI 1.04–1.09) and SGA (1.23, 1.22–1.26) but inversely associated with LGA (0.83, 0.82–0.85), primary caesarean delivery (0.88, 0.87–0.90) and stillbirth (0.73, 0.53–0.99). Overweight was associated with increased risk of LGA (1.17, 1.14–1.19), primary caesarean delivery (1.18, 1.16–1.20) and stillbirth (1.44, 1.03–2.06), but inversely associated with SGA (0.92, 0.90–0.95) and shoulder dystocia or birth injury (0.86, 0.79–0.93). Obesity was associated with increased risk of PTB (1.12, 1.05–1.20), LGA (1.32, 1.27–1.37), primary caesarean delivery (1.45, 1.40–1.50), but inversely associated with SGA (0.92, 0.87–0.97). The aIRRs for underweight, overweight and obesity in relation to these adverse pregnancy outcomes ranged from 0.65 to 1.52 according to maternal age. In Chinese population, maternal pre-pregnancy BMI was significantly associated with the risk of adverse pregnancy outcomes and the risk differs according to maternal age. Further investigation is warranted to determine whether and how counselling and interventions for women with low or increased BMI before pregnancy can reduce the risk of adverse pregnancy outcomes.Jie TangXinhong ZhuYanbing ChenDongming HuangHenning TiemeierRuoling ChenWei BaoQingguo ZhaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jie Tang Xinhong Zhu Yanbing Chen Dongming Huang Henning Tiemeier Ruoling Chen Wei Bao Qingguo Zhao Association of maternal pre-pregnancy low or increased body mass index with adverse pregnancy outcomes
description	Abstract This study investigated the association between pre-pregnancy body mass index (BMI) and adverse pregnancy outcomes among women participated in the National Free Preconception Health Examination Project in Guangdong Province, China, and explored these associations according to maternal age. Pre-pregnancy BMI was classified into underweight (BMI < 18.5 kg/m2), healthy weight (18.5–23.9 kg/m2), overweight (24.0–27.9 kg/m2), and obesity (≥ 28.0 kg/m2) according to Chinese criteria. Outcomes were preterm birth (PTB, delivery before 37 weeks of gestation), large for gestational age (LGA, birthweight above the 90th percentile for gestational age by infants’ sex), small for gestational age (SGA, birthweight below the 10th percentile for gestational age by infants’ sex), primary caesarean delivery, shoulder dystocia or birth injury, and stillbirth. Adjusted incidence risk ratios (aIRR) were calculated for underweight, overweight and obesity, respectively. Compared with healthy weight, underweight was associated with increased risk of PTB (aIRR 1.06, 95%CI 1.04–1.09) and SGA (1.23, 1.22–1.26) but inversely associated with LGA (0.83, 0.82–0.85), primary caesarean delivery (0.88, 0.87–0.90) and stillbirth (0.73, 0.53–0.99). Overweight was associated with increased risk of LGA (1.17, 1.14–1.19), primary caesarean delivery (1.18, 1.16–1.20) and stillbirth (1.44, 1.03–2.06), but inversely associated with SGA (0.92, 0.90–0.95) and shoulder dystocia or birth injury (0.86, 0.79–0.93). Obesity was associated with increased risk of PTB (1.12, 1.05–1.20), LGA (1.32, 1.27–1.37), primary caesarean delivery (1.45, 1.40–1.50), but inversely associated with SGA (0.92, 0.87–0.97). The aIRRs for underweight, overweight and obesity in relation to these adverse pregnancy outcomes ranged from 0.65 to 1.52 according to maternal age. In Chinese population, maternal pre-pregnancy BMI was significantly associated with the risk of adverse pregnancy outcomes and the risk differs according to maternal age. Further investigation is warranted to determine whether and how counselling and interventions for women with low or increased BMI before pregnancy can reduce the risk of adverse pregnancy outcomes.
format	article
author	Jie Tang Xinhong Zhu Yanbing Chen Dongming Huang Henning Tiemeier Ruoling Chen Wei Bao Qingguo Zhao
author_facet	Jie Tang Xinhong Zhu Yanbing Chen Dongming Huang Henning Tiemeier Ruoling Chen Wei Bao Qingguo Zhao
author_sort	Jie Tang
title	Association of maternal pre-pregnancy low or increased body mass index with adverse pregnancy outcomes
title_short	Association of maternal pre-pregnancy low or increased body mass index with adverse pregnancy outcomes
title_full	Association of maternal pre-pregnancy low or increased body mass index with adverse pregnancy outcomes
title_fullStr	Association of maternal pre-pregnancy low or increased body mass index with adverse pregnancy outcomes
title_full_unstemmed	Association of maternal pre-pregnancy low or increased body mass index with adverse pregnancy outcomes
title_sort	association of maternal pre-pregnancy low or increased body mass index with adverse pregnancy outcomes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7cf21418b2d447b6a5403c7906a69233
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Association of maternal pre-pregnancy low or increased body mass index with adverse pregnancy outcomes

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