Dry Eye Treatment with Topical Cyclosporine 0.1% in Chondroitin Sulfate Ophthalmic Emulsion

Cynthia Matossian,1 William Trattler,2 Jennifer Loh3 1Matossian Eye Associates, Pennington, NJ, USA; 2Center for Excellence in Eye Care, Miami, FL, USA; 3Loh Ophthalmology Associates, Miami, FL, USACorrespondence: Cynthia MatossianMatossian Eye Associates, 2 Capital Way, Ste 326, Pennington, NJ, 085...

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Autores principales:	Matossian C, Trattler W, Loh J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	dry eye treatment dry eye disease cyclosporine 0.1% klarity-c immunosuppressive agent ded Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/7cf29abbb2cd433e95fbb7a304bc8c4e
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spelling	oai:doaj.org-article:7cf29abbb2cd433e95fbb7a304bc8c4e2021-12-02T17:02:14ZDry Eye Treatment with Topical Cyclosporine 0.1% in Chondroitin Sulfate Ophthalmic Emulsion1177-5483https://doaj.org/article/7cf29abbb2cd433e95fbb7a304bc8c4e2021-05-01T00:00:00Zhttps://www.dovepress.com/dry-eye-treatment-with-topical-cyclosporine-01-in-chondroitin-sulfate--peer-reviewed-fulltext-article-OPTHhttps://doaj.org/toc/1177-5483Cynthia Matossian,1 William Trattler,2 Jennifer Loh3 1Matossian Eye Associates, Pennington, NJ, USA; 2Center for Excellence in Eye Care, Miami, FL, USA; 3Loh Ophthalmology Associates, Miami, FL, USACorrespondence: Cynthia MatossianMatossian Eye Associates, 2 Capital Way, Ste 326, Pennington, NJ, 08534, USATel +1 215-230-9200Email cmatossian@cmassociatesllc.netPurpose: To evaluate the efficacy of topical cyclosporine 0.1% in chondroitin sulfate emulsion for the treatment of dry eye.Methods: This retrospective multicenter study included 100 eyes of 50 dry eye patients aged ≥ 18 years, with preoperative ocular surface disease index (OSDI) score > 12 or corneal staining grade > 1 (in either eye) who underwent dry eye treatment with topical cyclosporine 0.1% in chondroitin sulfate emulsion (Klarity-C, ImprimisRx) for 3 months. Postoperative evaluation included comparison of the changes in OSDI score and corneal staining grade after 3 months of treatment from baseline.Results: From baseline to 3 months, a statistically significant improvement in mean OSDI scores (38.19 vs 24.18, p < 0.001) as well as mean corneal staining grade (3.62 vs 2.20, p < 0.001) was observed. The proportion of subjects with severe dry eye decreased from 62% to 20% and more than one-third (34%) of patients were in the normal OSDI range. The percentage of eyes with corneal staining grade of 2 or 3 decreased from 21% (baseline) to 8% at 3 months; 50% of the eyes had corneal staining grade of 0. The treatment was found to be safe with no adverse events observed in the study.Conclusion: Dry eye treatment with twice daily cyclosporine 0.1% in chondroitin sulfate emulsion was found to be safe and effective in reducing signs and symptoms of dry eye.Keywords: dry eye treatment, dry eye disease, cyclosporine 0.1%, Klarity-C, immunosuppressive agent DEDMatossian CTrattler WLoh JDove Medical Pressarticledry eye treatmentdry eye diseasecyclosporine 0.1%klarity-cimmunosuppressive agent dedOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 15, Pp 1979-1984 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	dry eye treatment dry eye disease cyclosporine 0.1% klarity-c immunosuppressive agent ded Ophthalmology RE1-994
spellingShingle	dry eye treatment dry eye disease cyclosporine 0.1% klarity-c immunosuppressive agent ded Ophthalmology RE1-994 Matossian C Trattler W Loh J Dry Eye Treatment with Topical Cyclosporine 0.1% in Chondroitin Sulfate Ophthalmic Emulsion
description	Cynthia Matossian,1 William Trattler,2 Jennifer Loh3 1Matossian Eye Associates, Pennington, NJ, USA; 2Center for Excellence in Eye Care, Miami, FL, USA; 3Loh Ophthalmology Associates, Miami, FL, USACorrespondence: Cynthia MatossianMatossian Eye Associates, 2 Capital Way, Ste 326, Pennington, NJ, 08534, USATel +1 215-230-9200Email cmatossian@cmassociatesllc.netPurpose: To evaluate the efficacy of topical cyclosporine 0.1% in chondroitin sulfate emulsion for the treatment of dry eye.Methods: This retrospective multicenter study included 100 eyes of 50 dry eye patients aged ≥ 18 years, with preoperative ocular surface disease index (OSDI) score > 12 or corneal staining grade > 1 (in either eye) who underwent dry eye treatment with topical cyclosporine 0.1% in chondroitin sulfate emulsion (Klarity-C, ImprimisRx) for 3 months. Postoperative evaluation included comparison of the changes in OSDI score and corneal staining grade after 3 months of treatment from baseline.Results: From baseline to 3 months, a statistically significant improvement in mean OSDI scores (38.19 vs 24.18, p < 0.001) as well as mean corneal staining grade (3.62 vs 2.20, p < 0.001) was observed. The proportion of subjects with severe dry eye decreased from 62% to 20% and more than one-third (34%) of patients were in the normal OSDI range. The percentage of eyes with corneal staining grade of 2 or 3 decreased from 21% (baseline) to 8% at 3 months; 50% of the eyes had corneal staining grade of 0. The treatment was found to be safe with no adverse events observed in the study.Conclusion: Dry eye treatment with twice daily cyclosporine 0.1% in chondroitin sulfate emulsion was found to be safe and effective in reducing signs and symptoms of dry eye.Keywords: dry eye treatment, dry eye disease, cyclosporine 0.1%, Klarity-C, immunosuppressive agent DED
format	article
author	Matossian C Trattler W Loh J
author_facet	Matossian C Trattler W Loh J
author_sort	Matossian C
title	Dry Eye Treatment with Topical Cyclosporine 0.1% in Chondroitin Sulfate Ophthalmic Emulsion
title_short	Dry Eye Treatment with Topical Cyclosporine 0.1% in Chondroitin Sulfate Ophthalmic Emulsion
title_full	Dry Eye Treatment with Topical Cyclosporine 0.1% in Chondroitin Sulfate Ophthalmic Emulsion
title_fullStr	Dry Eye Treatment with Topical Cyclosporine 0.1% in Chondroitin Sulfate Ophthalmic Emulsion
title_full_unstemmed	Dry Eye Treatment with Topical Cyclosporine 0.1% in Chondroitin Sulfate Ophthalmic Emulsion
title_sort	dry eye treatment with topical cyclosporine 0.1% in chondroitin sulfate ophthalmic emulsion
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/7cf29abbb2cd433e95fbb7a304bc8c4e
work_keys_str_mv	AT matossianc dryeyetreatmentwithtopicalcyclosporine01inchondroitinsulfateophthalmicemulsion AT trattlerw dryeyetreatmentwithtopicalcyclosporine01inchondroitinsulfateophthalmicemulsion AT lohj dryeyetreatmentwithtopicalcyclosporine01inchondroitinsulfateophthalmicemulsion
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Dry Eye Treatment with Topical Cyclosporine 0.1% in Chondroitin Sulfate Ophthalmic Emulsion

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