Branch flow distribution approach and its application in the calculation of fractional flow reserve in stenotic coronary artery
Objective: To calculate fractional flow reserve (FFR) based on computed tomography angiography (i.e., FFRCT) by considering the branch flow distribution in the coronary arteries. Background: FFR is the gold standard to diagnose myocardial ischemia caused by coronary stenosis. An accurate and no...
Guardado en:
| Autores principales: | , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
AIMS Press
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/7cf453ee35c640c098aa2425c53cf0c2 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:7cf453ee35c640c098aa2425c53cf0c2 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:7cf453ee35c640c098aa2425c53cf0c22021-11-09T05:58:56ZBranch flow distribution approach and its application in the calculation of fractional flow reserve in stenotic coronary artery10.3934/mbe.20212991551-0018https://doaj.org/article/7cf453ee35c640c098aa2425c53cf0c22021-07-01T00:00:00Zhttps://www.aimspress.com/article/doi/10.3934/mbe.2021299?viewType=HTMLhttps://doaj.org/toc/1551-0018Objective: To calculate fractional flow reserve (FFR) based on computed tomography angiography (i.e., FFRCT) by considering the branch flow distribution in the coronary arteries. Background: FFR is the gold standard to diagnose myocardial ischemia caused by coronary stenosis. An accurate and noninvasive method for obtaining total coronary blood flow is needed for the calculation of FFRCT. Methods: A mathematical model for estimating the coronary blood flow rate and two approaches for setting the patient-specific flow boundary condition were proposed. Coronary branch flow distribution methods based on a volume-flow approach and a diameter-flow approach were employed for the numerical simulation of FFRCT. The values of simulated FFRCT for 16 patients were compared with their clinically measured FFR. Results: The ratio of total coronary blood flow to cardiac output and the myocardial blood flow under the condition of hyperemia were 16.97% and 4.07 mL/min/g, respectively. The errors of FFRCT compared with clinical data under the volume-flow approach and diameter-flow approach were 10.47% and 11.76%, respectively, the diagnostic accuracies of FFRCT were 65% and 85%, and the consistencies were 95% and 90%. Conclusions: The mathematical model for estimating the coronary blood flow rate and the coronary branch flow distribution method can be applied to calculate the value of clinical noninvasive FFRCT.Honghui ZhangJun XiaYinlong YangQingqing YangHongfang Song Jinjie Xie Yue MaYang HouAike Qiao AIMS Pressarticlecoronary artery diseasehemodynamicsendovascular interventioncatheterizationdiagnosisBiotechnologyTP248.13-248.65MathematicsQA1-939ENMathematical Biosciences and Engineering, Vol 18, Iss 5, Pp 5978-5994 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
coronary artery disease hemodynamics endovascular intervention catheterization diagnosis Biotechnology TP248.13-248.65 Mathematics QA1-939 |
| spellingShingle |
coronary artery disease hemodynamics endovascular intervention catheterization diagnosis Biotechnology TP248.13-248.65 Mathematics QA1-939 Honghui Zhang Jun Xia Yinlong Yang Qingqing Yang Hongfang Song Jinjie Xie Yue Ma Yang Hou Aike Qiao Branch flow distribution approach and its application in the calculation of fractional flow reserve in stenotic coronary artery |
| description |
Objective:
To calculate fractional flow reserve (FFR) based on computed tomography angiography (i.e., FFRCT) by considering the branch flow distribution in the coronary arteries.
Background:
FFR is the gold standard to diagnose myocardial ischemia caused by coronary stenosis. An accurate and noninvasive method for obtaining total coronary blood flow is needed for the calculation of FFRCT.
Methods:
A mathematical model for estimating the coronary blood flow rate and two approaches for setting the patient-specific flow boundary condition were proposed. Coronary branch flow distribution methods based on a volume-flow approach and a diameter-flow approach were employed for the numerical simulation of FFRCT. The values of simulated FFRCT for 16 patients were compared with their clinically measured FFR.
Results:
The ratio of total coronary blood flow to cardiac output and the myocardial blood flow under the condition of hyperemia were 16.97% and 4.07 mL/min/g, respectively. The errors of FFRCT compared with clinical data under the volume-flow approach and diameter-flow approach were 10.47% and 11.76%, respectively, the diagnostic accuracies of FFRCT were 65% and 85%, and the consistencies were 95% and 90%.
Conclusions:
The mathematical model for estimating the coronary blood flow rate and the coronary branch flow distribution method can be applied to calculate the value of clinical noninvasive FFRCT. |
| format |
article |
| author |
Honghui Zhang Jun Xia Yinlong Yang Qingqing Yang Hongfang Song Jinjie Xie Yue Ma Yang Hou Aike Qiao |
| author_facet |
Honghui Zhang Jun Xia Yinlong Yang Qingqing Yang Hongfang Song Jinjie Xie Yue Ma Yang Hou Aike Qiao |
| author_sort |
Honghui Zhang |
| title |
Branch flow distribution approach and its application in the calculation of fractional flow reserve in stenotic coronary artery |
| title_short |
Branch flow distribution approach and its application in the calculation of fractional flow reserve in stenotic coronary artery |
| title_full |
Branch flow distribution approach and its application in the calculation of fractional flow reserve in stenotic coronary artery |
| title_fullStr |
Branch flow distribution approach and its application in the calculation of fractional flow reserve in stenotic coronary artery |
| title_full_unstemmed |
Branch flow distribution approach and its application in the calculation of fractional flow reserve in stenotic coronary artery |
| title_sort |
branch flow distribution approach and its application in the calculation of fractional flow reserve in stenotic coronary artery |
| publisher |
AIMS Press |
| publishDate |
2021 |
| url |
https://doaj.org/article/7cf453ee35c640c098aa2425c53cf0c2 |
| work_keys_str_mv |
AT honghuizhang branchflowdistributionapproachanditsapplicationinthecalculationoffractionalflowreserveinstenoticcoronaryartery AT junxia branchflowdistributionapproachanditsapplicationinthecalculationoffractionalflowreserveinstenoticcoronaryartery AT yinlongyang branchflowdistributionapproachanditsapplicationinthecalculationoffractionalflowreserveinstenoticcoronaryartery AT qingqingyang branchflowdistributionapproachanditsapplicationinthecalculationoffractionalflowreserveinstenoticcoronaryartery AT hongfangsong branchflowdistributionapproachanditsapplicationinthecalculationoffractionalflowreserveinstenoticcoronaryartery AT jinjiexie branchflowdistributionapproachanditsapplicationinthecalculationoffractionalflowreserveinstenoticcoronaryartery AT yuema branchflowdistributionapproachanditsapplicationinthecalculationoffractionalflowreserveinstenoticcoronaryartery AT yanghou branchflowdistributionapproachanditsapplicationinthecalculationoffractionalflowreserveinstenoticcoronaryartery AT aikeqiao branchflowdistributionapproachanditsapplicationinthecalculationoffractionalflowreserveinstenoticcoronaryartery |
| _version_ |
1718441308216885248 |