INTERRELATION OF STEROID RECEPTOR GENE EXPRESSION IN UTERINE TISSUES AND SERUM CONCENTRATIONS OF IMMUNOREGULATORY PROTEINS, CYTOKINES, SEX STEROIDS IN PROLIFERATIVE DISEASES

Pathogenetic mechanisms of uterine leiomyoma, adenomyosis and their combination are complicated and poorly understood, a differential diagnosis of leiomyosarcoma of the uterus is difficult. Our study aimed for a comparative analysis of the serum contents of α2-MG, PAG, some cytokines, sex steroids a...

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Autores principales:	S. V. Shramko, V. N. Zorina, N. A. Zorin, I. A. Botvinyeva, S. V. Arkhipova, V. V. Likhacheva
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2018
Materias:	leiomyoma steroid receptor genes cytokine alpha2-macroglobulin Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/7cf550c982aa40b1834681bd949d42cf
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spelling	oai:doaj.org-article:7cf550c982aa40b1834681bd949d42cf2021-11-18T08:03:47ZINTERRELATION OF STEROID RECEPTOR GENE EXPRESSION IN UTERINE TISSUES AND SERUM CONCENTRATIONS OF IMMUNOREGULATORY PROTEINS, CYTOKINES, SEX STEROIDS IN PROLIFERATIVE DISEASES1563-06252313-741X10.15789/1563-0625-2018-5-731-738https://doaj.org/article/7cf550c982aa40b1834681bd949d42cf2018-11-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1641https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XPathogenetic mechanisms of uterine leiomyoma, adenomyosis and their combination are complicated and poorly understood, a differential diagnosis of leiomyosarcoma of the uterus is difficult. Our study aimed for a comparative analysis of the serum contents of α2-MG, PAG, some cytokines, sex steroids and the expression of steroid receptor genes in the patients with different variants of uterine proliferative diseases, in order to determine their pathological role, diagnostic and prognostic value. Expression of estrogen receptor genes adenomyosis nodes was 1.5 to 2-fold higher than in leiomyoma, the combined pathology showed intermediate values, and expression of ER and PGR genes in leiomyosarcoma was minimal. In cellular leiomyoma, expression of ER receptor genes in the surrounding myometrium was 2 to 3-fold higher than in cases of simple leiomyomas. At the same time, concentration of estrogen and progesterone in the blood is comparable between the groups and control groups. All the patients have a deficiency of immunomodulatory α2-MG (12-13% for leiomyomas, 20% for adenomyosis, and 23% for malignant pathology). The concentration of immunosuppressive PAG is increased in combined conditions and leiomyosarcoma. In addition, the contents of IL-6 and TNFα increase, the VEGF levels exceed normal values 4 to 4.5-fold, in leiomyoma, 5.5-fold, in combined pathology, 6.5, in adenomyosis, and 10-fold, in leiomyosarcoma.The obtained results confirm that immunomodulatory proteins, cytokines and cell-targeting sex hormones exert an interdependent influence upon each other in the studied diseases, and their significant changes may be used in diagnostics and prognosis.S. V. ShramkoV. N. ZorinaN. A. ZorinI. A. BotvinyevaS. V. ArkhipovaV. V. LikhachevaSPb RAACIarticleleiomyomasteroid receptor genescytokinealpha2-macroglobulinImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 20, Iss 5, Pp 731-738 (2018)
institution	DOAJ
collection	DOAJ
language	RU
topic	leiomyoma steroid receptor genes cytokine alpha2-macroglobulin Immunologic diseases. Allergy RC581-607
spellingShingle	leiomyoma steroid receptor genes cytokine alpha2-macroglobulin Immunologic diseases. Allergy RC581-607 S. V. Shramko V. N. Zorina N. A. Zorin I. A. Botvinyeva S. V. Arkhipova V. V. Likhacheva INTERRELATION OF STEROID RECEPTOR GENE EXPRESSION IN UTERINE TISSUES AND SERUM CONCENTRATIONS OF IMMUNOREGULATORY PROTEINS, CYTOKINES, SEX STEROIDS IN PROLIFERATIVE DISEASES
description	Pathogenetic mechanisms of uterine leiomyoma, adenomyosis and their combination are complicated and poorly understood, a differential diagnosis of leiomyosarcoma of the uterus is difficult. Our study aimed for a comparative analysis of the serum contents of α2-MG, PAG, some cytokines, sex steroids and the expression of steroid receptor genes in the patients with different variants of uterine proliferative diseases, in order to determine their pathological role, diagnostic and prognostic value. Expression of estrogen receptor genes adenomyosis nodes was 1.5 to 2-fold higher than in leiomyoma, the combined pathology showed intermediate values, and expression of ER and PGR genes in leiomyosarcoma was minimal. In cellular leiomyoma, expression of ER receptor genes in the surrounding myometrium was 2 to 3-fold higher than in cases of simple leiomyomas. At the same time, concentration of estrogen and progesterone in the blood is comparable between the groups and control groups. All the patients have a deficiency of immunomodulatory α2-MG (12-13% for leiomyomas, 20% for adenomyosis, and 23% for malignant pathology). The concentration of immunosuppressive PAG is increased in combined conditions and leiomyosarcoma. In addition, the contents of IL-6 and TNFα increase, the VEGF levels exceed normal values 4 to 4.5-fold, in leiomyoma, 5.5-fold, in combined pathology, 6.5, in adenomyosis, and 10-fold, in leiomyosarcoma.The obtained results confirm that immunomodulatory proteins, cytokines and cell-targeting sex hormones exert an interdependent influence upon each other in the studied diseases, and their significant changes may be used in diagnostics and prognosis.
format	article
author	S. V. Shramko V. N. Zorina N. A. Zorin I. A. Botvinyeva S. V. Arkhipova V. V. Likhacheva
author_facet	S. V. Shramko V. N. Zorina N. A. Zorin I. A. Botvinyeva S. V. Arkhipova V. V. Likhacheva
author_sort	S. V. Shramko
title	INTERRELATION OF STEROID RECEPTOR GENE EXPRESSION IN UTERINE TISSUES AND SERUM CONCENTRATIONS OF IMMUNOREGULATORY PROTEINS, CYTOKINES, SEX STEROIDS IN PROLIFERATIVE DISEASES
title_short	INTERRELATION OF STEROID RECEPTOR GENE EXPRESSION IN UTERINE TISSUES AND SERUM CONCENTRATIONS OF IMMUNOREGULATORY PROTEINS, CYTOKINES, SEX STEROIDS IN PROLIFERATIVE DISEASES
title_full	INTERRELATION OF STEROID RECEPTOR GENE EXPRESSION IN UTERINE TISSUES AND SERUM CONCENTRATIONS OF IMMUNOREGULATORY PROTEINS, CYTOKINES, SEX STEROIDS IN PROLIFERATIVE DISEASES
title_fullStr	INTERRELATION OF STEROID RECEPTOR GENE EXPRESSION IN UTERINE TISSUES AND SERUM CONCENTRATIONS OF IMMUNOREGULATORY PROTEINS, CYTOKINES, SEX STEROIDS IN PROLIFERATIVE DISEASES
title_full_unstemmed	INTERRELATION OF STEROID RECEPTOR GENE EXPRESSION IN UTERINE TISSUES AND SERUM CONCENTRATIONS OF IMMUNOREGULATORY PROTEINS, CYTOKINES, SEX STEROIDS IN PROLIFERATIVE DISEASES
title_sort	interrelation of steroid receptor gene expression in uterine tissues and serum concentrations of immunoregulatory proteins, cytokines, sex steroids in proliferative diseases
publisher	SPb RAACI
publishDate	2018
url	https://doaj.org/article/7cf550c982aa40b1834681bd949d42cf
work_keys_str_mv	AT svshramko interrelationofsteroidreceptorgeneexpressioninuterinetissuesandserumconcentrationsofimmunoregulatoryproteinscytokinessexsteroidsinproliferativediseases AT vnzorina interrelationofsteroidreceptorgeneexpressioninuterinetissuesandserumconcentrationsofimmunoregulatoryproteinscytokinessexsteroidsinproliferativediseases AT nazorin interrelationofsteroidreceptorgeneexpressioninuterinetissuesandserumconcentrationsofimmunoregulatoryproteinscytokinessexsteroidsinproliferativediseases AT iabotvinyeva interrelationofsteroidreceptorgeneexpressioninuterinetissuesandserumconcentrationsofimmunoregulatoryproteinscytokinessexsteroidsinproliferativediseases AT svarkhipova interrelationofsteroidreceptorgeneexpressioninuterinetissuesandserumconcentrationsofimmunoregulatoryproteinscytokinessexsteroidsinproliferativediseases AT vvlikhacheva interrelationofsteroidreceptorgeneexpressioninuterinetissuesandserumconcentrationsofimmunoregulatoryproteinscytokinessexsteroidsinproliferativediseases
_version_	1718422362198638592

INTERRELATION OF STEROID RECEPTOR GENE EXPRESSION IN UTERINE TISSUES AND SERUM CONCENTRATIONS OF IMMUNOREGULATORY PROTEINS, CYTOKINES, SEX STEROIDS IN PROLIFERATIVE DISEASES

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