Age- and sex-related variations in platelet count in Italy: a proposal of reference ranges based on 40987 subjects' data.

<h4>Background and objectives</h4>Although several studies demonstrated that platelet count is higher in women, decreases with age, and is influenced by genetic background, most clinical laboratories still use the reference interval 150-400×10(9) platelets/L for all subjects. The present...

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Autores principales: Ginevra Biino, Iolanda Santimone, Cosetta Minelli, Rossella Sorice, Bruno Frongia, Michela Traglia, Sheila Ulivi, Augusto Di Castelnuovo, Martin Gögele, Teresa Nutile, Marcella Francavilla, Cinzia Sala, Nicola Pirastu, Chiara Cerletti, Licia Iacoviello, Paolo Gasparini, Daniela Toniolo, Marina Ciullo, Peter Pramstaller, Mario Pirastu, Giovanni de Gaetano, Carlo L Balduini
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Publicado: Public Library of Science (PLoS) 2013
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spelling oai:doaj.org-article:7cfa15a8a75b41869bdad94b70cf21192021-11-18T07:59:16ZAge- and sex-related variations in platelet count in Italy: a proposal of reference ranges based on 40987 subjects' data.1932-620310.1371/journal.pone.0054289https://doaj.org/article/7cfa15a8a75b41869bdad94b70cf21192013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23382888/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background and objectives</h4>Although several studies demonstrated that platelet count is higher in women, decreases with age, and is influenced by genetic background, most clinical laboratories still use the reference interval 150-400×10(9) platelets/L for all subjects. The present study was to identify age- and sex-specific reference intervals for platelet count.<h4>Methods</h4>We analysed electronic records of subjects enrolled in three population-based studies that investigated inhabitants of seven Italian areas including six geographic isolates. After exclusion of patients with malignancies, liver diseases, or inherited thrombocytopenias, which could affect platelet count, reference intervals were estimated from 40,987 subjects with the non parametric method computing the 2.5° and 97.5° percentiles.<h4>Results</h4>Platelet count was similar in men and women until the age of 14, but subsequently women had steadily more platelets than men. The number of platelets decreases quickly in childhood, stabilizes in adulthood, and further decreases in oldness. The final result of this phenomenon is that platelet count in old age was reduced by 35% in men and by 25% in women compared with early infancy. Based on these findings, we estimated reference intervals for platelet count ×10(9)/L in children (176-452), adult men (141-362), adult women (156-405), old men (122-350) and, old women (140-379). Moreover, we calculated an "extended" reference interval that takes into account the differences in platelet count observed in different geographic areas.<h4>Conclusions</h4>The age-, sex-, and origin-related variability of platelet count is very wide, and the patient-adapted reference intervals we propose change the thresholds for diagnosing both thrombocytopenia and thrombocytosis in Italy.Ginevra BiinoIolanda SantimoneCosetta MinelliRossella SoriceBruno FrongiaMichela TragliaSheila UliviAugusto Di CastelnuovoMartin GögeleTeresa NutileMarcella FrancavillaCinzia SalaNicola PirastuChiara CerlettiLicia IacovielloPaolo GaspariniDaniela TonioloMarina CiulloPeter PramstallerMario PirastuGiovanni de GaetanoCarlo L BalduiniPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 1, p e54289 (2013)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Ginevra Biino
Iolanda Santimone
Cosetta Minelli
Rossella Sorice
Bruno Frongia
Michela Traglia
Sheila Ulivi
Augusto Di Castelnuovo
Martin Gögele
Teresa Nutile
Marcella Francavilla
Cinzia Sala
Nicola Pirastu
Chiara Cerletti
Licia Iacoviello
Paolo Gasparini
Daniela Toniolo
Marina Ciullo
Peter Pramstaller
Mario Pirastu
Giovanni de Gaetano
Carlo L Balduini
Age- and sex-related variations in platelet count in Italy: a proposal of reference ranges based on 40987 subjects' data.
description <h4>Background and objectives</h4>Although several studies demonstrated that platelet count is higher in women, decreases with age, and is influenced by genetic background, most clinical laboratories still use the reference interval 150-400×10(9) platelets/L for all subjects. The present study was to identify age- and sex-specific reference intervals for platelet count.<h4>Methods</h4>We analysed electronic records of subjects enrolled in three population-based studies that investigated inhabitants of seven Italian areas including six geographic isolates. After exclusion of patients with malignancies, liver diseases, or inherited thrombocytopenias, which could affect platelet count, reference intervals were estimated from 40,987 subjects with the non parametric method computing the 2.5° and 97.5° percentiles.<h4>Results</h4>Platelet count was similar in men and women until the age of 14, but subsequently women had steadily more platelets than men. The number of platelets decreases quickly in childhood, stabilizes in adulthood, and further decreases in oldness. The final result of this phenomenon is that platelet count in old age was reduced by 35% in men and by 25% in women compared with early infancy. Based on these findings, we estimated reference intervals for platelet count ×10(9)/L in children (176-452), adult men (141-362), adult women (156-405), old men (122-350) and, old women (140-379). Moreover, we calculated an "extended" reference interval that takes into account the differences in platelet count observed in different geographic areas.<h4>Conclusions</h4>The age-, sex-, and origin-related variability of platelet count is very wide, and the patient-adapted reference intervals we propose change the thresholds for diagnosing both thrombocytopenia and thrombocytosis in Italy.
format article
author Ginevra Biino
Iolanda Santimone
Cosetta Minelli
Rossella Sorice
Bruno Frongia
Michela Traglia
Sheila Ulivi
Augusto Di Castelnuovo
Martin Gögele
Teresa Nutile
Marcella Francavilla
Cinzia Sala
Nicola Pirastu
Chiara Cerletti
Licia Iacoviello
Paolo Gasparini
Daniela Toniolo
Marina Ciullo
Peter Pramstaller
Mario Pirastu
Giovanni de Gaetano
Carlo L Balduini
author_facet Ginevra Biino
Iolanda Santimone
Cosetta Minelli
Rossella Sorice
Bruno Frongia
Michela Traglia
Sheila Ulivi
Augusto Di Castelnuovo
Martin Gögele
Teresa Nutile
Marcella Francavilla
Cinzia Sala
Nicola Pirastu
Chiara Cerletti
Licia Iacoviello
Paolo Gasparini
Daniela Toniolo
Marina Ciullo
Peter Pramstaller
Mario Pirastu
Giovanni de Gaetano
Carlo L Balduini
author_sort Ginevra Biino
title Age- and sex-related variations in platelet count in Italy: a proposal of reference ranges based on 40987 subjects' data.
title_short Age- and sex-related variations in platelet count in Italy: a proposal of reference ranges based on 40987 subjects' data.
title_full Age- and sex-related variations in platelet count in Italy: a proposal of reference ranges based on 40987 subjects' data.
title_fullStr Age- and sex-related variations in platelet count in Italy: a proposal of reference ranges based on 40987 subjects' data.
title_full_unstemmed Age- and sex-related variations in platelet count in Italy: a proposal of reference ranges based on 40987 subjects' data.
title_sort age- and sex-related variations in platelet count in italy: a proposal of reference ranges based on 40987 subjects' data.
publisher Public Library of Science (PLoS)
publishDate 2013
url https://doaj.org/article/7cfa15a8a75b41869bdad94b70cf2119
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