Primer synthesis by a eukaryotic-like archaeal primase is independent of its Fe-S cluster

Primase is the specialised DNA-dependent RNA polymerase responsible for the initiation of DNA synthesis during DNA replication. Here the authors use a structural biology approach to identify the initiation site in the S. solfataricus PriSLX primase and to demonstrate that its Fe-S cluster is dispens...

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Autores principales:	Sandro Holzer, Jiangyu Yan, Mairi L. Kilkenny, Stephen D. Bell, Luca Pellegrini
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7cfdb2fe31884bb48802905f35b30707
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spelling	oai:doaj.org-article:7cfdb2fe31884bb48802905f35b307072021-12-02T17:06:22ZPrimer synthesis by a eukaryotic-like archaeal primase is independent of its Fe-S cluster10.1038/s41467-017-01707-w2041-1723https://doaj.org/article/7cfdb2fe31884bb48802905f35b307072017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01707-whttps://doaj.org/toc/2041-1723Primase is the specialised DNA-dependent RNA polymerase responsible for the initiation of DNA synthesis during DNA replication. Here the authors use a structural biology approach to identify the initiation site in the S. solfataricus PriSLX primase and to demonstrate that its Fe-S cluster is dispensable for primer synthesis.Sandro HolzerJiangyu YanMairi L. KilkennyStephen D. BellLuca PellegriniNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sandro Holzer Jiangyu Yan Mairi L. Kilkenny Stephen D. Bell Luca Pellegrini Primer synthesis by a eukaryotic-like archaeal primase is independent of its Fe-S cluster
description	Primase is the specialised DNA-dependent RNA polymerase responsible for the initiation of DNA synthesis during DNA replication. Here the authors use a structural biology approach to identify the initiation site in the S. solfataricus PriSLX primase and to demonstrate that its Fe-S cluster is dispensable for primer synthesis.
format	article
author	Sandro Holzer Jiangyu Yan Mairi L. Kilkenny Stephen D. Bell Luca Pellegrini
author_facet	Sandro Holzer Jiangyu Yan Mairi L. Kilkenny Stephen D. Bell Luca Pellegrini
author_sort	Sandro Holzer
title	Primer synthesis by a eukaryotic-like archaeal primase is independent of its Fe-S cluster
title_short	Primer synthesis by a eukaryotic-like archaeal primase is independent of its Fe-S cluster
title_full	Primer synthesis by a eukaryotic-like archaeal primase is independent of its Fe-S cluster
title_fullStr	Primer synthesis by a eukaryotic-like archaeal primase is independent of its Fe-S cluster
title_full_unstemmed	Primer synthesis by a eukaryotic-like archaeal primase is independent of its Fe-S cluster
title_sort	primer synthesis by a eukaryotic-like archaeal primase is independent of its fe-s cluster
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7cfdb2fe31884bb48802905f35b30707
work_keys_str_mv	AT sandroholzer primersynthesisbyaeukaryoticlikearchaealprimaseisindependentofitsfescluster AT jiangyuyan primersynthesisbyaeukaryoticlikearchaealprimaseisindependentofitsfescluster AT mairilkilkenny primersynthesisbyaeukaryoticlikearchaealprimaseisindependentofitsfescluster AT stephendbell primersynthesisbyaeukaryoticlikearchaealprimaseisindependentofitsfescluster AT lucapellegrini primersynthesisbyaeukaryoticlikearchaealprimaseisindependentofitsfescluster
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Primer synthesis by a eukaryotic-like archaeal primase is independent of its Fe-S cluster

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