Primer synthesis by a eukaryotic-like archaeal primase is independent of its Fe-S cluster

Primer synthesis by a eukaryotic-like archaeal primase is independent of its Fe-S cluster

Primase is the specialised DNA-dependent RNA polymerase responsible for the initiation of DNA synthesis during DNA replication. Here the authors use a structural biology approach to identify the initiation site in the S. solfataricus PriSLX primase and to demonstrate that its Fe-S cluster is dispens...

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Autores principales: Sandro Holzer, Jiangyu Yan, Mairi L. Kilkenny, Stephen D. Bell, Luca Pellegrini
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
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Acceso en línea:https://doaj.org/article/7cfdb2fe31884bb48802905f35b30707
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