Cross-species gene modules emerge from a systems biology approach to osteoarthritis

Joint degeneration: linking animal and human disease Cartilage, and other tissues in our joints, begins to degenerate with age resulting in pain and reduced mobility; this is termed osteoarthritis (OA). To understand OA better researchers have often used animal models to represent this disease; howe...

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Autores principales:	Alan James Mueller, Elizabeth G. Canty-Laird, Peter D. Clegg, Simon R. Tew
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/7cfff89113c548ac876d61f364504387
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spelling	oai:doaj.org-article:7cfff89113c548ac876d61f3645043872021-12-02T16:08:59ZCross-species gene modules emerge from a systems biology approach to osteoarthritis10.1038/s41540-017-0014-32056-7189https://doaj.org/article/7cfff89113c548ac876d61f3645043872017-05-01T00:00:00Zhttps://doi.org/10.1038/s41540-017-0014-3https://doaj.org/toc/2056-7189Joint degeneration: linking animal and human disease Cartilage, and other tissues in our joints, begins to degenerate with age resulting in pain and reduced mobility; this is termed osteoarthritis (OA). To understand OA better researchers have often used animal models to represent this disease; however, these models have never been fully-evaluated against human cartilage. This study considered the messages produced by cartilage cells in both humans and rats. Using a method that creates a network of messages the study was able to define “blocks” of cell messages that were associated with diseased cartilage in both the rat and human. As part of this study the authors also defined a set of messages that could be used to distinguish healthy and disease cartilage. In this way it may be possible to define patients with early OA that may benefit from therapeutic interventions. (135)Alan James MuellerElizabeth G. Canty-LairdPeter D. CleggSimon R. TewNature PortfolioarticleBiology (General)QH301-705.5ENnpj Systems Biology and Applications, Vol 3, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Alan James Mueller Elizabeth G. Canty-Laird Peter D. Clegg Simon R. Tew Cross-species gene modules emerge from a systems biology approach to osteoarthritis
description	Joint degeneration: linking animal and human disease Cartilage, and other tissues in our joints, begins to degenerate with age resulting in pain and reduced mobility; this is termed osteoarthritis (OA). To understand OA better researchers have often used animal models to represent this disease; however, these models have never been fully-evaluated against human cartilage. This study considered the messages produced by cartilage cells in both humans and rats. Using a method that creates a network of messages the study was able to define “blocks” of cell messages that were associated with diseased cartilage in both the rat and human. As part of this study the authors also defined a set of messages that could be used to distinguish healthy and disease cartilage. In this way it may be possible to define patients with early OA that may benefit from therapeutic interventions. (135)
format	article
author	Alan James Mueller Elizabeth G. Canty-Laird Peter D. Clegg Simon R. Tew
author_facet	Alan James Mueller Elizabeth G. Canty-Laird Peter D. Clegg Simon R. Tew
author_sort	Alan James Mueller
title	Cross-species gene modules emerge from a systems biology approach to osteoarthritis
title_short	Cross-species gene modules emerge from a systems biology approach to osteoarthritis
title_full	Cross-species gene modules emerge from a systems biology approach to osteoarthritis
title_fullStr	Cross-species gene modules emerge from a systems biology approach to osteoarthritis
title_full_unstemmed	Cross-species gene modules emerge from a systems biology approach to osteoarthritis
title_sort	cross-species gene modules emerge from a systems biology approach to osteoarthritis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7cfff89113c548ac876d61f364504387
work_keys_str_mv	AT alanjamesmueller crossspeciesgenemodulesemergefromasystemsbiologyapproachtoosteoarthritis AT elizabethgcantylaird crossspeciesgenemodulesemergefromasystemsbiologyapproachtoosteoarthritis AT peterdclegg crossspeciesgenemodulesemergefromasystemsbiologyapproachtoosteoarthritis AT simonrtew crossspeciesgenemodulesemergefromasystemsbiologyapproachtoosteoarthritis
_version_	1718384478612619264

Cross-species gene modules emerge from a systems biology approach to osteoarthritis

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