Identifying immunologically-vulnerable regions of the HCV E2 glycoprotein and broadly neutralizing antibodies that target them

A good vaccine should direct the immune response to virus regions that are most difficult to escape. Here, Quadeer et al. develop a predictive in-silico evolutionary model for HCV E2 which identifies one such antigenic region and identifies multiple broadly neutralizing human antibodies that appear...

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Autores principales:	Ahmed A. Quadeer, Raymond H. Y. Louie, Matthew R. McKay
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7d0192f5141f4854b0d85ff67a977c3e
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spelling	oai:doaj.org-article:7d0192f5141f4854b0d85ff67a977c3e2021-12-02T17:01:37ZIdentifying immunologically-vulnerable regions of the HCV E2 glycoprotein and broadly neutralizing antibodies that target them10.1038/s41467-019-09819-12041-1723https://doaj.org/article/7d0192f5141f4854b0d85ff67a977c3e2019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09819-1https://doaj.org/toc/2041-1723A good vaccine should direct the immune response to virus regions that are most difficult to escape. Here, Quadeer et al. develop a predictive in-silico evolutionary model for HCV E2 which identifies one such antigenic region and identifies multiple broadly neutralizing human antibodies that appear difficult to escape from.Ahmed A. QuadeerRaymond H. Y. LouieMatthew R. McKayNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ahmed A. Quadeer Raymond H. Y. Louie Matthew R. McKay Identifying immunologically-vulnerable regions of the HCV E2 glycoprotein and broadly neutralizing antibodies that target them
description	A good vaccine should direct the immune response to virus regions that are most difficult to escape. Here, Quadeer et al. develop a predictive in-silico evolutionary model for HCV E2 which identifies one such antigenic region and identifies multiple broadly neutralizing human antibodies that appear difficult to escape from.
format	article
author	Ahmed A. Quadeer Raymond H. Y. Louie Matthew R. McKay
author_facet	Ahmed A. Quadeer Raymond H. Y. Louie Matthew R. McKay
author_sort	Ahmed A. Quadeer
title	Identifying immunologically-vulnerable regions of the HCV E2 glycoprotein and broadly neutralizing antibodies that target them
title_short	Identifying immunologically-vulnerable regions of the HCV E2 glycoprotein and broadly neutralizing antibodies that target them
title_full	Identifying immunologically-vulnerable regions of the HCV E2 glycoprotein and broadly neutralizing antibodies that target them
title_fullStr	Identifying immunologically-vulnerable regions of the HCV E2 glycoprotein and broadly neutralizing antibodies that target them
title_full_unstemmed	Identifying immunologically-vulnerable regions of the HCV E2 glycoprotein and broadly neutralizing antibodies that target them
title_sort	identifying immunologically-vulnerable regions of the hcv e2 glycoprotein and broadly neutralizing antibodies that target them
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/7d0192f5141f4854b0d85ff67a977c3e
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Identifying immunologically-vulnerable regions of the HCV E2 glycoprotein and broadly neutralizing antibodies that target them

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