Oral administration of n-3 fatty acids positively affect the mucosal lesions after experimental ischemic enteritis in the rat
Aim: The purpose of the study was to evaluate the effect of oral administration of n-3 polyunsaturated fatty acids in experimental ischemic enteritis in rats. Methods: Forty Wistar rats were submitted to control narrowing of the superior mesenteric artery and were divided in two groups: N3 polyunsat...
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oai:doaj.org-article:7d04c4031de1414b99413b3e5ea0c7b52021-12-01T20:36:14ZOral administration of n-3 fatty acids positively affect the mucosal lesions after experimental ischemic enteritis in the rat10.24875/CIRU.200010232444-054Xhttps://doaj.org/article/7d04c4031de1414b99413b3e5ea0c7b52021-01-01T00:00:00Zhttps://www.cirugiaycirujanos.com/frame_esp.php?id=581https://doaj.org/toc/2444-054XAim: The purpose of the study was to evaluate the effect of oral administration of n-3 polyunsaturated fatty acids in experimental ischemic enteritis in rats. Methods: Forty Wistar rats were submitted to control narrowing of the superior mesenteric artery and were divided in two groups: N3 polyunsaturated fatty acids, which received a high-molecular polymer solution of artificial total enteral nutrition enriched with n-3 fatty acids and CONTROL which received a high-molecular polymer solution of artificial total enteral nutrition. Results: Reduction of the animals’ body weight was observed in both groups, but there was no difference between the two groups. Regarding the level of cytokines interleukin (IL)-1b, IL-6, and tumor necrosis factor a (TNF-a) there was no statistically significant difference between the two groups. Ischemic lesions to the small bowel mucosa were observed in both groups. A statistically significant difference in the extent of intestinal lesions was observed between the two groups with the animals that received enteral nutrition enriched with n-3 fatty acid developing fewer lesions. Conclusion: Enteral nutrition enriched with n-3 polyunsaturated fatty acids reduces the mucosal lesions caused by mesenteric ischemia compared to standard enteral nutrition, by modifying the local, but not the systemic, immune, and inflammatory response. Zambia KoukouritakiIoannis MantzorosOrestis Ioannidis Styliani ParpoudiKonstantinos Galanos-DemirisPanagiotis ChristidisManousos G. PramateftakisEfstathios KotidisNikolaos OuzounidisCharalambos DimitriadisStamatios AngelopoulosPermanyerarticleCytokines. Immunonutrition. Intestinal ischemia. N-3 fatty acids. Small bowel. Ischemic enteritis.SurgeryRD1-811ENESCirugía y Cirujanos, Vol 89, Iss 6 (2021) |
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EN ES |
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Cytokines. Immunonutrition. Intestinal ischemia. N-3 fatty acids. Small bowel. Ischemic enteritis. Surgery RD1-811 |
| spellingShingle |
Cytokines. Immunonutrition. Intestinal ischemia. N-3 fatty acids. Small bowel. Ischemic enteritis. Surgery RD1-811 Zambia Koukouritaki Ioannis Mantzoros Orestis Ioannidis Styliani Parpoudi Konstantinos Galanos-Demiris Panagiotis Christidis Manousos G. Pramateftakis Efstathios Kotidis Nikolaos Ouzounidis Charalambos Dimitriadis Stamatios Angelopoulos Oral administration of n-3 fatty acids positively affect the mucosal lesions after experimental ischemic enteritis in the rat |
| description |
Aim: The purpose of the study was to evaluate the effect of oral administration of n-3 polyunsaturated fatty acids in experimental ischemic enteritis in rats. Methods: Forty Wistar rats were submitted to control narrowing of the superior mesenteric artery and were divided in two groups: N3 polyunsaturated fatty acids, which received a high-molecular polymer solution of artificial total enteral nutrition enriched with n-3 fatty acids and CONTROL which received a high-molecular polymer solution of artificial total enteral nutrition. Results: Reduction of the animals’ body weight was observed in both groups, but there was no difference between the two groups. Regarding the level of cytokines interleukin (IL)-1b, IL-6, and tumor necrosis factor a (TNF-a) there was no statistically significant difference between the two groups. Ischemic lesions to the small bowel mucosa were observed in both groups. A statistically significant difference in the extent of intestinal lesions was observed between the two groups with the animals that received enteral nutrition enriched with n-3 fatty acid developing fewer lesions. Conclusion: Enteral nutrition enriched with n-3 polyunsaturated fatty acids reduces the mucosal lesions caused by mesenteric ischemia compared to standard enteral nutrition, by modifying the local, but not the systemic, immune, and inflammatory response.
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| format |
article |
| author |
Zambia Koukouritaki Ioannis Mantzoros Orestis Ioannidis Styliani Parpoudi Konstantinos Galanos-Demiris Panagiotis Christidis Manousos G. Pramateftakis Efstathios Kotidis Nikolaos Ouzounidis Charalambos Dimitriadis Stamatios Angelopoulos |
| author_facet |
Zambia Koukouritaki Ioannis Mantzoros Orestis Ioannidis Styliani Parpoudi Konstantinos Galanos-Demiris Panagiotis Christidis Manousos G. Pramateftakis Efstathios Kotidis Nikolaos Ouzounidis Charalambos Dimitriadis Stamatios Angelopoulos |
| author_sort |
Zambia Koukouritaki |
| title |
Oral administration of n-3 fatty acids positively affect the mucosal lesions after experimental ischemic enteritis in the rat |
| title_short |
Oral administration of n-3 fatty acids positively affect the mucosal lesions after experimental ischemic enteritis in the rat |
| title_full |
Oral administration of n-3 fatty acids positively affect the mucosal lesions after experimental ischemic enteritis in the rat |
| title_fullStr |
Oral administration of n-3 fatty acids positively affect the mucosal lesions after experimental ischemic enteritis in the rat |
| title_full_unstemmed |
Oral administration of n-3 fatty acids positively affect the mucosal lesions after experimental ischemic enteritis in the rat |
| title_sort |
oral administration of n-3 fatty acids positively affect the mucosal lesions after experimental ischemic enteritis in the rat |
| publisher |
Permanyer |
| publishDate |
2021 |
| url |
https://doaj.org/article/7d04c4031de1414b99413b3e5ea0c7b5 |
| work_keys_str_mv |
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