Drug prescription appropriateness in the elderly: an Italian study

Nicola Allegri,1 Federica Rossi,2 Federica Del Signore,2 Paolo Bertazzoni,3 Roberto Bellazzi,4 Giorgio Sandrini,5 Tomaso Vecchi,1 Davide Liccione,1 Alessia Pascale,6 Stefano Govoni6 1Department of Brain and Behavioral Sciences, University of Pavia, 2Pavia and Vigevano Neuropsychological Center for...

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Autores principales:	Allegri N, Rossi F, Del Signore F, Bertazzoni P, Bellazzi R, Sandrini G, Vecchi T, Liccione D, Pascale A, Govoni S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Drug prescription Elderly Beers Criteria drug-drug interactions sedative load Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/7d0ba00ee5bb4c5b81e7bf62de094134
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spelling	oai:doaj.org-article:7d0ba00ee5bb4c5b81e7bf62de0941342021-12-02T04:40:51ZDrug prescription appropriateness in the elderly: an Italian study1178-1998https://doaj.org/article/7d0ba00ee5bb4c5b81e7bf62de0941342017-02-01T00:00:00Zhttps://www.dovepress.com/drug-prescription-appropriateness-in-the-elderly-an-italian-study-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Nicola Allegri,1 Federica Rossi,2 Federica Del Signore,2 Paolo Bertazzoni,3 Roberto Bellazzi,4 Giorgio Sandrini,5 Tomaso Vecchi,1 Davide Liccione,1 Alessia Pascale,6 Stefano Govoni6 1Department of Brain and Behavioral Sciences, University of Pavia, 2Pavia and Vigevano Neuropsychological Center for Alzheimer’s Disease, 3”Bertazzoni” Pharmacy General Partnership, Vigevano, 4Nephrology and Dialysis Ward, Civil Hospital of Vigevano, 5C. Mondino National Institute of Neurology Foundation, IRCCS, 6Department of Drug Sciences, Section of pharmacology, University of Pavia, Pavia, Italy Purpose: Correct drug prescription in the elderly is a difficult task that requires careful survey of the current pharmacological therapies. In this article, we reviewed the drug prescriptions provided to 860 persons aged 65 years or over, residing in a small city of Lombardy, Italy.Methods: Subjects were recruited from a local nursing home, the Pavia and Vigevano Neuropsychological Center for Alzheimer’s Disease, general practitioners’ offices, and the local University of the Third Age. For each patient, the amount of potentially inappropriate prescriptions (PIPs), sedative and anticholinergic load (SL and AL, respectively), and drug–drug interactions were evaluated.Results: Widespread polypharmacy, giving rise to 10.06% of PIPs in the whole collection of prescriptions, was observed. In particular, PIPs mainly concern drugs acting at the central nervous system level, mostly benzodiazepines and antipsychotics. Moreover, approximately one-fourth of the subjects had an elevated SL and approximately one-tenth a high AL. Drug–drug interactions were frequent (266 requiring medical attention), up to five for each single patient. Of concern was the underuse of antidementia drugs: only 20 patients received a cholinesterase inhibitor or memantine, although 183 patients were potentially suitable for this treatment.Conclusion: These results demonstrate the need to develop novel strategies aimed at improving the quality of drug prescription. Keywords: drug prescription, elderly, Beers criteria, drug–drug interactions, sedative loadAllegri NRossi FDel Signore FBertazzoni PBellazzi RSandrini GVecchi TLiccione DPascale AGovoni SDove Medical PressarticleDrug prescriptionElderlyBeers Criteriadrug-drug interactionssedative loadGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 12, Pp 325-333 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Drug prescription Elderly Beers Criteria drug-drug interactions sedative load Geriatrics RC952-954.6
spellingShingle	Drug prescription Elderly Beers Criteria drug-drug interactions sedative load Geriatrics RC952-954.6 Allegri N Rossi F Del Signore F Bertazzoni P Bellazzi R Sandrini G Vecchi T Liccione D Pascale A Govoni S Drug prescription appropriateness in the elderly: an Italian study
description	Nicola Allegri,1 Federica Rossi,2 Federica Del Signore,2 Paolo Bertazzoni,3 Roberto Bellazzi,4 Giorgio Sandrini,5 Tomaso Vecchi,1 Davide Liccione,1 Alessia Pascale,6 Stefano Govoni6 1Department of Brain and Behavioral Sciences, University of Pavia, 2Pavia and Vigevano Neuropsychological Center for Alzheimer’s Disease, 3”Bertazzoni” Pharmacy General Partnership, Vigevano, 4Nephrology and Dialysis Ward, Civil Hospital of Vigevano, 5C. Mondino National Institute of Neurology Foundation, IRCCS, 6Department of Drug Sciences, Section of pharmacology, University of Pavia, Pavia, Italy Purpose: Correct drug prescription in the elderly is a difficult task that requires careful survey of the current pharmacological therapies. In this article, we reviewed the drug prescriptions provided to 860 persons aged 65 years or over, residing in a small city of Lombardy, Italy.Methods: Subjects were recruited from a local nursing home, the Pavia and Vigevano Neuropsychological Center for Alzheimer’s Disease, general practitioners’ offices, and the local University of the Third Age. For each patient, the amount of potentially inappropriate prescriptions (PIPs), sedative and anticholinergic load (SL and AL, respectively), and drug–drug interactions were evaluated.Results: Widespread polypharmacy, giving rise to 10.06% of PIPs in the whole collection of prescriptions, was observed. In particular, PIPs mainly concern drugs acting at the central nervous system level, mostly benzodiazepines and antipsychotics. Moreover, approximately one-fourth of the subjects had an elevated SL and approximately one-tenth a high AL. Drug–drug interactions were frequent (266 requiring medical attention), up to five for each single patient. Of concern was the underuse of antidementia drugs: only 20 patients received a cholinesterase inhibitor or memantine, although 183 patients were potentially suitable for this treatment.Conclusion: These results demonstrate the need to develop novel strategies aimed at improving the quality of drug prescription. Keywords: drug prescription, elderly, Beers criteria, drug–drug interactions, sedative load
format	article
author	Allegri N Rossi F Del Signore F Bertazzoni P Bellazzi R Sandrini G Vecchi T Liccione D Pascale A Govoni S
author_facet	Allegri N Rossi F Del Signore F Bertazzoni P Bellazzi R Sandrini G Vecchi T Liccione D Pascale A Govoni S
author_sort	Allegri N
title	Drug prescription appropriateness in the elderly: an Italian study
title_short	Drug prescription appropriateness in the elderly: an Italian study
title_full	Drug prescription appropriateness in the elderly: an Italian study
title_fullStr	Drug prescription appropriateness in the elderly: an Italian study
title_full_unstemmed	Drug prescription appropriateness in the elderly: an Italian study
title_sort	drug prescription appropriateness in the elderly: an italian study
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/7d0ba00ee5bb4c5b81e7bf62de094134
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Drug prescription appropriateness in the elderly: an Italian study

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