Population-based serology reveals risk factors for RSV infection in children younger than 5 years

Abstract Respiratory syncytial virus (RSV) infection is a leading cause of hospitalization in infants. Underlying risk factors for RSV infection in the general population are not well understood, as previous work has focused on severe outcomes of infection in a clinical setting. Here we use RSV-spec...

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Autores principales:	Stijn P. Andeweg, Rutger M. Schepp, Jan van de Kassteele, Liesbeth Mollema, Guy A. M. Berbers, Michiel van Boven
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7d0c9712b01041a8bb3edf5fe6fbd3f1
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spelling	oai:doaj.org-article:7d0c9712b01041a8bb3edf5fe6fbd3f12021-12-02T16:55:24ZPopulation-based serology reveals risk factors for RSV infection in children younger than 5 years10.1038/s41598-021-88524-w2045-2322https://doaj.org/article/7d0c9712b01041a8bb3edf5fe6fbd3f12021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88524-whttps://doaj.org/toc/2045-2322Abstract Respiratory syncytial virus (RSV) infection is a leading cause of hospitalization in infants. Underlying risk factors for RSV infection in the general population are not well understood, as previous work has focused on severe outcomes of infection in a clinical setting. Here we use RSV-specific IgG and IgA antibody measurements from two population-based cross-sectional serosurveys carried out in the Netherlands (n = 682) to classify children up to 5 years as seronegative or seropositive. We employ a generalized additive model to estimate the probability of prior RSV infection as function of age, date of birth within the year, and other risk factors. The analyses show that the majority of children have experienced a RSV infection before the age of 2 years. Age and birthdate are strong predictors of RSV infection in the first years of life, and children born in summer have higher estimated probability of infection than those born in winter [e.g., 0.56 (95% CI 0.45–0.66) vs. 0.32 (0.21–0.45) at age 1 year]. Our analyses reveal that the mean age at infection depends on date of birth, which has implications for the design of vaccination programmes and prioritisation schemes for the prophylactic use of monoclonal antibodies.Stijn P. AndewegRutger M. ScheppJan van de KassteeleLiesbeth MollemaGuy A. M. BerbersMichiel van BovenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Stijn P. Andeweg Rutger M. Schepp Jan van de Kassteele Liesbeth Mollema Guy A. M. Berbers Michiel van Boven Population-based serology reveals risk factors for RSV infection in children younger than 5 years
description	Abstract Respiratory syncytial virus (RSV) infection is a leading cause of hospitalization in infants. Underlying risk factors for RSV infection in the general population are not well understood, as previous work has focused on severe outcomes of infection in a clinical setting. Here we use RSV-specific IgG and IgA antibody measurements from two population-based cross-sectional serosurveys carried out in the Netherlands (n = 682) to classify children up to 5 years as seronegative or seropositive. We employ a generalized additive model to estimate the probability of prior RSV infection as function of age, date of birth within the year, and other risk factors. The analyses show that the majority of children have experienced a RSV infection before the age of 2 years. Age and birthdate are strong predictors of RSV infection in the first years of life, and children born in summer have higher estimated probability of infection than those born in winter [e.g., 0.56 (95% CI 0.45–0.66) vs. 0.32 (0.21–0.45) at age 1 year]. Our analyses reveal that the mean age at infection depends on date of birth, which has implications for the design of vaccination programmes and prioritisation schemes for the prophylactic use of monoclonal antibodies.
format	article
author	Stijn P. Andeweg Rutger M. Schepp Jan van de Kassteele Liesbeth Mollema Guy A. M. Berbers Michiel van Boven
author_facet	Stijn P. Andeweg Rutger M. Schepp Jan van de Kassteele Liesbeth Mollema Guy A. M. Berbers Michiel van Boven
author_sort	Stijn P. Andeweg
title	Population-based serology reveals risk factors for RSV infection in children younger than 5 years
title_short	Population-based serology reveals risk factors for RSV infection in children younger than 5 years
title_full	Population-based serology reveals risk factors for RSV infection in children younger than 5 years
title_fullStr	Population-based serology reveals risk factors for RSV infection in children younger than 5 years
title_full_unstemmed	Population-based serology reveals risk factors for RSV infection in children younger than 5 years
title_sort	population-based serology reveals risk factors for rsv infection in children younger than 5 years
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7d0c9712b01041a8bb3edf5fe6fbd3f1
work_keys_str_mv	AT stijnpandeweg populationbasedserologyrevealsriskfactorsforrsvinfectioninchildrenyoungerthan5years AT rutgermschepp populationbasedserologyrevealsriskfactorsforrsvinfectioninchildrenyoungerthan5years AT janvandekassteele populationbasedserologyrevealsriskfactorsforrsvinfectioninchildrenyoungerthan5years AT liesbethmollema populationbasedserologyrevealsriskfactorsforrsvinfectioninchildrenyoungerthan5years AT guyamberbers populationbasedserologyrevealsriskfactorsforrsvinfectioninchildrenyoungerthan5years AT michielvanboven populationbasedserologyrevealsriskfactorsforrsvinfectioninchildrenyoungerthan5years
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Population-based serology reveals risk factors for RSV infection in children younger than 5 years

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