SIGNIFICANCE OF IMMUNOGENETIC PREDISPOSAL FOR CLINICAL COURSE OF MYASTHENIA

Abstract. The aim of this work was to reveal novel criteria for prediction of clinical course in myasthenia, based on immunogenetic characteristics of the patients. Sixty-five patients with different clinical forms, various clinical course and severity of myasthenia were involved into the study. All...

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Autores principales:	L. N. Bubnova, I. E. Pavlova, V. V. Baranov, N. M. Zhulev
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	myasthenia hla immunogenetic markers Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/7d0d47d14c0f466184b2a3735d0dbc52
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spelling	oai:doaj.org-article:7d0d47d14c0f466184b2a3735d0dbc522021-11-18T08:03:40ZSIGNIFICANCE OF IMMUNOGENETIC PREDISPOSAL FOR CLINICAL COURSE OF MYASTHENIA1563-06252313-741X10.15789/1563-0625-2009-6-549-556https://doaj.org/article/7d0d47d14c0f466184b2a3735d0dbc522014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/366https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. The aim of this work was to reveal novel criteria for prediction of clinical course in myasthenia, based on immunogenetic characteristics of the patients. Sixty-five patients with different clinical forms, various clinical course and severity of myasthenia were involved into the study. All the patients were subject to complete clinical and neurological examination, and all of them have undergone thymectomy, a histology of thymus has been performed. Immunogenetic studies included HLA class I typing (A and B loci), like as HLA class II typing (DRB* locus). A positive association was found between development of disorder and presence of HLAB8 antigen, HLA-DRB103, and their combination, thus allowing for suggesting these specificities as probable markers of genetic predisposition for myasthenia development. An HLA-B7 specificity may have a protective role in evolution of this disease. It was shown that clinical severity in myasthenia and degree of neuromuscular conductive disturbances were more expressed in the patients carrying HLA-B8 antigen and HLA-DRB103 allele. Evaluation of immunogenetic state at earlier stages of disorder allows of timely differential diagnostics and individual prediction of clinical variability in myasthenia patients.L. N. BubnovaI. E. PavlovaV. V. BaranovN. M. ZhulevSPb RAACIarticlemyastheniahlaimmunogenetic markersImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 11, Iss 6, Pp 549-556 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	myasthenia hla immunogenetic markers Immunologic diseases. Allergy RC581-607
spellingShingle	myasthenia hla immunogenetic markers Immunologic diseases. Allergy RC581-607 L. N. Bubnova I. E. Pavlova V. V. Baranov N. M. Zhulev SIGNIFICANCE OF IMMUNOGENETIC PREDISPOSAL FOR CLINICAL COURSE OF MYASTHENIA
description	Abstract. The aim of this work was to reveal novel criteria for prediction of clinical course in myasthenia, based on immunogenetic characteristics of the patients. Sixty-five patients with different clinical forms, various clinical course and severity of myasthenia were involved into the study. All the patients were subject to complete clinical and neurological examination, and all of them have undergone thymectomy, a histology of thymus has been performed. Immunogenetic studies included HLA class I typing (A and B loci), like as HLA class II typing (DRB* locus). A positive association was found between development of disorder and presence of HLAB8 antigen, HLA-DRB103, and their combination, thus allowing for suggesting these specificities as probable markers of genetic predisposition for myasthenia development. An HLA-B7 specificity may have a protective role in evolution of this disease. It was shown that clinical severity in myasthenia and degree of neuromuscular conductive disturbances were more expressed in the patients carrying HLA-B8 antigen and HLA-DRB103 allele. Evaluation of immunogenetic state at earlier stages of disorder allows of timely differential diagnostics and individual prediction of clinical variability in myasthenia patients.
format	article
author	L. N. Bubnova I. E. Pavlova V. V. Baranov N. M. Zhulev
author_facet	L. N. Bubnova I. E. Pavlova V. V. Baranov N. M. Zhulev
author_sort	L. N. Bubnova
title	SIGNIFICANCE OF IMMUNOGENETIC PREDISPOSAL FOR CLINICAL COURSE OF MYASTHENIA
title_short	SIGNIFICANCE OF IMMUNOGENETIC PREDISPOSAL FOR CLINICAL COURSE OF MYASTHENIA
title_full	SIGNIFICANCE OF IMMUNOGENETIC PREDISPOSAL FOR CLINICAL COURSE OF MYASTHENIA
title_fullStr	SIGNIFICANCE OF IMMUNOGENETIC PREDISPOSAL FOR CLINICAL COURSE OF MYASTHENIA
title_full_unstemmed	SIGNIFICANCE OF IMMUNOGENETIC PREDISPOSAL FOR CLINICAL COURSE OF MYASTHENIA
title_sort	significance of immunogenetic predisposal for clinical course of myasthenia
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/7d0d47d14c0f466184b2a3735d0dbc52
work_keys_str_mv	AT lnbubnova significanceofimmunogeneticpredisposalforclinicalcourseofmyasthenia AT iepavlova significanceofimmunogeneticpredisposalforclinicalcourseofmyasthenia AT vvbaranov significanceofimmunogeneticpredisposalforclinicalcourseofmyasthenia AT nmzhulev significanceofimmunogeneticpredisposalforclinicalcourseofmyasthenia
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SIGNIFICANCE OF IMMUNOGENETIC PREDISPOSAL FOR CLINICAL COURSE OF MYASTHENIA

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