CINNAMON EXTRACT PROVIDES MORE NEPHROPROTECTION THAN GREEN TEA IN BISPHENOL - A INDUCED DAMAGE IN PROXIMAL AND DISTAL KIDNEY TUBULES

Objective: To compare protective potential of cinnamon extract and green tea against Bisphenol A induced changes in tubular histology of rat kidney. Design of Study: Randomized controlled trial. Place and Duration of Study: Duration of study was six months and was conducted in Islamic Internat...

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Autores principales:	Huma Beenish, Rehana Rana, Shabana Ali
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2019
Materias:	bisphenol a cinnamomumzeylanicum oxidative stress Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/7d16d6e11dec4d8884985a77e4a1342e
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spelling	oai:doaj.org-article:7d16d6e11dec4d8884985a77e4a1342e2021-11-15T03:00:32ZCINNAMON EXTRACT PROVIDES MORE NEPHROPROTECTION THAN GREEN TEA IN BISPHENOL - A INDUCED DAMAGE IN PROXIMAL AND DISTAL KIDNEY TUBULES0030-96482411-8842https://doaj.org/article/7d16d6e11dec4d8884985a77e4a1342e2019-04-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/2767/2172https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To compare protective potential of cinnamon extract and green tea against Bisphenol A induced changes in tubular histology of rat kidney. Design of Study: Randomized controlled trial. Place and Duration of Study: Duration of study was six months and was conducted in Islamic International Medical College in collaboration with NIH. Material and Methods: Sixty adult male rats of Sprague Dawley strain were placed in 4 cages having 15 rats each. Experimental duration was 30 days. Rats in control group A were subcutaneously injected with distilled water. Rats in experimental group B were given subcutaneous injections of BPA at dose of 30mg/kg/day. Rats in group C were given cinnamon (200mg/kg/day) orally along with s/c injection of BPA while group D rats were given green tea orally along with s/c BPA injections. All rats were dissected after 30 days and right kidneys were taken out to examine histological changes in proximal and distal convoluted tubules. Results: Histological parameters of proximal and distal convoluted tubules were observed in experimental and control groups. Marked deterioration of tubular structure was observed in group B as compared to control group. Although both groups C and D showed nephroprotection against tubular histological changes but group D offered greater nephroprotection than group C. Conclusion: Green tea was more effective than cinnamon in combating the oxidative stress induced neprotoxicity caused by BPA. Co-administration of cinnamon and green tea with BPA reduced the histological damage in proximal and distal convoluted tubules of nephrons in rats caused by Bisphenol A.Huma BeenishRehana RanaShabana AliArmy Medical College Rawalpindiarticlebisphenol acinnamomumzeylanicumoxidative stressMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 69, Iss 2, Pp 424-428 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	bisphenol a cinnamomumzeylanicum oxidative stress Medicine R Medicine (General) R5-920
spellingShingle	bisphenol a cinnamomumzeylanicum oxidative stress Medicine R Medicine (General) R5-920 Huma Beenish Rehana Rana Shabana Ali CINNAMON EXTRACT PROVIDES MORE NEPHROPROTECTION THAN GREEN TEA IN BISPHENOL - A INDUCED DAMAGE IN PROXIMAL AND DISTAL KIDNEY TUBULES
description	Objective: To compare protective potential of cinnamon extract and green tea against Bisphenol A induced changes in tubular histology of rat kidney. Design of Study: Randomized controlled trial. Place and Duration of Study: Duration of study was six months and was conducted in Islamic International Medical College in collaboration with NIH. Material and Methods: Sixty adult male rats of Sprague Dawley strain were placed in 4 cages having 15 rats each. Experimental duration was 30 days. Rats in control group A were subcutaneously injected with distilled water. Rats in experimental group B were given subcutaneous injections of BPA at dose of 30mg/kg/day. Rats in group C were given cinnamon (200mg/kg/day) orally along with s/c injection of BPA while group D rats were given green tea orally along with s/c BPA injections. All rats were dissected after 30 days and right kidneys were taken out to examine histological changes in proximal and distal convoluted tubules. Results: Histological parameters of proximal and distal convoluted tubules were observed in experimental and control groups. Marked deterioration of tubular structure was observed in group B as compared to control group. Although both groups C and D showed nephroprotection against tubular histological changes but group D offered greater nephroprotection than group C. Conclusion: Green tea was more effective than cinnamon in combating the oxidative stress induced neprotoxicity caused by BPA. Co-administration of cinnamon and green tea with BPA reduced the histological damage in proximal and distal convoluted tubules of nephrons in rats caused by Bisphenol A.
format	article
author	Huma Beenish Rehana Rana Shabana Ali
author_facet	Huma Beenish Rehana Rana Shabana Ali
author_sort	Huma Beenish
title	CINNAMON EXTRACT PROVIDES MORE NEPHROPROTECTION THAN GREEN TEA IN BISPHENOL - A INDUCED DAMAGE IN PROXIMAL AND DISTAL KIDNEY TUBULES
title_short	CINNAMON EXTRACT PROVIDES MORE NEPHROPROTECTION THAN GREEN TEA IN BISPHENOL - A INDUCED DAMAGE IN PROXIMAL AND DISTAL KIDNEY TUBULES
title_full	CINNAMON EXTRACT PROVIDES MORE NEPHROPROTECTION THAN GREEN TEA IN BISPHENOL - A INDUCED DAMAGE IN PROXIMAL AND DISTAL KIDNEY TUBULES
title_fullStr	CINNAMON EXTRACT PROVIDES MORE NEPHROPROTECTION THAN GREEN TEA IN BISPHENOL - A INDUCED DAMAGE IN PROXIMAL AND DISTAL KIDNEY TUBULES
title_full_unstemmed	CINNAMON EXTRACT PROVIDES MORE NEPHROPROTECTION THAN GREEN TEA IN BISPHENOL - A INDUCED DAMAGE IN PROXIMAL AND DISTAL KIDNEY TUBULES
title_sort	cinnamon extract provides more nephroprotection than green tea in bisphenol - a induced damage in proximal and distal kidney tubules
publisher	Army Medical College Rawalpindi
publishDate	2019
url	https://doaj.org/article/7d16d6e11dec4d8884985a77e4a1342e
work_keys_str_mv	AT humabeenish cinnamonextractprovidesmorenephroprotectionthangreenteainbisphenolainduceddamageinproximalanddistalkidneytubules AT rehanarana cinnamonextractprovidesmorenephroprotectionthangreenteainbisphenolainduceddamageinproximalanddistalkidneytubules AT shabanaali cinnamonextractprovidesmorenephroprotectionthangreenteainbisphenolainduceddamageinproximalanddistalkidneytubules
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CINNAMON EXTRACT PROVIDES MORE NEPHROPROTECTION THAN GREEN TEA IN BISPHENOL - A INDUCED DAMAGE IN PROXIMAL AND DISTAL KIDNEY TUBULES

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