Trends in type 2 diabetes mellitus disease burden in European Union countries between 1990 and 2019

Abstract This observational study aimed to assess trends in type 2 diabetes mellitus (T2DM) disease burden in European Union countries for the years 1990–2019. Sex specific T2DM age-standardised prevalence (ASPRs), mortality (ASMRs) and disability-adjusted life-year rates (DALYs) per 100,000 populat...

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Autores principales:	Richard Goodall, Andrew Alazawi, Will Hughes, Vassiliki Bravis, Justin D. Salciccioli, Dominic C. Marshall, Conor Crowley, Joseph Shalhoub
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7d185353883d407e99a86a669a4c2966
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spelling	oai:doaj.org-article:7d185353883d407e99a86a669a4c29662021-12-02T16:31:02ZTrends in type 2 diabetes mellitus disease burden in European Union countries between 1990 and 201910.1038/s41598-021-94807-z2045-2322https://doaj.org/article/7d185353883d407e99a86a669a4c29662021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94807-zhttps://doaj.org/toc/2045-2322Abstract This observational study aimed to assess trends in type 2 diabetes mellitus (T2DM) disease burden in European Union countries for the years 1990–2019. Sex specific T2DM age-standardised prevalence (ASPRs), mortality (ASMRs) and disability-adjusted life-year rates (DALYs) per 100,000 population were extracted from the Global Burden of Disease (GBD) Study online results tool for each EU country (inclusive of the United Kingdom), for the years 1990–2019. Trends were analysed using Joinpoint regression analysis. Between 1990 and 2019, increases in T2DM ASPRs were observed for all EU countries. The highest relative increases in ASPRs were observed in Luxembourg (males + 269.1%, females + 219.2%), Ireland (males + 191.9%, females + 165.7%) and the UK (males + 128.6%, females + 114.6%). Mortality trends were less uniform across EU countries, however a general trend towards reducing T2DM mortality was observed, with ASMRs decreasing over the 30-year period studied in 16/28 countries for males and in 24/28 countries for females. The UK observed the highest relative decrease in ASMRs for males (− 46.9%). For females, the largest relative decrease in ASMRs was in Cyprus (− 67.6%). DALYs increased in 25/28 countries for males and in 17/28 countries for females between 1990 and 2019. DALYs were higher in males than females in all EU countries in 2019. T2DM prevalence rates have increased across EU countries over the last 30 years. Mortality from T2DM has generally decreased in EU countries, however trends were more variable than those observed for prevalence. Primary prevention strategies should continue to be a focus for preventing T2DM in at risk groups in EU countries.Richard GoodallAndrew AlazawiWill HughesVassiliki BravisJustin D. SalciccioliDominic C. MarshallConor CrowleyJoseph ShalhoubNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Richard Goodall Andrew Alazawi Will Hughes Vassiliki Bravis Justin D. Salciccioli Dominic C. Marshall Conor Crowley Joseph Shalhoub Trends in type 2 diabetes mellitus disease burden in European Union countries between 1990 and 2019
description	Abstract This observational study aimed to assess trends in type 2 diabetes mellitus (T2DM) disease burden in European Union countries for the years 1990–2019. Sex specific T2DM age-standardised prevalence (ASPRs), mortality (ASMRs) and disability-adjusted life-year rates (DALYs) per 100,000 population were extracted from the Global Burden of Disease (GBD) Study online results tool for each EU country (inclusive of the United Kingdom), for the years 1990–2019. Trends were analysed using Joinpoint regression analysis. Between 1990 and 2019, increases in T2DM ASPRs were observed for all EU countries. The highest relative increases in ASPRs were observed in Luxembourg (males + 269.1%, females + 219.2%), Ireland (males + 191.9%, females + 165.7%) and the UK (males + 128.6%, females + 114.6%). Mortality trends were less uniform across EU countries, however a general trend towards reducing T2DM mortality was observed, with ASMRs decreasing over the 30-year period studied in 16/28 countries for males and in 24/28 countries for females. The UK observed the highest relative decrease in ASMRs for males (− 46.9%). For females, the largest relative decrease in ASMRs was in Cyprus (− 67.6%). DALYs increased in 25/28 countries for males and in 17/28 countries for females between 1990 and 2019. DALYs were higher in males than females in all EU countries in 2019. T2DM prevalence rates have increased across EU countries over the last 30 years. Mortality from T2DM has generally decreased in EU countries, however trends were more variable than those observed for prevalence. Primary prevention strategies should continue to be a focus for preventing T2DM in at risk groups in EU countries.
format	article
author	Richard Goodall Andrew Alazawi Will Hughes Vassiliki Bravis Justin D. Salciccioli Dominic C. Marshall Conor Crowley Joseph Shalhoub
author_facet	Richard Goodall Andrew Alazawi Will Hughes Vassiliki Bravis Justin D. Salciccioli Dominic C. Marshall Conor Crowley Joseph Shalhoub
author_sort	Richard Goodall
title	Trends in type 2 diabetes mellitus disease burden in European Union countries between 1990 and 2019
title_short	Trends in type 2 diabetes mellitus disease burden in European Union countries between 1990 and 2019
title_full	Trends in type 2 diabetes mellitus disease burden in European Union countries between 1990 and 2019
title_fullStr	Trends in type 2 diabetes mellitus disease burden in European Union countries between 1990 and 2019
title_full_unstemmed	Trends in type 2 diabetes mellitus disease burden in European Union countries between 1990 and 2019
title_sort	trends in type 2 diabetes mellitus disease burden in european union countries between 1990 and 2019
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7d185353883d407e99a86a669a4c2966
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Trends in type 2 diabetes mellitus disease burden in European Union countries between 1990 and 2019

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