The netrin receptor UNC-40/DCC assembles a postsynaptic scaffold and sets the synaptic content of GABAA receptors

The netrin receptor UNC-40/DCC assembles a postsynaptic scaffold and sets the synaptic content of GABAA receptors

The netrin receptor UNC-40/DCC is required to recruit GABAAR at neuromuscular junctions in C. elegans. Here, the authors show that UNC-40/DCC assembles an intracellular synaptic scaffold, regulating the content of GABAAR and inhibitory neurotransmission.

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Autores principales: Xin Zhou, Marine Gueydan, Maelle Jospin, Tingting Ji, Aurore Valfort, Bérangère Pinan-Lucarré, Jean-Louis Bessereau
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/7d1978beeef44807a09ef637fddb90d3
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spelling oai:doaj.org-article:7d1978beeef44807a09ef637fddb90d32021-12-02T14:47:29ZThe netrin receptor UNC-40/DCC assembles a postsynaptic scaffold and sets the synaptic content of GABAA receptors10.1038/s41467-020-16473-52041-1723https://doaj.org/article/7d1978beeef44807a09ef637fddb90d32020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16473-5https://doaj.org/toc/2041-1723The netrin receptor UNC-40/DCC is required to recruit GABAAR at neuromuscular junctions in C. elegans. Here, the authors show that UNC-40/DCC assembles an intracellular synaptic scaffold, regulating the content of GABAAR and inhibitory neurotransmission.Xin ZhouMarine GueydanMaelle JospinTingting JiAurore ValfortBérangère Pinan-LucarréJean-Louis BessereauNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xin Zhou
Marine Gueydan
Maelle Jospin
Tingting Ji
Aurore Valfort
Bérangère Pinan-Lucarré
Jean-Louis Bessereau
The netrin receptor UNC-40/DCC assembles a postsynaptic scaffold and sets the synaptic content of GABAA receptors
description The netrin receptor UNC-40/DCC is required to recruit GABAAR at neuromuscular junctions in C. elegans. Here, the authors show that UNC-40/DCC assembles an intracellular synaptic scaffold, regulating the content of GABAAR and inhibitory neurotransmission.
format article
author Xin Zhou
Marine Gueydan
Maelle Jospin
Tingting Ji
Aurore Valfort
Bérangère Pinan-Lucarré
Jean-Louis Bessereau
author_facet Xin Zhou
Marine Gueydan
Maelle Jospin
Tingting Ji
Aurore Valfort
Bérangère Pinan-Lucarré
Jean-Louis Bessereau
author_sort Xin Zhou
title The netrin receptor UNC-40/DCC assembles a postsynaptic scaffold and sets the synaptic content of GABAA receptors
title_short The netrin receptor UNC-40/DCC assembles a postsynaptic scaffold and sets the synaptic content of GABAA receptors
title_full The netrin receptor UNC-40/DCC assembles a postsynaptic scaffold and sets the synaptic content of GABAA receptors
title_fullStr The netrin receptor UNC-40/DCC assembles a postsynaptic scaffold and sets the synaptic content of GABAA receptors
title_full_unstemmed The netrin receptor UNC-40/DCC assembles a postsynaptic scaffold and sets the synaptic content of GABAA receptors
title_sort netrin receptor unc-40/dcc assembles a postsynaptic scaffold and sets the synaptic content of gabaa receptors
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/7d1978beeef44807a09ef637fddb90d3
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