Combined serum levels of multiple proteins in tPA-BDNF pathway may aid the diagnosis of five mental disorders
Abstract Mental disorders are severe, disabling conditions with unknown etiology and are commonly misdiagnosed when clinical symptomology criteria are solely used. Our previous work indicated that combination of serum levels of multiple proteins in tissue plasminogen activator (tPA)-brain-derived ne...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2017
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/7d1ed4e81f454f1bb8810dcc66916274 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:7d1ed4e81f454f1bb8810dcc66916274 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:7d1ed4e81f454f1bb8810dcc669162742021-12-02T11:53:06ZCombined serum levels of multiple proteins in tPA-BDNF pathway may aid the diagnosis of five mental disorders10.1038/s41598-017-06832-62045-2322https://doaj.org/article/7d1ed4e81f454f1bb8810dcc669162742017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06832-6https://doaj.org/toc/2045-2322Abstract Mental disorders are severe, disabling conditions with unknown etiology and are commonly misdiagnosed when clinical symptomology criteria are solely used. Our previous work indicated that combination of serum levels of multiple proteins in tissue plasminogen activator (tPA)-brain-derived neurotrophic factor (BDNF) pathway improved accuracy of diagnosis of major depressive disorder (MDD). Here, we measured serum levels of tPA, plasminogen activator inhibitor-1 (PAI-1), BDNF, precursor-BDNF (proBDNF), tropomyosin-related kinase B (TrkB) and neurotrophin receptor p75 (p75NTR) in patients with paranoid schizophrenia (SZ, n = 34), MDD (n = 30), bipolar mania (BM, n = 30), bipolar depression (BD, n = 22), panic disorder (PD, n = 30), and healthy controls (HCs, n = 30) by Enzyme-linked immunosorbent assay kits. We used receiver operating characteristic (ROC) curve to analyze diagnostic potential of these proteins. We found, compared with HCs, that serum tPA and proBDNF were lower in SZ, BM and BD; TrkB was lower in SZ and BD; and p75NTR was declined in SZ and BM. ROC analysis showed that combined serum level of tPA, PAI-1, BDNF, proBDNF, TrkB and p75NTR was better than any single protein in accuracy of diagnosis and differentiation, suggesting that the combination of multiple serum proteins levels in tPA-BDNF pathway may have a potential for a diagnostic panel in mental disorders.Suzhen ChenHaitang JiangYang LiuZhenhua HouYingying YueYuqun ZhangFuying ZhaoZhi XuYinghui LiXiaodong MouLei LiTianyu WangJingjing ZhaoChongyang HanYuxiu SuiMing WangZhong YangYan LuYifeng ZhuJianhua LiXinhua ShenFei SunQingsong ChenHuanxin ChenYonggui YuanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Suzhen Chen Haitang Jiang Yang Liu Zhenhua Hou Yingying Yue Yuqun Zhang Fuying Zhao Zhi Xu Yinghui Li Xiaodong Mou Lei Li Tianyu Wang Jingjing Zhao Chongyang Han Yuxiu Sui Ming Wang Zhong Yang Yan Lu Yifeng Zhu Jianhua Li Xinhua Shen Fei Sun Qingsong Chen Huanxin Chen Yonggui Yuan Combined serum levels of multiple proteins in tPA-BDNF pathway may aid the diagnosis of five mental disorders |
| description |
Abstract Mental disorders are severe, disabling conditions with unknown etiology and are commonly misdiagnosed when clinical symptomology criteria are solely used. Our previous work indicated that combination of serum levels of multiple proteins in tissue plasminogen activator (tPA)-brain-derived neurotrophic factor (BDNF) pathway improved accuracy of diagnosis of major depressive disorder (MDD). Here, we measured serum levels of tPA, plasminogen activator inhibitor-1 (PAI-1), BDNF, precursor-BDNF (proBDNF), tropomyosin-related kinase B (TrkB) and neurotrophin receptor p75 (p75NTR) in patients with paranoid schizophrenia (SZ, n = 34), MDD (n = 30), bipolar mania (BM, n = 30), bipolar depression (BD, n = 22), panic disorder (PD, n = 30), and healthy controls (HCs, n = 30) by Enzyme-linked immunosorbent assay kits. We used receiver operating characteristic (ROC) curve to analyze diagnostic potential of these proteins. We found, compared with HCs, that serum tPA and proBDNF were lower in SZ, BM and BD; TrkB was lower in SZ and BD; and p75NTR was declined in SZ and BM. ROC analysis showed that combined serum level of tPA, PAI-1, BDNF, proBDNF, TrkB and p75NTR was better than any single protein in accuracy of diagnosis and differentiation, suggesting that the combination of multiple serum proteins levels in tPA-BDNF pathway may have a potential for a diagnostic panel in mental disorders. |
| format |
article |
| author |
Suzhen Chen Haitang Jiang Yang Liu Zhenhua Hou Yingying Yue Yuqun Zhang Fuying Zhao Zhi Xu Yinghui Li Xiaodong Mou Lei Li Tianyu Wang Jingjing Zhao Chongyang Han Yuxiu Sui Ming Wang Zhong Yang Yan Lu Yifeng Zhu Jianhua Li Xinhua Shen Fei Sun Qingsong Chen Huanxin Chen Yonggui Yuan |
| author_facet |
Suzhen Chen Haitang Jiang Yang Liu Zhenhua Hou Yingying Yue Yuqun Zhang Fuying Zhao Zhi Xu Yinghui Li Xiaodong Mou Lei Li Tianyu Wang Jingjing Zhao Chongyang Han Yuxiu Sui Ming Wang Zhong Yang Yan Lu Yifeng Zhu Jianhua Li Xinhua Shen Fei Sun Qingsong Chen Huanxin Chen Yonggui Yuan |
| author_sort |
Suzhen Chen |
| title |
Combined serum levels of multiple proteins in tPA-BDNF pathway may aid the diagnosis of five mental disorders |
| title_short |
Combined serum levels of multiple proteins in tPA-BDNF pathway may aid the diagnosis of five mental disorders |
| title_full |
Combined serum levels of multiple proteins in tPA-BDNF pathway may aid the diagnosis of five mental disorders |
| title_fullStr |
Combined serum levels of multiple proteins in tPA-BDNF pathway may aid the diagnosis of five mental disorders |
| title_full_unstemmed |
Combined serum levels of multiple proteins in tPA-BDNF pathway may aid the diagnosis of five mental disorders |
| title_sort |
combined serum levels of multiple proteins in tpa-bdnf pathway may aid the diagnosis of five mental disorders |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/7d1ed4e81f454f1bb8810dcc66916274 |
| work_keys_str_mv |
AT suzhenchen combinedserumlevelsofmultipleproteinsintpabdnfpathwaymayaidthediagnosisoffivementaldisorders AT haitangjiang combinedserumlevelsofmultipleproteinsintpabdnfpathwaymayaidthediagnosisoffivementaldisorders AT yangliu combinedserumlevelsofmultipleproteinsintpabdnfpathwaymayaidthediagnosisoffivementaldisorders AT zhenhuahou combinedserumlevelsofmultipleproteinsintpabdnfpathwaymayaidthediagnosisoffivementaldisorders AT yingyingyue combinedserumlevelsofmultipleproteinsintpabdnfpathwaymayaidthediagnosisoffivementaldisorders AT yuqunzhang combinedserumlevelsofmultipleproteinsintpabdnfpathwaymayaidthediagnosisoffivementaldisorders AT fuyingzhao combinedserumlevelsofmultipleproteinsintpabdnfpathwaymayaidthediagnosisoffivementaldisorders AT zhixu combinedserumlevelsofmultipleproteinsintpabdnfpathwaymayaidthediagnosisoffivementaldisorders AT yinghuili combinedserumlevelsofmultipleproteinsintpabdnfpathwaymayaidthediagnosisoffivementaldisorders AT xiaodongmou combinedserumlevelsofmultipleproteinsintpabdnfpathwaymayaidthediagnosisoffivementaldisorders AT leili combinedserumlevelsofmultipleproteinsintpabdnfpathwaymayaidthediagnosisoffivementaldisorders AT tianyuwang combinedserumlevelsofmultipleproteinsintpabdnfpathwaymayaidthediagnosisoffivementaldisorders AT jingjingzhao combinedserumlevelsofmultipleproteinsintpabdnfpathwaymayaidthediagnosisoffivementaldisorders AT chongyanghan combinedserumlevelsofmultipleproteinsintpabdnfpathwaymayaidthediagnosisoffivementaldisorders AT yuxiusui combinedserumlevelsofmultipleproteinsintpabdnfpathwaymayaidthediagnosisoffivementaldisorders AT mingwang combinedserumlevelsofmultipleproteinsintpabdnfpathwaymayaidthediagnosisoffivementaldisorders AT zhongyang combinedserumlevelsofmultipleproteinsintpabdnfpathwaymayaidthediagnosisoffivementaldisorders AT yanlu combinedserumlevelsofmultipleproteinsintpabdnfpathwaymayaidthediagnosisoffivementaldisorders AT yifengzhu combinedserumlevelsofmultipleproteinsintpabdnfpathwaymayaidthediagnosisoffivementaldisorders AT jianhuali combinedserumlevelsofmultipleproteinsintpabdnfpathwaymayaidthediagnosisoffivementaldisorders AT xinhuashen combinedserumlevelsofmultipleproteinsintpabdnfpathwaymayaidthediagnosisoffivementaldisorders AT feisun combinedserumlevelsofmultipleproteinsintpabdnfpathwaymayaidthediagnosisoffivementaldisorders AT qingsongchen combinedserumlevelsofmultipleproteinsintpabdnfpathwaymayaidthediagnosisoffivementaldisorders AT huanxinchen combinedserumlevelsofmultipleproteinsintpabdnfpathwaymayaidthediagnosisoffivementaldisorders AT yongguiyuan combinedserumlevelsofmultipleproteinsintpabdnfpathwaymayaidthediagnosisoffivementaldisorders |
| _version_ |
1718394874825277440 |