RECEPTOR SUPERFAMILY OF TUMOR NECROSIS FACTOR Α, AND HSP90 HEAT SHOCK PROTEIN: A MOLECULAR BASIS FOR INTERACTIONS

Abstract. A study was performed aiming to investigate interactions between TNFα receptor (TNF1) superfamily and heat shock protein Hsp90, using a Jurkat tumor cell line. The tumor cells cultured in presence of Hsp90 inhibitor (17-AAG) showed increased numbers of cells, presenting surface...

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Autores principales:	N. V. Ryazantseva, E. V. Kaygorodova, M. V. Belkina, A. N. Maroshkina, O. E. Chechina, A. P. Zima, V. V. Novitskii
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	apoptosis hsp90 tnf fas Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/7d1f845ed3ab4ca1895b9e609f9f5a84
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spelling	oai:doaj.org-article:7d1f845ed3ab4ca1895b9e609f9f5a842021-11-18T08:03:42ZRECEPTOR SUPERFAMILY OF TUMOR NECROSIS FACTOR Α, AND HSP90 HEAT SHOCK PROTEIN: A MOLECULAR BASIS FOR INTERACTIONS1563-06252313-741X10.15789/1563-0625-2011-2-3-247-252https://doaj.org/article/7d1f845ed3ab4ca1895b9e609f9f5a842014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/517https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. A study was performed aiming to investigate interactions between TNFα receptor (TNF1) superfamily and heat shock protein Hsp90, using a Jurkat tumor cell line. The tumor cells cultured in presence of Hsp90 inhibitor (17-AAG) showed increased numbers of cells, presenting surface TNFR1 and FasR, which facilitate triggering of programmed cell death. It was also revealed that Hsp90 blockage under the in vitro conditions causes a decrease in FasL, while not affecting TNFα and sTNFR1 production by the tumor cells. (Med. Immunol., 2011, vol. 13, N 2-3, pp 247-252)N. V. RyazantsevaE. V. KaygorodovaM. V. BelkinaA. N. MaroshkinaO. E. ChechinaA. P. ZimaV. V. NovitskiiSPb RAACIarticleapoptosishsp90tnffasImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 13, Iss 2-3, Pp 247-252 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	apoptosis hsp90 tnf fas Immunologic diseases. Allergy RC581-607
spellingShingle	apoptosis hsp90 tnf fas Immunologic diseases. Allergy RC581-607 N. V. Ryazantseva E. V. Kaygorodova M. V. Belkina A. N. Maroshkina O. E. Chechina A. P. Zima V. V. Novitskii RECEPTOR SUPERFAMILY OF TUMOR NECROSIS FACTOR Α, AND HSP90 HEAT SHOCK PROTEIN: A MOLECULAR BASIS FOR INTERACTIONS
description	Abstract. A study was performed aiming to investigate interactions between TNFα receptor (TNF1) superfamily and heat shock protein Hsp90, using a Jurkat tumor cell line. The tumor cells cultured in presence of Hsp90 inhibitor (17-AAG) showed increased numbers of cells, presenting surface TNFR1 and FasR, which facilitate triggering of programmed cell death. It was also revealed that Hsp90 blockage under the in vitro conditions causes a decrease in FasL, while not affecting TNFα and sTNFR1 production by the tumor cells. (Med. Immunol., 2011, vol. 13, N 2-3, pp 247-252)
format	article
author	N. V. Ryazantseva E. V. Kaygorodova M. V. Belkina A. N. Maroshkina O. E. Chechina A. P. Zima V. V. Novitskii
author_facet	N. V. Ryazantseva E. V. Kaygorodova M. V. Belkina A. N. Maroshkina O. E. Chechina A. P. Zima V. V. Novitskii
author_sort	N. V. Ryazantseva
title	RECEPTOR SUPERFAMILY OF TUMOR NECROSIS FACTOR Α, AND HSP90 HEAT SHOCK PROTEIN: A MOLECULAR BASIS FOR INTERACTIONS
title_short	RECEPTOR SUPERFAMILY OF TUMOR NECROSIS FACTOR Α, AND HSP90 HEAT SHOCK PROTEIN: A MOLECULAR BASIS FOR INTERACTIONS
title_full	RECEPTOR SUPERFAMILY OF TUMOR NECROSIS FACTOR Α, AND HSP90 HEAT SHOCK PROTEIN: A MOLECULAR BASIS FOR INTERACTIONS
title_fullStr	RECEPTOR SUPERFAMILY OF TUMOR NECROSIS FACTOR Α, AND HSP90 HEAT SHOCK PROTEIN: A MOLECULAR BASIS FOR INTERACTIONS
title_full_unstemmed	RECEPTOR SUPERFAMILY OF TUMOR NECROSIS FACTOR Α, AND HSP90 HEAT SHOCK PROTEIN: A MOLECULAR BASIS FOR INTERACTIONS
title_sort	receptor superfamily of tumor necrosis factor α, and hsp90 heat shock protein: a molecular basis for interactions
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/7d1f845ed3ab4ca1895b9e609f9f5a84
work_keys_str_mv	AT nvryazantseva receptorsuperfamilyoftumornecrosisfactoraandhsp90heatshockproteinamolecularbasisforinteractions AT evkaygorodova receptorsuperfamilyoftumornecrosisfactoraandhsp90heatshockproteinamolecularbasisforinteractions AT mvbelkina receptorsuperfamilyoftumornecrosisfactoraandhsp90heatshockproteinamolecularbasisforinteractions AT anmaroshkina receptorsuperfamilyoftumornecrosisfactoraandhsp90heatshockproteinamolecularbasisforinteractions AT oechechina receptorsuperfamilyoftumornecrosisfactoraandhsp90heatshockproteinamolecularbasisforinteractions AT apzima receptorsuperfamilyoftumornecrosisfactoraandhsp90heatshockproteinamolecularbasisforinteractions AT vvnovitskii receptorsuperfamilyoftumornecrosisfactoraandhsp90heatshockproteinamolecularbasisforinteractions
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RECEPTOR SUPERFAMILY OF TUMOR NECROSIS FACTOR Α, AND HSP90 HEAT SHOCK PROTEIN: A MOLECULAR BASIS FOR INTERACTIONS

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