Do Anxiety and Depression Predict Persistent Physical Symptoms After a Severe COVID-19 Episode? A Prospective Study
Background: Persistent physical symptoms are common after a coronavirus disease 2019 (COVID-19) episode, but their pathophysiological mechanisms remain poorly understood. In this study, we aimed to explore the association between anxiety and depression at 1-month after acute infection and the presen...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:7d2059c135354b63a857f45ac9a3c9eb2021-11-10T07:49:36ZDo Anxiety and Depression Predict Persistent Physical Symptoms After a Severe COVID-19 Episode? A Prospective Study1664-064010.3389/fpsyt.2021.757685https://doaj.org/article/7d2059c135354b63a857f45ac9a3c9eb2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fpsyt.2021.757685/fullhttps://doaj.org/toc/1664-0640Background: Persistent physical symptoms are common after a coronavirus disease 2019 (COVID-19) episode, but their pathophysiological mechanisms remain poorly understood. In this study, we aimed to explore the association between anxiety and depression at 1-month after acute infection and the presence of fatigue, dyspnea, and pain complaints at 3-month follow-up.Methods: We conducted a prospective study in patients previously hospitalized for COVID-19 followed up for 3 months. The Hospital Anxiety and Depression Scale (HAD-S) was administered by physicians at 1-month follow-up, and the presence of fatigue, dyspnea, and pain complaints was assessed at both 1 month and 3 months. Multivariable logistic regressions explored the association between anxiety and depression subscores and the persistence of each of the physical symptom at 3 months.Results: A total of 84 patients were included in this study (Median age: 60 years, interquartile range: 50.5–67.5 years, 23 women). We did not find any significant interaction between anxiety and the presence of fatigue, dyspnea, or pain complaints at 1 month in predicting the persistence of these symptoms at 3 months (all p ≥ 0.36). In contrast, depression significantly interacted with the presence of pain at 1 month in predicting the persistence of pain at 3 months (OR: 1.60, 95% CI: 1.02–2.51, p = 0.039), with a similar trend for dyspnea (OR: 1.51, 95% CI: 0.99–2.28, p = 0.052).Discussion and Conclusion: Contrary to anxiety, depression after an acute COVID-19 episode may be associated with and increased risk of some persistent physical symptoms, including pain and dyspnea.Hugo BottemanneClément GouraudJean-Sébastien HulotAnne BlanchardBrigitte RanqueKhadija Lahlou-LaforêtFrédéric LimosinSven GüntherSven GüntherDavid LebeauxCédric LemogneCédric LemogneFrontiers Media S.A.articleanxietyCOVID-19long Covidpost-covid conditionpost-acute COVID-19 syndromesomatoform disordersPsychiatryRC435-571ENFrontiers in Psychiatry, Vol 12 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
anxiety COVID-19 long Covid post-covid condition post-acute COVID-19 syndrome somatoform disorders Psychiatry RC435-571 |
| spellingShingle |
anxiety COVID-19 long Covid post-covid condition post-acute COVID-19 syndrome somatoform disorders Psychiatry RC435-571 Hugo Bottemanne Clément Gouraud Jean-Sébastien Hulot Anne Blanchard Brigitte Ranque Khadija Lahlou-Laforêt Frédéric Limosin Sven Günther Sven Günther David Lebeaux Cédric Lemogne Cédric Lemogne Do Anxiety and Depression Predict Persistent Physical Symptoms After a Severe COVID-19 Episode? A Prospective Study |
| description |
Background: Persistent physical symptoms are common after a coronavirus disease 2019 (COVID-19) episode, but their pathophysiological mechanisms remain poorly understood. In this study, we aimed to explore the association between anxiety and depression at 1-month after acute infection and the presence of fatigue, dyspnea, and pain complaints at 3-month follow-up.Methods: We conducted a prospective study in patients previously hospitalized for COVID-19 followed up for 3 months. The Hospital Anxiety and Depression Scale (HAD-S) was administered by physicians at 1-month follow-up, and the presence of fatigue, dyspnea, and pain complaints was assessed at both 1 month and 3 months. Multivariable logistic regressions explored the association between anxiety and depression subscores and the persistence of each of the physical symptom at 3 months.Results: A total of 84 patients were included in this study (Median age: 60 years, interquartile range: 50.5–67.5 years, 23 women). We did not find any significant interaction between anxiety and the presence of fatigue, dyspnea, or pain complaints at 1 month in predicting the persistence of these symptoms at 3 months (all p ≥ 0.36). In contrast, depression significantly interacted with the presence of pain at 1 month in predicting the persistence of pain at 3 months (OR: 1.60, 95% CI: 1.02–2.51, p = 0.039), with a similar trend for dyspnea (OR: 1.51, 95% CI: 0.99–2.28, p = 0.052).Discussion and Conclusion: Contrary to anxiety, depression after an acute COVID-19 episode may be associated with and increased risk of some persistent physical symptoms, including pain and dyspnea. |
| format |
article |
| author |
Hugo Bottemanne Clément Gouraud Jean-Sébastien Hulot Anne Blanchard Brigitte Ranque Khadija Lahlou-Laforêt Frédéric Limosin Sven Günther Sven Günther David Lebeaux Cédric Lemogne Cédric Lemogne |
| author_facet |
Hugo Bottemanne Clément Gouraud Jean-Sébastien Hulot Anne Blanchard Brigitte Ranque Khadija Lahlou-Laforêt Frédéric Limosin Sven Günther Sven Günther David Lebeaux Cédric Lemogne Cédric Lemogne |
| author_sort |
Hugo Bottemanne |
| title |
Do Anxiety and Depression Predict Persistent Physical Symptoms After a Severe COVID-19 Episode? A Prospective Study |
| title_short |
Do Anxiety and Depression Predict Persistent Physical Symptoms After a Severe COVID-19 Episode? A Prospective Study |
| title_full |
Do Anxiety and Depression Predict Persistent Physical Symptoms After a Severe COVID-19 Episode? A Prospective Study |
| title_fullStr |
Do Anxiety and Depression Predict Persistent Physical Symptoms After a Severe COVID-19 Episode? A Prospective Study |
| title_full_unstemmed |
Do Anxiety and Depression Predict Persistent Physical Symptoms After a Severe COVID-19 Episode? A Prospective Study |
| title_sort |
do anxiety and depression predict persistent physical symptoms after a severe covid-19 episode? a prospective study |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/7d2059c135354b63a857f45ac9a3c9eb |
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