Quality of life and therapeutic regimen management in onychomycosis patients and in vitro study of antiseptic solutions

Abstract Onychomycosis or tinea unguium (EE12.1) and Onychomycosis due to non-dermatophyte moulds (1F2D.5) (OM) is a fungal infection of the nail plates with a high prevalence that often affects vulnerable people with co-existing health problems. Gold standard pharmacological treatments for onychomy...

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Autores principales:	Vasco Silva-Neves, Vitor Hugo, Paulo Alves, João Costa Amado, Carla Pais-Vieira, Fátima Sousa, Fátima Cerqueira, Eugénia Pinto, Miguel Pais-Vieira
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7d21d3faad0141b6b72a94b4ee6d74c1
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spelling	oai:doaj.org-article:7d21d3faad0141b6b72a94b4ee6d74c12021-12-02T17:40:06ZQuality of life and therapeutic regimen management in onychomycosis patients and in vitro study of antiseptic solutions10.1038/s41598-021-92111-42045-2322https://doaj.org/article/7d21d3faad0141b6b72a94b4ee6d74c12021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92111-4https://doaj.org/toc/2045-2322Abstract Onychomycosis or tinea unguium (EE12.1) and Onychomycosis due to non-dermatophyte moulds (1F2D.5) (OM) is a fungal infection of the nail plates with a high prevalence that often affects vulnerable people with co-existing health problems. Gold standard pharmacological treatments for onychomycosis have been associated with low success rates and increasing antifungal resistance, suggesting that treatment outcome is dependent on multiple variables. Here, the prevalence of OM and quality of life were characterized in two vulnerable populations—Hospital patients and Homeless people. Comparing both groups, the most prevalent fungal species were identified in Hospital patients. Then, the in vitro fungicidal properties of the antiseptics povidone-iodine, polyhexamethylene biguanide-betaine, octenidine dihydrochloride, and a super-oxidized solution against two ATCC strains (Candida albicans and Aspergillus niger) and three clinical fungal isolates from Hospital patients (Candida parapsilosis, Trichophyton interdigitale, and Trichophyton rubrum) were tested. OM prevalence was high in both patient groups studied, who also reported a reduction in quality of life and concerns about the state of their feet. In addition, Hospital patients had a non-negligent therapeutic regimen management style. Antiseptics tested in vitro revealed antifungal properties. As antiseptics are low-cost and easy to apply and have few iatrogenic effects, the demonstration of fungicidal properties of these solutions suggests that they may constitute potential supportive therapeutics for OM.Vasco Silva-NevesVitor HugoPaulo AlvesJoão Costa AmadoCarla Pais-VieiraFátima SousaFátima CerqueiraEugénia PintoMiguel Pais-VieiraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Vasco Silva-Neves Vitor Hugo Paulo Alves João Costa Amado Carla Pais-Vieira Fátima Sousa Fátima Cerqueira Eugénia Pinto Miguel Pais-Vieira Quality of life and therapeutic regimen management in onychomycosis patients and in vitro study of antiseptic solutions
description	Abstract Onychomycosis or tinea unguium (EE12.1) and Onychomycosis due to non-dermatophyte moulds (1F2D.5) (OM) is a fungal infection of the nail plates with a high prevalence that often affects vulnerable people with co-existing health problems. Gold standard pharmacological treatments for onychomycosis have been associated with low success rates and increasing antifungal resistance, suggesting that treatment outcome is dependent on multiple variables. Here, the prevalence of OM and quality of life were characterized in two vulnerable populations—Hospital patients and Homeless people. Comparing both groups, the most prevalent fungal species were identified in Hospital patients. Then, the in vitro fungicidal properties of the antiseptics povidone-iodine, polyhexamethylene biguanide-betaine, octenidine dihydrochloride, and a super-oxidized solution against two ATCC strains (Candida albicans and Aspergillus niger) and three clinical fungal isolates from Hospital patients (Candida parapsilosis, Trichophyton interdigitale, and Trichophyton rubrum) were tested. OM prevalence was high in both patient groups studied, who also reported a reduction in quality of life and concerns about the state of their feet. In addition, Hospital patients had a non-negligent therapeutic regimen management style. Antiseptics tested in vitro revealed antifungal properties. As antiseptics are low-cost and easy to apply and have few iatrogenic effects, the demonstration of fungicidal properties of these solutions suggests that they may constitute potential supportive therapeutics for OM.
format	article
author	Vasco Silva-Neves Vitor Hugo Paulo Alves João Costa Amado Carla Pais-Vieira Fátima Sousa Fátima Cerqueira Eugénia Pinto Miguel Pais-Vieira
author_facet	Vasco Silva-Neves Vitor Hugo Paulo Alves João Costa Amado Carla Pais-Vieira Fátima Sousa Fátima Cerqueira Eugénia Pinto Miguel Pais-Vieira
author_sort	Vasco Silva-Neves
title	Quality of life and therapeutic regimen management in onychomycosis patients and in vitro study of antiseptic solutions
title_short	Quality of life and therapeutic regimen management in onychomycosis patients and in vitro study of antiseptic solutions
title_full	Quality of life and therapeutic regimen management in onychomycosis patients and in vitro study of antiseptic solutions
title_fullStr	Quality of life and therapeutic regimen management in onychomycosis patients and in vitro study of antiseptic solutions
title_full_unstemmed	Quality of life and therapeutic regimen management in onychomycosis patients and in vitro study of antiseptic solutions
title_sort	quality of life and therapeutic regimen management in onychomycosis patients and in vitro study of antiseptic solutions
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7d21d3faad0141b6b72a94b4ee6d74c1
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Quality of life and therapeutic regimen management in onychomycosis patients and in vitro study of antiseptic solutions

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