Quality of life and therapeutic regimen management in onychomycosis patients and in vitro study of antiseptic solutions
Abstract Onychomycosis or tinea unguium (EE12.1) and Onychomycosis due to non-dermatophyte moulds (1F2D.5) (OM) is a fungal infection of the nail plates with a high prevalence that often affects vulnerable people with co-existing health problems. Gold standard pharmacological treatments for onychomy...
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Nature Portfolio
2021
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oai:doaj.org-article:7d21d3faad0141b6b72a94b4ee6d74c12021-12-02T17:40:06ZQuality of life and therapeutic regimen management in onychomycosis patients and in vitro study of antiseptic solutions10.1038/s41598-021-92111-42045-2322https://doaj.org/article/7d21d3faad0141b6b72a94b4ee6d74c12021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92111-4https://doaj.org/toc/2045-2322Abstract Onychomycosis or tinea unguium (EE12.1) and Onychomycosis due to non-dermatophyte moulds (1F2D.5) (OM) is a fungal infection of the nail plates with a high prevalence that often affects vulnerable people with co-existing health problems. Gold standard pharmacological treatments for onychomycosis have been associated with low success rates and increasing antifungal resistance, suggesting that treatment outcome is dependent on multiple variables. Here, the prevalence of OM and quality of life were characterized in two vulnerable populations—Hospital patients and Homeless people. Comparing both groups, the most prevalent fungal species were identified in Hospital patients. Then, the in vitro fungicidal properties of the antiseptics povidone-iodine, polyhexamethylene biguanide-betaine, octenidine dihydrochloride, and a super-oxidized solution against two ATCC strains (Candida albicans and Aspergillus niger) and three clinical fungal isolates from Hospital patients (Candida parapsilosis, Trichophyton interdigitale, and Trichophyton rubrum) were tested. OM prevalence was high in both patient groups studied, who also reported a reduction in quality of life and concerns about the state of their feet. In addition, Hospital patients had a non-negligent therapeutic regimen management style. Antiseptics tested in vitro revealed antifungal properties. As antiseptics are low-cost and easy to apply and have few iatrogenic effects, the demonstration of fungicidal properties of these solutions suggests that they may constitute potential supportive therapeutics for OM.Vasco Silva-NevesVitor HugoPaulo AlvesJoão Costa AmadoCarla Pais-VieiraFátima SousaFátima CerqueiraEugénia PintoMiguel Pais-VieiraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) |
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Medicine R Science Q Vasco Silva-Neves Vitor Hugo Paulo Alves João Costa Amado Carla Pais-Vieira Fátima Sousa Fátima Cerqueira Eugénia Pinto Miguel Pais-Vieira Quality of life and therapeutic regimen management in onychomycosis patients and in vitro study of antiseptic solutions |
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Abstract Onychomycosis or tinea unguium (EE12.1) and Onychomycosis due to non-dermatophyte moulds (1F2D.5) (OM) is a fungal infection of the nail plates with a high prevalence that often affects vulnerable people with co-existing health problems. Gold standard pharmacological treatments for onychomycosis have been associated with low success rates and increasing antifungal resistance, suggesting that treatment outcome is dependent on multiple variables. Here, the prevalence of OM and quality of life were characterized in two vulnerable populations—Hospital patients and Homeless people. Comparing both groups, the most prevalent fungal species were identified in Hospital patients. Then, the in vitro fungicidal properties of the antiseptics povidone-iodine, polyhexamethylene biguanide-betaine, octenidine dihydrochloride, and a super-oxidized solution against two ATCC strains (Candida albicans and Aspergillus niger) and three clinical fungal isolates from Hospital patients (Candida parapsilosis, Trichophyton interdigitale, and Trichophyton rubrum) were tested. OM prevalence was high in both patient groups studied, who also reported a reduction in quality of life and concerns about the state of their feet. In addition, Hospital patients had a non-negligent therapeutic regimen management style. Antiseptics tested in vitro revealed antifungal properties. As antiseptics are low-cost and easy to apply and have few iatrogenic effects, the demonstration of fungicidal properties of these solutions suggests that they may constitute potential supportive therapeutics for OM. |
format |
article |
author |
Vasco Silva-Neves Vitor Hugo Paulo Alves João Costa Amado Carla Pais-Vieira Fátima Sousa Fátima Cerqueira Eugénia Pinto Miguel Pais-Vieira |
author_facet |
Vasco Silva-Neves Vitor Hugo Paulo Alves João Costa Amado Carla Pais-Vieira Fátima Sousa Fátima Cerqueira Eugénia Pinto Miguel Pais-Vieira |
author_sort |
Vasco Silva-Neves |
title |
Quality of life and therapeutic regimen management in onychomycosis patients and in vitro study of antiseptic solutions |
title_short |
Quality of life and therapeutic regimen management in onychomycosis patients and in vitro study of antiseptic solutions |
title_full |
Quality of life and therapeutic regimen management in onychomycosis patients and in vitro study of antiseptic solutions |
title_fullStr |
Quality of life and therapeutic regimen management in onychomycosis patients and in vitro study of antiseptic solutions |
title_full_unstemmed |
Quality of life and therapeutic regimen management in onychomycosis patients and in vitro study of antiseptic solutions |
title_sort |
quality of life and therapeutic regimen management in onychomycosis patients and in vitro study of antiseptic solutions |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/7d21d3faad0141b6b72a94b4ee6d74c1 |
work_keys_str_mv |
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