Quality of life and therapeutic regimen management in onychomycosis patients and in vitro study of antiseptic solutions

Abstract Onychomycosis or tinea unguium (EE12.1) and Onychomycosis due to non-dermatophyte moulds (1F2D.5) (OM) is a fungal infection of the nail plates with a high prevalence that often affects vulnerable people with co-existing health problems. Gold standard pharmacological treatments for onychomy...

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Autores principales: Vasco Silva-Neves, Vitor Hugo, Paulo Alves, João Costa Amado, Carla Pais-Vieira, Fátima Sousa, Fátima Cerqueira, Eugénia Pinto, Miguel Pais-Vieira
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Publicado: Nature Portfolio 2021
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spelling oai:doaj.org-article:7d21d3faad0141b6b72a94b4ee6d74c12021-12-02T17:40:06ZQuality of life and therapeutic regimen management in onychomycosis patients and in vitro study of antiseptic solutions10.1038/s41598-021-92111-42045-2322https://doaj.org/article/7d21d3faad0141b6b72a94b4ee6d74c12021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92111-4https://doaj.org/toc/2045-2322Abstract Onychomycosis or tinea unguium (EE12.1) and Onychomycosis due to non-dermatophyte moulds (1F2D.5) (OM) is a fungal infection of the nail plates with a high prevalence that often affects vulnerable people with co-existing health problems. Gold standard pharmacological treatments for onychomycosis have been associated with low success rates and increasing antifungal resistance, suggesting that treatment outcome is dependent on multiple variables. Here, the prevalence of OM and quality of life were characterized in two vulnerable populations—Hospital patients and Homeless people. Comparing both groups, the most prevalent fungal species were identified in Hospital patients. Then, the in vitro fungicidal properties of the antiseptics povidone-iodine, polyhexamethylene biguanide-betaine, octenidine dihydrochloride, and a super-oxidized solution against two ATCC strains (Candida albicans and Aspergillus niger) and three clinical fungal isolates from Hospital patients (Candida parapsilosis, Trichophyton interdigitale, and Trichophyton rubrum) were tested. OM prevalence was high in both patient groups studied, who also reported a reduction in quality of life and concerns about the state of their feet. In addition, Hospital patients had a non-negligent therapeutic regimen management style. Antiseptics tested in vitro revealed antifungal properties. As antiseptics are low-cost and easy to apply and have few iatrogenic effects, the demonstration of fungicidal properties of these solutions suggests that they may constitute potential supportive therapeutics for OM.Vasco Silva-NevesVitor HugoPaulo AlvesJoão Costa AmadoCarla Pais-VieiraFátima SousaFátima CerqueiraEugénia PintoMiguel Pais-VieiraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Vasco Silva-Neves
Vitor Hugo
Paulo Alves
João Costa Amado
Carla Pais-Vieira
Fátima Sousa
Fátima Cerqueira
Eugénia Pinto
Miguel Pais-Vieira
Quality of life and therapeutic regimen management in onychomycosis patients and in vitro study of antiseptic solutions
description Abstract Onychomycosis or tinea unguium (EE12.1) and Onychomycosis due to non-dermatophyte moulds (1F2D.5) (OM) is a fungal infection of the nail plates with a high prevalence that often affects vulnerable people with co-existing health problems. Gold standard pharmacological treatments for onychomycosis have been associated with low success rates and increasing antifungal resistance, suggesting that treatment outcome is dependent on multiple variables. Here, the prevalence of OM and quality of life were characterized in two vulnerable populations—Hospital patients and Homeless people. Comparing both groups, the most prevalent fungal species were identified in Hospital patients. Then, the in vitro fungicidal properties of the antiseptics povidone-iodine, polyhexamethylene biguanide-betaine, octenidine dihydrochloride, and a super-oxidized solution against two ATCC strains (Candida albicans and Aspergillus niger) and three clinical fungal isolates from Hospital patients (Candida parapsilosis, Trichophyton interdigitale, and Trichophyton rubrum) were tested. OM prevalence was high in both patient groups studied, who also reported a reduction in quality of life and concerns about the state of their feet. In addition, Hospital patients had a non-negligent therapeutic regimen management style. Antiseptics tested in vitro revealed antifungal properties. As antiseptics are low-cost and easy to apply and have few iatrogenic effects, the demonstration of fungicidal properties of these solutions suggests that they may constitute potential supportive therapeutics for OM.
format article
author Vasco Silva-Neves
Vitor Hugo
Paulo Alves
João Costa Amado
Carla Pais-Vieira
Fátima Sousa
Fátima Cerqueira
Eugénia Pinto
Miguel Pais-Vieira
author_facet Vasco Silva-Neves
Vitor Hugo
Paulo Alves
João Costa Amado
Carla Pais-Vieira
Fátima Sousa
Fátima Cerqueira
Eugénia Pinto
Miguel Pais-Vieira
author_sort Vasco Silva-Neves
title Quality of life and therapeutic regimen management in onychomycosis patients and in vitro study of antiseptic solutions
title_short Quality of life and therapeutic regimen management in onychomycosis patients and in vitro study of antiseptic solutions
title_full Quality of life and therapeutic regimen management in onychomycosis patients and in vitro study of antiseptic solutions
title_fullStr Quality of life and therapeutic regimen management in onychomycosis patients and in vitro study of antiseptic solutions
title_full_unstemmed Quality of life and therapeutic regimen management in onychomycosis patients and in vitro study of antiseptic solutions
title_sort quality of life and therapeutic regimen management in onychomycosis patients and in vitro study of antiseptic solutions
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/7d21d3faad0141b6b72a94b4ee6d74c1
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