The Contribution of the Hunger Hormone Leptin in the Aetiology of Postoperative Anorexia after Laparoscopic and Open Gastrectomy in Gastric Cancer Patients

Background: Laparoscopic surgery produces lesser postoperative inflammation with a smaller cytokine and leptin response, and might thus reduce postoperative anorexia compared with open surgery. The aim of the present study was to determine the role of serum leptin in postoperative anorexia after lap...

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Autor principal:	Tomaz Jagric
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	serum leptin nutritional status laparoscopic gastrectomy Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/7d247d0dbc544893acfa93cc55223641
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spelling	oai:doaj.org-article:7d247d0dbc544893acfa93cc552236412021-11-25T16:52:41ZThe Contribution of the Hunger Hormone Leptin in the Aetiology of Postoperative Anorexia after Laparoscopic and Open Gastrectomy in Gastric Cancer Patients10.3390/biom111116012218-273Xhttps://doaj.org/article/7d247d0dbc544893acfa93cc552236412021-10-01T00:00:00Zhttps://www.mdpi.com/2218-273X/11/11/1601https://doaj.org/toc/2218-273XBackground: Laparoscopic surgery produces lesser postoperative inflammation with a smaller cytokine and leptin response, and might thus reduce postoperative anorexia compared with open surgery. The aim of the present study was to determine the role of serum leptin in postoperative anorexia after laparoscopic gastric cancer surgery. Methods: Fifty-four consecutive patients with adenocarcinoma of the stomach were operated on either with open or laparoscopic surgery. Correlations were determined between the serum levels of leptin, clinico-pathological characteristics, serum haemoglobin, and albumin. Results: Serum leptin levels on day seven were correlated significantly to gender (<i>p</i> = 0.004), body mass index (BMI) (<i>p</i> = 0.002), and tumour grade (<i>p</i> = 0.033). In the patients with C-reactive protein (CRP) < 100 mg/L (<i>n</i> = 46) the leptin levels on day seven were significantly lower after the laparoscopic operation (<i>p</i> = 0.042) and in patients with lower BMI (<i>p</i> = 0.001). The linear regression model determined a significant correlation between the relative concentration of leptin on day seven and laparoscopic surgery (Beta−0.688; <i>p</i> < 0.0001), gender, BMI, location of the tumour, T stage, N stage, perioperative therapy, tumour grade, perineural invasion, Lauren histological type, and ulceration. In patients with CRP levels below 100 mg/mL, the serum level of albumin on day seven after surgery was significantly higher in patients after laparoscopic surgery. Conclusion: Laparoscopic surgery produced significantly lower relative leptin concentrations on day seven, and higher serum albumin levels in the subgroup with CRP levels below 100 mg/L at discharge. These results suggested that laparoscopic gastric cancer surgery might reduce postoperative leptin response, leading to a better nutritional status at discharge compared with open surgery.Tomaz JagricMDPI AGarticleserum leptinnutritional statuslaparoscopic gastrectomyMicrobiologyQR1-502ENBiomolecules, Vol 11, Iss 1601, p 1601 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	serum leptin nutritional status laparoscopic gastrectomy Microbiology QR1-502
spellingShingle	serum leptin nutritional status laparoscopic gastrectomy Microbiology QR1-502 Tomaz Jagric The Contribution of the Hunger Hormone Leptin in the Aetiology of Postoperative Anorexia after Laparoscopic and Open Gastrectomy in Gastric Cancer Patients
description	Background: Laparoscopic surgery produces lesser postoperative inflammation with a smaller cytokine and leptin response, and might thus reduce postoperative anorexia compared with open surgery. The aim of the present study was to determine the role of serum leptin in postoperative anorexia after laparoscopic gastric cancer surgery. Methods: Fifty-four consecutive patients with adenocarcinoma of the stomach were operated on either with open or laparoscopic surgery. Correlations were determined between the serum levels of leptin, clinico-pathological characteristics, serum haemoglobin, and albumin. Results: Serum leptin levels on day seven were correlated significantly to gender (<i>p</i> = 0.004), body mass index (BMI) (<i>p</i> = 0.002), and tumour grade (<i>p</i> = 0.033). In the patients with C-reactive protein (CRP) < 100 mg/L (<i>n</i> = 46) the leptin levels on day seven were significantly lower after the laparoscopic operation (<i>p</i> = 0.042) and in patients with lower BMI (<i>p</i> = 0.001). The linear regression model determined a significant correlation between the relative concentration of leptin on day seven and laparoscopic surgery (Beta−0.688; <i>p</i> < 0.0001), gender, BMI, location of the tumour, T stage, N stage, perioperative therapy, tumour grade, perineural invasion, Lauren histological type, and ulceration. In patients with CRP levels below 100 mg/mL, the serum level of albumin on day seven after surgery was significantly higher in patients after laparoscopic surgery. Conclusion: Laparoscopic surgery produced significantly lower relative leptin concentrations on day seven, and higher serum albumin levels in the subgroup with CRP levels below 100 mg/L at discharge. These results suggested that laparoscopic gastric cancer surgery might reduce postoperative leptin response, leading to a better nutritional status at discharge compared with open surgery.
format	article
author	Tomaz Jagric
author_facet	Tomaz Jagric
author_sort	Tomaz Jagric
title	The Contribution of the Hunger Hormone Leptin in the Aetiology of Postoperative Anorexia after Laparoscopic and Open Gastrectomy in Gastric Cancer Patients
title_short	The Contribution of the Hunger Hormone Leptin in the Aetiology of Postoperative Anorexia after Laparoscopic and Open Gastrectomy in Gastric Cancer Patients
title_full	The Contribution of the Hunger Hormone Leptin in the Aetiology of Postoperative Anorexia after Laparoscopic and Open Gastrectomy in Gastric Cancer Patients
title_fullStr	The Contribution of the Hunger Hormone Leptin in the Aetiology of Postoperative Anorexia after Laparoscopic and Open Gastrectomy in Gastric Cancer Patients
title_full_unstemmed	The Contribution of the Hunger Hormone Leptin in the Aetiology of Postoperative Anorexia after Laparoscopic and Open Gastrectomy in Gastric Cancer Patients
title_sort	contribution of the hunger hormone leptin in the aetiology of postoperative anorexia after laparoscopic and open gastrectomy in gastric cancer patients
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/7d247d0dbc544893acfa93cc55223641
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The Contribution of the Hunger Hormone Leptin in the Aetiology of Postoperative Anorexia after Laparoscopic and Open Gastrectomy in Gastric Cancer Patients

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