Microfluidics-based encapsulation of isoniazid in egg white/carrageenan microparticles for sustained release

The prevalence of tuberculosis continuously grows and there is an imperious need to improve the therapeutic efficacy of approved drugs for clinical use. Here we report the encapsulation of isoniazid (INH) in egg white/κ-carrageenan microparticles, which are intended for drug vehiculation through the...

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Autores principales:	Robinson C. Marengo, Luciano N. Mengatto, María L. Olivares, Claudio L.A. Berli
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Isoniazid Encapsulation Microfluidics Egg white/carrageenan Drug release Nutrition. Foods and food supply TX341-641 Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/7d26e44d0f4b410bbf1c59a546017d1f
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spelling	oai:doaj.org-article:7d26e44d0f4b410bbf1c59a546017d1f2021-11-28T04:39:44ZMicrofluidics-based encapsulation of isoniazid in egg white/carrageenan microparticles for sustained release2667-025910.1016/j.fhfh.2021.100041https://doaj.org/article/7d26e44d0f4b410bbf1c59a546017d1f2021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2667025921000339https://doaj.org/toc/2667-0259The prevalence of tuberculosis continuously grows and there is an imperious need to improve the therapeutic efficacy of approved drugs for clinical use. Here we report the encapsulation of isoniazid (INH) in egg white/κ-carrageenan microparticles, which are intended for drug vehiculation through the gastrointestinal tract and controlled release in the ileum. Spherical and highly monodisperse microparticles (255 mm average diameter) were obtained by droplet-based microfluidics and subsequent microwave irradiation. The entire amount of INH added to the particles was encapsulated. Infrared spectra revealed the formation of esters, hydrogen bonding, and Maillard reaction in the biopolymer matrix. In vitro release experiments were carried out in media that systematically emulate the stomach and intestinal tract conditions: 37 °C, NaCl 0.05 mol/L, pH 1.6, for the first 2 h, and Tris–HCl 0.1 mol/L, pH 7, for the next 24 h. A small fraction of the loaded INH was released in the first medium and most of the drug was progressively delivered in the second medium. The release profiles of microparticles were analyzed by using classical kinetic models, which enabled to hypothesize the release mechanism of INH from the biopolymer matrix. This knowledge, together with the ability to control the governing parameters of microfluidic elaboration, opens further possibilities for designing optimal prototypes for sustained release.Robinson C. MarengoLuciano N. MengattoMaría L. OlivaresClaudio L.A. BerliElsevierarticleIsoniazidEncapsulationMicrofluidicsEgg white/carrageenanDrug releaseNutrition. Foods and food supplyTX341-641Nutritional diseases. Deficiency diseasesRC620-627ENFood Hydrocolloids for Health, Vol 1, Iss , Pp 100041- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Isoniazid Encapsulation Microfluidics Egg white/carrageenan Drug release Nutrition. Foods and food supply TX341-641 Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	Isoniazid Encapsulation Microfluidics Egg white/carrageenan Drug release Nutrition. Foods and food supply TX341-641 Nutritional diseases. Deficiency diseases RC620-627 Robinson C. Marengo Luciano N. Mengatto María L. Olivares Claudio L.A. Berli Microfluidics-based encapsulation of isoniazid in egg white/carrageenan microparticles for sustained release
description	The prevalence of tuberculosis continuously grows and there is an imperious need to improve the therapeutic efficacy of approved drugs for clinical use. Here we report the encapsulation of isoniazid (INH) in egg white/κ-carrageenan microparticles, which are intended for drug vehiculation through the gastrointestinal tract and controlled release in the ileum. Spherical and highly monodisperse microparticles (255 mm average diameter) were obtained by droplet-based microfluidics and subsequent microwave irradiation. The entire amount of INH added to the particles was encapsulated. Infrared spectra revealed the formation of esters, hydrogen bonding, and Maillard reaction in the biopolymer matrix. In vitro release experiments were carried out in media that systematically emulate the stomach and intestinal tract conditions: 37 °C, NaCl 0.05 mol/L, pH 1.6, for the first 2 h, and Tris–HCl 0.1 mol/L, pH 7, for the next 24 h. A small fraction of the loaded INH was released in the first medium and most of the drug was progressively delivered in the second medium. The release profiles of microparticles were analyzed by using classical kinetic models, which enabled to hypothesize the release mechanism of INH from the biopolymer matrix. This knowledge, together with the ability to control the governing parameters of microfluidic elaboration, opens further possibilities for designing optimal prototypes for sustained release.
format	article
author	Robinson C. Marengo Luciano N. Mengatto María L. Olivares Claudio L.A. Berli
author_facet	Robinson C. Marengo Luciano N. Mengatto María L. Olivares Claudio L.A. Berli
author_sort	Robinson C. Marengo
title	Microfluidics-based encapsulation of isoniazid in egg white/carrageenan microparticles for sustained release
title_short	Microfluidics-based encapsulation of isoniazid in egg white/carrageenan microparticles for sustained release
title_full	Microfluidics-based encapsulation of isoniazid in egg white/carrageenan microparticles for sustained release
title_fullStr	Microfluidics-based encapsulation of isoniazid in egg white/carrageenan microparticles for sustained release
title_full_unstemmed	Microfluidics-based encapsulation of isoniazid in egg white/carrageenan microparticles for sustained release
title_sort	microfluidics-based encapsulation of isoniazid in egg white/carrageenan microparticles for sustained release
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/7d26e44d0f4b410bbf1c59a546017d1f
work_keys_str_mv	AT robinsoncmarengo microfluidicsbasedencapsulationofisoniazidineggwhitecarrageenanmicroparticlesforsustainedrelease AT lucianonmengatto microfluidicsbasedencapsulationofisoniazidineggwhitecarrageenanmicroparticlesforsustainedrelease AT marialolivares microfluidicsbasedencapsulationofisoniazidineggwhitecarrageenanmicroparticlesforsustainedrelease AT claudiolaberli microfluidicsbasedencapsulationofisoniazidineggwhitecarrageenanmicroparticlesforsustainedrelease
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Microfluidics-based encapsulation of isoniazid in egg white/carrageenan microparticles for sustained release

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