Differential effects of acute cerebellectomy on cough in spontaneously breathing cats.

The role of the cerebellum in controlling the cough motor pattern is not well understood. We hypothesized that cerebellectomy would disinhibit motor drive to respiratory muscles during cough. Cough was induced by mechanical stimulation of the tracheobronchial airways in anesthetized, spontaneously b...

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Autores principales:	M Nicholas Musselwhite, Tabitha Y Shen, Melanie J Rose, Kimberly E Iceman, Ivan Poliacek, Teresa Pitts, Donald C Bolser
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7d283257e6eb498789bad545da8d1e2f
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spelling	oai:doaj.org-article:7d283257e6eb498789bad545da8d1e2f2021-12-02T20:15:48ZDifferential effects of acute cerebellectomy on cough in spontaneously breathing cats.1932-620310.1371/journal.pone.0253060https://doaj.org/article/7d283257e6eb498789bad545da8d1e2f2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0253060https://doaj.org/toc/1932-6203The role of the cerebellum in controlling the cough motor pattern is not well understood. We hypothesized that cerebellectomy would disinhibit motor drive to respiratory muscles during cough. Cough was induced by mechanical stimulation of the tracheobronchial airways in anesthetized, spontaneously breathing adult cats (8 male, 1 female), and electromyograms (EMGs) were recorded from upper airway, chest wall, and abdominal respiratory muscles. Cough trials were performed before and at two time points after total cerebellectomy (10 minutes and >1 hour). Unlike a prior report in paralyzed, decerebrated, and artificially ventilated animals, we observed that cerebellectomy had no effect on cough frequency. After cerebellectomy, thoracic inspiratory muscle EMG magnitudes increased during cough (diaphragm EMG increased by 14% at 10 minutes, p = 0.04; parasternal by 34% at 10 minutes and by 32% at >1 hour, p = 0.001 and 0.03 respectively). During cough at 10 minutes after cerebellectomy, inspiratory esophageal pressure was increased by 44% (p = 0.004), thyroarytenoid (laryngeal adductor) muscle EMG amplitude increased 13% (p = 0.04), and no change was observed in the posterior cricoarytenoid (laryngeal abductor) EMG. Cough phase durations did not change. Blood pressure and heart rate were reduced after cerebellectomy, and respiratory rate also decreased due to an increase in duration of the expiratory phase of breathing. Changes in cough-related EMG magnitudes of respiratory muscles suggest that the cerebellum exerts inhibitory control of cough motor drive, but not cough number or phase timing in response to mechanical stimuli in this model early after cerebellectomy. However, results varied widely at >1 hour after cerebellectomy, with some animals exhibiting enhancement or suppression of one or more components of the cough motor behavior. These results suggest that, while the cerebellum and behavior-related sensory feedback regulate cough, it may be difficult to predict the nature of the modulation based on total cerebellectomy.M Nicholas MusselwhiteTabitha Y ShenMelanie J RoseKimberly E IcemanIvan PoliacekTeresa PittsDonald C BolserPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0253060 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q M Nicholas Musselwhite Tabitha Y Shen Melanie J Rose Kimberly E Iceman Ivan Poliacek Teresa Pitts Donald C Bolser Differential effects of acute cerebellectomy on cough in spontaneously breathing cats.
description	The role of the cerebellum in controlling the cough motor pattern is not well understood. We hypothesized that cerebellectomy would disinhibit motor drive to respiratory muscles during cough. Cough was induced by mechanical stimulation of the tracheobronchial airways in anesthetized, spontaneously breathing adult cats (8 male, 1 female), and electromyograms (EMGs) were recorded from upper airway, chest wall, and abdominal respiratory muscles. Cough trials were performed before and at two time points after total cerebellectomy (10 minutes and >1 hour). Unlike a prior report in paralyzed, decerebrated, and artificially ventilated animals, we observed that cerebellectomy had no effect on cough frequency. After cerebellectomy, thoracic inspiratory muscle EMG magnitudes increased during cough (diaphragm EMG increased by 14% at 10 minutes, p = 0.04; parasternal by 34% at 10 minutes and by 32% at >1 hour, p = 0.001 and 0.03 respectively). During cough at 10 minutes after cerebellectomy, inspiratory esophageal pressure was increased by 44% (p = 0.004), thyroarytenoid (laryngeal adductor) muscle EMG amplitude increased 13% (p = 0.04), and no change was observed in the posterior cricoarytenoid (laryngeal abductor) EMG. Cough phase durations did not change. Blood pressure and heart rate were reduced after cerebellectomy, and respiratory rate also decreased due to an increase in duration of the expiratory phase of breathing. Changes in cough-related EMG magnitudes of respiratory muscles suggest that the cerebellum exerts inhibitory control of cough motor drive, but not cough number or phase timing in response to mechanical stimuli in this model early after cerebellectomy. However, results varied widely at >1 hour after cerebellectomy, with some animals exhibiting enhancement or suppression of one or more components of the cough motor behavior. These results suggest that, while the cerebellum and behavior-related sensory feedback regulate cough, it may be difficult to predict the nature of the modulation based on total cerebellectomy.
format	article
author	M Nicholas Musselwhite Tabitha Y Shen Melanie J Rose Kimberly E Iceman Ivan Poliacek Teresa Pitts Donald C Bolser
author_facet	M Nicholas Musselwhite Tabitha Y Shen Melanie J Rose Kimberly E Iceman Ivan Poliacek Teresa Pitts Donald C Bolser
author_sort	M Nicholas Musselwhite
title	Differential effects of acute cerebellectomy on cough in spontaneously breathing cats.
title_short	Differential effects of acute cerebellectomy on cough in spontaneously breathing cats.
title_full	Differential effects of acute cerebellectomy on cough in spontaneously breathing cats.
title_fullStr	Differential effects of acute cerebellectomy on cough in spontaneously breathing cats.
title_full_unstemmed	Differential effects of acute cerebellectomy on cough in spontaneously breathing cats.
title_sort	differential effects of acute cerebellectomy on cough in spontaneously breathing cats.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/7d283257e6eb498789bad545da8d1e2f
work_keys_str_mv	AT mnicholasmusselwhite differentialeffectsofacutecerebellectomyoncoughinspontaneouslybreathingcats AT tabithayshen differentialeffectsofacutecerebellectomyoncoughinspontaneouslybreathingcats AT melaniejrose differentialeffectsofacutecerebellectomyoncoughinspontaneouslybreathingcats AT kimberlyeiceman differentialeffectsofacutecerebellectomyoncoughinspontaneouslybreathingcats AT ivanpoliacek differentialeffectsofacutecerebellectomyoncoughinspontaneouslybreathingcats AT teresapitts differentialeffectsofacutecerebellectomyoncoughinspontaneouslybreathingcats AT donaldcbolser differentialeffectsofacutecerebellectomyoncoughinspontaneouslybreathingcats
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Differential effects of acute cerebellectomy on cough in spontaneously breathing cats.

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