Reprogramming mouse fibroblasts into engraftable myeloerythroid and lymphoid progenitors

Reprogramming mouse fibroblasts into engraftable myeloerythroid and lymphoid progenitors

Direct reprogramming of closely-related lineages can generate hematopoietic stem cells. Here, the authors show hematopoietic transcription factors Scl, Lmo2, Runx1 and Bmi1 can reprogram fibroblasts into induced hematopoietic progenitors (iHPs), which are engraftable blood progenitors.

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Detalles Bibliográficos
Autores principales: Hui Cheng, Heather Yin-Kuan Ang, Chadi A. EL Farran, Pin Li, Hai Tong Fang, Tong Ming Liu, Say Li Kong, Michael Lingzi Chin, Wei Yin Ling, Edwin Kok Hao Lim, Hu Li, Tara Huber, Kyle M. Loh, Yuin-Han Loh, Bing Lim
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Science
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Acceso en línea:https://doaj.org/article/7d2ce78d316b47009ea53ac3b86aacc1
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Descripción
Sumario:Direct reprogramming of closely-related lineages can generate hematopoietic stem cells. Here, the authors show hematopoietic transcription factors Scl, Lmo2, Runx1 and Bmi1 can reprogram fibroblasts into induced hematopoietic progenitors (iHPs), which are engraftable blood progenitors.

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