Reprogramming mouse fibroblasts into engraftable myeloerythroid and lymphoid progenitors

Direct reprogramming of closely-related lineages can generate hematopoietic stem cells. Here, the authors show hematopoietic transcription factors Scl, Lmo2, Runx1 and Bmi1 can reprogram fibroblasts into induced hematopoietic progenitors (iHPs), which are engraftable blood progenitors.

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Autores principales:	Hui Cheng, Heather Yin-Kuan Ang, Chadi A. EL Farran, Pin Li, Hai Tong Fang, Tong Ming Liu, Say Li Kong, Michael Lingzi Chin, Wei Yin Ling, Edwin Kok Hao Lim, Hu Li, Tara Huber, Kyle M. Loh, Yuin-Han Loh, Bing Lim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7d2ce78d316b47009ea53ac3b86aacc1
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spelling	oai:doaj.org-article:7d2ce78d316b47009ea53ac3b86aacc12021-12-02T15:35:23ZReprogramming mouse fibroblasts into engraftable myeloerythroid and lymphoid progenitors10.1038/ncomms133962041-1723https://doaj.org/article/7d2ce78d316b47009ea53ac3b86aacc12016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13396https://doaj.org/toc/2041-1723Direct reprogramming of closely-related lineages can generate hematopoietic stem cells. Here, the authors show hematopoietic transcription factors Scl, Lmo2, Runx1 and Bmi1 can reprogram fibroblasts into induced hematopoietic progenitors (iHPs), which are engraftable blood progenitors.Hui ChengHeather Yin-Kuan AngChadi A. EL FarranPin LiHai Tong FangTong Ming LiuSay Li KongMichael Lingzi ChinWei Yin LingEdwin Kok Hao LimHu LiTara HuberKyle M. LohYuin-Han LohBing LimNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hui Cheng Heather Yin-Kuan Ang Chadi A. EL Farran Pin Li Hai Tong Fang Tong Ming Liu Say Li Kong Michael Lingzi Chin Wei Yin Ling Edwin Kok Hao Lim Hu Li Tara Huber Kyle M. Loh Yuin-Han Loh Bing Lim Reprogramming mouse fibroblasts into engraftable myeloerythroid and lymphoid progenitors
description	Direct reprogramming of closely-related lineages can generate hematopoietic stem cells. Here, the authors show hematopoietic transcription factors Scl, Lmo2, Runx1 and Bmi1 can reprogram fibroblasts into induced hematopoietic progenitors (iHPs), which are engraftable blood progenitors.
format	article
author	Hui Cheng Heather Yin-Kuan Ang Chadi A. EL Farran Pin Li Hai Tong Fang Tong Ming Liu Say Li Kong Michael Lingzi Chin Wei Yin Ling Edwin Kok Hao Lim Hu Li Tara Huber Kyle M. Loh Yuin-Han Loh Bing Lim
author_facet	Hui Cheng Heather Yin-Kuan Ang Chadi A. EL Farran Pin Li Hai Tong Fang Tong Ming Liu Say Li Kong Michael Lingzi Chin Wei Yin Ling Edwin Kok Hao Lim Hu Li Tara Huber Kyle M. Loh Yuin-Han Loh Bing Lim
author_sort	Hui Cheng
title	Reprogramming mouse fibroblasts into engraftable myeloerythroid and lymphoid progenitors
title_short	Reprogramming mouse fibroblasts into engraftable myeloerythroid and lymphoid progenitors
title_full	Reprogramming mouse fibroblasts into engraftable myeloerythroid and lymphoid progenitors
title_fullStr	Reprogramming mouse fibroblasts into engraftable myeloerythroid and lymphoid progenitors
title_full_unstemmed	Reprogramming mouse fibroblasts into engraftable myeloerythroid and lymphoid progenitors
title_sort	reprogramming mouse fibroblasts into engraftable myeloerythroid and lymphoid progenitors
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/7d2ce78d316b47009ea53ac3b86aacc1
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Reprogramming mouse fibroblasts into engraftable myeloerythroid and lymphoid progenitors

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