Weeklong improved colour contrasts sensitivity after single 670 nm exposures associated with enhanced mitochondrial function

Abstract Mitochondrial decline in ageing robs cells of ATP. However, animal studies show that long wavelength exposure (650–900 nm) over weeks partially restores ATP and improves function. The likely mechanism is via long wavelengths reducing nanoscopic interfacial water viscosity around ATP rota pu...

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Autores principales:	Harpreet Shinhmar, Chris Hogg, Magella Neveu, Glen Jeffery
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7d30c0af774e4c9e8eb7f47425565d9e
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spelling	oai:doaj.org-article:7d30c0af774e4c9e8eb7f47425565d9e2021-11-28T12:16:58ZWeeklong improved colour contrasts sensitivity after single 670 nm exposures associated with enhanced mitochondrial function10.1038/s41598-021-02311-12045-2322https://doaj.org/article/7d30c0af774e4c9e8eb7f47425565d9e2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02311-1https://doaj.org/toc/2045-2322Abstract Mitochondrial decline in ageing robs cells of ATP. However, animal studies show that long wavelength exposure (650–900 nm) over weeks partially restores ATP and improves function. The likely mechanism is via long wavelengths reducing nanoscopic interfacial water viscosity around ATP rota pumps, improving their efficiency. Recently, repeated 670 nm exposures have been used on the aged human retina, which has high-energy demands and significant mitochondrial and functional decline, to improve vision. We show here that single 3 min 670 nm exposures, at much lower energies than previously used, are sufficient to significantly improve for 1 week cone mediated colour contrast thresholds (detection) in ageing populations (37–70 years) to levels associated with younger subjects. But light needs to be delivered at specific times. In environments with artificial lighting humans are rarely dark-adapted, hence cone function becomes critical. This intervention, demonstrated to improve aged mitochondrial function can be applied to enhance colour vision in old age.Harpreet ShinhmarChris HoggMagella NeveuGlen JefferyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Harpreet Shinhmar Chris Hogg Magella Neveu Glen Jeffery Weeklong improved colour contrasts sensitivity after single 670 nm exposures associated with enhanced mitochondrial function
description	Abstract Mitochondrial decline in ageing robs cells of ATP. However, animal studies show that long wavelength exposure (650–900 nm) over weeks partially restores ATP and improves function. The likely mechanism is via long wavelengths reducing nanoscopic interfacial water viscosity around ATP rota pumps, improving their efficiency. Recently, repeated 670 nm exposures have been used on the aged human retina, which has high-energy demands and significant mitochondrial and functional decline, to improve vision. We show here that single 3 min 670 nm exposures, at much lower energies than previously used, are sufficient to significantly improve for 1 week cone mediated colour contrast thresholds (detection) in ageing populations (37–70 years) to levels associated with younger subjects. But light needs to be delivered at specific times. In environments with artificial lighting humans are rarely dark-adapted, hence cone function becomes critical. This intervention, demonstrated to improve aged mitochondrial function can be applied to enhance colour vision in old age.
format	article
author	Harpreet Shinhmar Chris Hogg Magella Neveu Glen Jeffery
author_facet	Harpreet Shinhmar Chris Hogg Magella Neveu Glen Jeffery
author_sort	Harpreet Shinhmar
title	Weeklong improved colour contrasts sensitivity after single 670 nm exposures associated with enhanced mitochondrial function
title_short	Weeklong improved colour contrasts sensitivity after single 670 nm exposures associated with enhanced mitochondrial function
title_full	Weeklong improved colour contrasts sensitivity after single 670 nm exposures associated with enhanced mitochondrial function
title_fullStr	Weeklong improved colour contrasts sensitivity after single 670 nm exposures associated with enhanced mitochondrial function
title_full_unstemmed	Weeklong improved colour contrasts sensitivity after single 670 nm exposures associated with enhanced mitochondrial function
title_sort	weeklong improved colour contrasts sensitivity after single 670 nm exposures associated with enhanced mitochondrial function
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7d30c0af774e4c9e8eb7f47425565d9e
work_keys_str_mv	AT harpreetshinhmar weeklongimprovedcolourcontrastssensitivityaftersingle670nmexposuresassociatedwithenhancedmitochondrialfunction AT chrishogg weeklongimprovedcolourcontrastssensitivityaftersingle670nmexposuresassociatedwithenhancedmitochondrialfunction AT magellaneveu weeklongimprovedcolourcontrastssensitivityaftersingle670nmexposuresassociatedwithenhancedmitochondrialfunction AT glenjeffery weeklongimprovedcolourcontrastssensitivityaftersingle670nmexposuresassociatedwithenhancedmitochondrialfunction
_version_	1718408085600468992

Weeklong improved colour contrasts sensitivity after single 670 nm exposures associated with enhanced mitochondrial function

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