Clinicopathological factors associated with synchronous distant metastasis and prognosis of stage T1 colorectal cancer patients

Abstract It is rare and understudied for patients with stage T1 colorectal cancer to have synchronous distant metastasis. This study was to determine the clinicopathological factors associated with distant metastasis and prognosis. T1 colorectal cancer patients diagnosed between 2010 and 2015 were o...

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Autores principales:	Qiken Li, Gang Wang, Jun Luo, Bo Li, Weiping Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7d32179ad09c4b7281e4b28b48f54ac1
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spelling	oai:doaj.org-article:7d32179ad09c4b7281e4b28b48f54ac12021-12-02T17:32:56ZClinicopathological factors associated with synchronous distant metastasis and prognosis of stage T1 colorectal cancer patients10.1038/s41598-021-87929-x2045-2322https://doaj.org/article/7d32179ad09c4b7281e4b28b48f54ac12021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87929-xhttps://doaj.org/toc/2045-2322Abstract It is rare and understudied for patients with stage T1 colorectal cancer to have synchronous distant metastasis. This study was to determine the clinicopathological factors associated with distant metastasis and prognosis. T1 colorectal cancer patients diagnosed between 2010 and 2015 were obtained from the SEER database. Logistic regression was applied to determine risk factors related to distant metastasis. Cox-proportional hazard models were used to identify the prognostic factors for patients with distant metastasis. Among 21,321 patients identified, 359 (1.8%) had synchronous distant metastasis and 1807 (8.5%) had lymph node metastasis. Multivariate analysis revealed that younger age, positive serum CEA, larger tumor size, positive tumor deposit, perineural invasion, lymph node metastasis, histology of non-adenocarcinoma and poorer differentiation were significantly associated with the increased risk of synchronous distant metastasis. Older age, female, Black, positive CEA, positive lymph node metastasis, positive tumor deposit, larger tumor size, no chemotherapy, inadequate lymph node harvesting and no metastasectomy were correlated with worse survival in these patients with synchronous distant metastasis. Patients with metastasis to the liver displayed the highest rate of positive CEA. We conclude that T1 colorectal cancer patients with multiple risk factors need thorough examinations to exclude synchronous distant metastasis. Chemotherapy, adequate lymph node cleaning and metastasectomy are associated with improved survival for those patients with distant metastases. Positive serum CEA may be useful in predicting distant metastases in patients at stage T1.Qiken LiGang WangJun LuoBo LiWeiping ChenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Qiken Li Gang Wang Jun Luo Bo Li Weiping Chen Clinicopathological factors associated with synchronous distant metastasis and prognosis of stage T1 colorectal cancer patients
description	Abstract It is rare and understudied for patients with stage T1 colorectal cancer to have synchronous distant metastasis. This study was to determine the clinicopathological factors associated with distant metastasis and prognosis. T1 colorectal cancer patients diagnosed between 2010 and 2015 were obtained from the SEER database. Logistic regression was applied to determine risk factors related to distant metastasis. Cox-proportional hazard models were used to identify the prognostic factors for patients with distant metastasis. Among 21,321 patients identified, 359 (1.8%) had synchronous distant metastasis and 1807 (8.5%) had lymph node metastasis. Multivariate analysis revealed that younger age, positive serum CEA, larger tumor size, positive tumor deposit, perineural invasion, lymph node metastasis, histology of non-adenocarcinoma and poorer differentiation were significantly associated with the increased risk of synchronous distant metastasis. Older age, female, Black, positive CEA, positive lymph node metastasis, positive tumor deposit, larger tumor size, no chemotherapy, inadequate lymph node harvesting and no metastasectomy were correlated with worse survival in these patients with synchronous distant metastasis. Patients with metastasis to the liver displayed the highest rate of positive CEA. We conclude that T1 colorectal cancer patients with multiple risk factors need thorough examinations to exclude synchronous distant metastasis. Chemotherapy, adequate lymph node cleaning and metastasectomy are associated with improved survival for those patients with distant metastases. Positive serum CEA may be useful in predicting distant metastases in patients at stage T1.
format	article
author	Qiken Li Gang Wang Jun Luo Bo Li Weiping Chen
author_facet	Qiken Li Gang Wang Jun Luo Bo Li Weiping Chen
author_sort	Qiken Li
title	Clinicopathological factors associated with synchronous distant metastasis and prognosis of stage T1 colorectal cancer patients
title_short	Clinicopathological factors associated with synchronous distant metastasis and prognosis of stage T1 colorectal cancer patients
title_full	Clinicopathological factors associated with synchronous distant metastasis and prognosis of stage T1 colorectal cancer patients
title_fullStr	Clinicopathological factors associated with synchronous distant metastasis and prognosis of stage T1 colorectal cancer patients
title_full_unstemmed	Clinicopathological factors associated with synchronous distant metastasis and prognosis of stage T1 colorectal cancer patients
title_sort	clinicopathological factors associated with synchronous distant metastasis and prognosis of stage t1 colorectal cancer patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7d32179ad09c4b7281e4b28b48f54ac1
work_keys_str_mv	AT qikenli clinicopathologicalfactorsassociatedwithsynchronousdistantmetastasisandprognosisofstaget1colorectalcancerpatients AT gangwang clinicopathologicalfactorsassociatedwithsynchronousdistantmetastasisandprognosisofstaget1colorectalcancerpatients AT junluo clinicopathologicalfactorsassociatedwithsynchronousdistantmetastasisandprognosisofstaget1colorectalcancerpatients AT boli clinicopathologicalfactorsassociatedwithsynchronousdistantmetastasisandprognosisofstaget1colorectalcancerpatients AT weipingchen clinicopathologicalfactorsassociatedwithsynchronousdistantmetastasisandprognosisofstaget1colorectalcancerpatients
_version_	1718380130678603776

Clinicopathological factors associated with synchronous distant metastasis and prognosis of stage T1 colorectal cancer patients

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