Radiofrequency catheter ablation for ventricular tachycardia in tetralogy of fallot: A systematic review

Background: Ventricular arrhythmias in adult patients following surgical repair of tetralogy of Fallot (TOF) may be challenging to manage and life-threatening. Ventricular tachycardia (VT) is the leading cause of sudden cardiac death in this patient population. Radiofrequency catheter ablation (RFCA...

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Autores principales:	Alexandros P. Evangeliou, Ioannis A. Ziogas, Despoina Ntiloudi, Konstantinos S. Mylonas, Dimitrios V. Avgerinos, Haralambos Karvounis, George Giannakoulas
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Tetralogy of fallot Radiofrequency catheter ablation Ventricular arrhythmia Ventricular tachycardia Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/7d32fb3c236a48bb9b735d5c320f57e8
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spelling	oai:doaj.org-article:7d32fb3c236a48bb9b735d5c320f57e82021-11-10T04:42:10ZRadiofrequency catheter ablation for ventricular tachycardia in tetralogy of fallot: A systematic review2666-668510.1016/j.ijcchd.2021.100265https://doaj.org/article/7d32fb3c236a48bb9b735d5c320f57e82021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2666668521001890https://doaj.org/toc/2666-6685Background: Ventricular arrhythmias in adult patients following surgical repair of tetralogy of Fallot (TOF) may be challenging to manage and life-threatening. Ventricular tachycardia (VT) is the leading cause of sudden cardiac death in this patient population. Radiofrequency catheter ablation (RFCA) constitutes an important treatment modality for VT. Aim: The present study summarizes the outcomes of repaired TOF patients undergoing RFCA for resistant VT. Methods: A systematic literature search of the PubMed and Cochrane databases was performed with respect to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Results: Eight studies including 106 patients were analyzed. Mean patient age at the time of RFCA was 39.0 ± 15.9 years, male:female ratio was 1.97:1. Programmed ventricular stimulation induced sustained VT in 81.6% (95%CI: 72.7–88.1) of patients. VT recurred shortly after the procedure in 16% (95%CI: 10.2–24.3) and during follow-up in 12.2% (95%CI: 6.3–21.7). The post-procedural use of amiodarone and beta-blockers therapy was decreased from 40% (95%CI: 30.3–51.1) to 20% (95%CI: 8.4–39.6) and from 58% (95%CI: 44.2–70.6) to 28% (95%CI: 14.1–47.8) of patients, respectively. A repeat RFCA procedure was required in 17.5% (95%CI: 11.1–26.4). No in-hospital deaths occurred, while overall mortality rate during a mean follow-up of 73.5 ± 61.4 months was 3% (95%CI: 0.2–10.9). Conclusion: RFCA can control ventricular dysrhythmias in over 80% of the cases, with zero in-hospital and low overall mortality, while substantially reducing the need for antiarrhythmic drugs.Alexandros P. EvangeliouIoannis A. ZiogasDespoina NtiloudiKonstantinos S. MylonasDimitrios V. AvgerinosHaralambos KarvounisGeorge GiannakoulasElsevierarticleTetralogy of fallotRadiofrequency catheter ablationVentricular arrhythmiaVentricular tachycardiaDiseases of the circulatory (Cardiovascular) systemRC666-701ENInternational Journal of Cardiology Congenital Heart Disease, Vol 6, Iss , Pp 100265- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Tetralogy of fallot Radiofrequency catheter ablation Ventricular arrhythmia Ventricular tachycardia Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Tetralogy of fallot Radiofrequency catheter ablation Ventricular arrhythmia Ventricular tachycardia Diseases of the circulatory (Cardiovascular) system RC666-701 Alexandros P. Evangeliou Ioannis A. Ziogas Despoina Ntiloudi Konstantinos S. Mylonas Dimitrios V. Avgerinos Haralambos Karvounis George Giannakoulas Radiofrequency catheter ablation for ventricular tachycardia in tetralogy of fallot: A systematic review
description	Background: Ventricular arrhythmias in adult patients following surgical repair of tetralogy of Fallot (TOF) may be challenging to manage and life-threatening. Ventricular tachycardia (VT) is the leading cause of sudden cardiac death in this patient population. Radiofrequency catheter ablation (RFCA) constitutes an important treatment modality for VT. Aim: The present study summarizes the outcomes of repaired TOF patients undergoing RFCA for resistant VT. Methods: A systematic literature search of the PubMed and Cochrane databases was performed with respect to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Results: Eight studies including 106 patients were analyzed. Mean patient age at the time of RFCA was 39.0 ± 15.9 years, male:female ratio was 1.97:1. Programmed ventricular stimulation induced sustained VT in 81.6% (95%CI: 72.7–88.1) of patients. VT recurred shortly after the procedure in 16% (95%CI: 10.2–24.3) and during follow-up in 12.2% (95%CI: 6.3–21.7). The post-procedural use of amiodarone and beta-blockers therapy was decreased from 40% (95%CI: 30.3–51.1) to 20% (95%CI: 8.4–39.6) and from 58% (95%CI: 44.2–70.6) to 28% (95%CI: 14.1–47.8) of patients, respectively. A repeat RFCA procedure was required in 17.5% (95%CI: 11.1–26.4). No in-hospital deaths occurred, while overall mortality rate during a mean follow-up of 73.5 ± 61.4 months was 3% (95%CI: 0.2–10.9). Conclusion: RFCA can control ventricular dysrhythmias in over 80% of the cases, with zero in-hospital and low overall mortality, while substantially reducing the need for antiarrhythmic drugs.
format	article
author	Alexandros P. Evangeliou Ioannis A. Ziogas Despoina Ntiloudi Konstantinos S. Mylonas Dimitrios V. Avgerinos Haralambos Karvounis George Giannakoulas
author_facet	Alexandros P. Evangeliou Ioannis A. Ziogas Despoina Ntiloudi Konstantinos S. Mylonas Dimitrios V. Avgerinos Haralambos Karvounis George Giannakoulas
author_sort	Alexandros P. Evangeliou
title	Radiofrequency catheter ablation for ventricular tachycardia in tetralogy of fallot: A systematic review
title_short	Radiofrequency catheter ablation for ventricular tachycardia in tetralogy of fallot: A systematic review
title_full	Radiofrequency catheter ablation for ventricular tachycardia in tetralogy of fallot: A systematic review
title_fullStr	Radiofrequency catheter ablation for ventricular tachycardia in tetralogy of fallot: A systematic review
title_full_unstemmed	Radiofrequency catheter ablation for ventricular tachycardia in tetralogy of fallot: A systematic review
title_sort	radiofrequency catheter ablation for ventricular tachycardia in tetralogy of fallot: a systematic review
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/7d32fb3c236a48bb9b735d5c320f57e8
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Radiofrequency catheter ablation for ventricular tachycardia in tetralogy of fallot: A systematic review

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