Memory T cells in latent Mycobacterium tuberculosis infection are directed against three antigenic islands and largely contained in a CXCR3+CCR6+ Th1 subset.

Memory T cells in latent Mycobacterium tuberculosis infection are directed against three antigenic islands and largely contained in a CXCR3+CCR6+ Th1 subset.

An understanding of the immunological footprint of Mycobacterium tuberculosis (MTB) CD4 T cell recognition is still incomplete. Here we report that human Th1 cells specific for MTB are largely contained in a CXCR3(+)CCR6(+) memory subset and highly focused on three broadly immunodominant antigenic i...

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Bibliographic Details
Main Authors: Cecilia S Lindestam Arlehamn, Anna Gerasimova, Federico Mele, Ryan Henderson, Justine Swann, Jason A Greenbaum, Yohan Kim, John Sidney, Eddie A James, Randy Taplitz, Denise M McKinney, William W Kwok, Howard Grey, Federica Sallusto, Bjoern Peters, Alessandro Sette
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2013
Subjects:
Immunologic diseases. Allergy
RC581-607
Biology (General)
QH301-705.5
Online Access:https://doaj.org/article/7d339e7bda6e43eab95b487bd676cd5b
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